Papers by Elisabetta Coni
Journal of Pediatric and Neonatal Individualized Medicine (JPNIM), Aug 10, 2016
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Journal of Pediatric and Neonatal Individualized Medicine, Oct 21, 2014
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Necrotizing enterocolitis (NEC) is an acute inflammatory disease of the neonatal intestine that s... more Necrotizing enterocolitis (NEC) is an acute inflammatory disease of the neonatal intestine that strikes in 1 of 1,000 live births. Its etiology is unknown. This review describes in detail the new NECs especially those which affect preterm infants: contagion or lymphocytosis associated, transfusion associated and cow's milk allergy associated. A wide repertory of images are presented, together with algorithms for differential diagnosis.
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Journal of Pediatric and Neonatal Individualized Medicine, Oct 21, 2014
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The Journal of Maternal-Fetal & Neonatal Medicine, 2011
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Early Human Development, Nov 1, 2008
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The Journal of Maternal-Fetal & Neonatal Medicine, 2010
Postpartum depression (PPD) is a non-psychotic depressive disease with varying severity, from mod... more Postpartum depression (PPD) is a non-psychotic depressive disease with varying severity, from moderate to severe, which according to the DSM IV originates after the 4th to 6th week from giving birth [1,2]; according to other experts its onset is within the first 3 months from giving birth [3–6]; others still are of the opinion that the risk may last throughout the first year of the child’s life. The symptomatology may last for some weeks to some months and, if not recognized and treated, may continue indefinitely, with important negative repercussions on the child. Relapses in cases of PPD with the following pregnancy are quite frequent. The most frequent symptoms [2] of postpartum depression are as follows:
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The human adrenal glands arise around the 4 th week of gestation and during the intrauterine life... more The human adrenal glands arise around the 4 th week of gestation and during the intrauterine life produce many substances that are responsible for the maintenance of fetal homeostasis and organ maturation. Stem cell niches represent the microenvironment suitable for life and replication of adrenal stem cells. Adrenal gland stem cells have the capacity to self-renew and generate functional differentiated daughter cells that replenish lost cells. Morphologically the adrenal stem cells appeared as small, polymorphic cells, closed together, with basophilic nucleus, located between adrenal and renal capsules. This study was mainly based on a morphological and immunohistochemical approach, particularly on characterization and localization of the multiple stem/progenitor cells that contribute to the development of the human adrenal gland. Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 201...
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It is possible to distinguish two phases in the development and maturation of the intestine: intr... more It is possible to distinguish two phases in the development and maturation of the intestine: intra-uterine and extra-uterine. Up until the 13 th week of the embryological phase, a fetus’ development is not controlled by factors external to the alimentary canal. It is instead guided by the homeotic genes that control the proliferation and differentiation during the embryogenesis. A fetus’ interaction with the external environment starts with the perforation of the buccal membrane, when the fetus starts swallowing the amniotic fluid. Both in pathological and physiological conditions, the encounter with the microbiota – that surely happens at birth, but could happen before as well – furnishes to the developing intestine elements which are necessary and essential to the growth of the organ, the barrier function, and the specific and nonspecific immunity. The link between development, maturation and inflammation is very important and influences the entire intestinal homeostasis. In case ...
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Metabolomics has provided new insight into the biology that drives the phenotype of stem cells. D... more Metabolomics has provided new insight into the biology that drives the phenotype of stem cells. During the recent years, metabolic circuits of embryonic and neural stem cells (NSCs) have been better elucidated. Many factors contribute to stem cell determination fate: metabolism, transcriptional signaling, epigenetics, extrinsic mechanisms such as short-range signals from the niche and humoral signals. The metabolism decides if a cell proliferates, differentiates or remains quiescent. Embryonic and adult NSCs share two features: they generate at least one daughter cell and can differentiate into specialized cells. NSCs use different pathways depending on their stage of differentiation: glycolysis is highest in proliferating stem cells and it is essential for stemness. Conversely, oxidative phosphorylation supports differentiated cells. Moreover, lipid metabolism maintains proliferation and neurogenesis; indeed, fatty acid oxidation and fatty acid synthesis represent a component of st...
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Journal of Pediatric and Neonatal Individualized Medicine, Oct 21, 2014
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Journal of Pediatric and Neonatal Individualized Medicine, Oct 23, 2012
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International Journal of Clinical Pediatrics, 2015
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Journal of Maternal-Fetal and Neonatal Medicine, 2010
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Journal of Maternal-Fetal and Neonatal Medicine, 2011
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Papers by Elisabetta Coni