Neurocutaneous syndromes (NCSs) are a group of genetic disorders characterized by developmental lesions of the neuroectoderm. We present five cases of NCSs, all of which were associated with seizures presenting in the pediatric age group... more
Neurocutaneous syndromes (NCSs) are a group of genetic disorders characterized by developmental lesions of the neuroectoderm. We present five cases of NCSs, all of which were associated with seizures presenting in the pediatric age group with classical skin lesions.
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Background: Eclamptic seizure not only affects maternal health but may predispose low APGAR scores and development of perinatal asphyxia and thereby influence perinatal mortality too. This study was carried out to evaluate the correlation... more
Background: Eclamptic seizure not only affects maternal health but may predispose low APGAR scores and development of perinatal asphyxia and thereby influence perinatal mortality too. This study was carried out to evaluate the correlation of the interval between the onset of seizure and delivery with the APGAR scores (at 1 minute and 5 minutes) and perinatal asphyxia of the neonates of the eclamptic mothers.Methods: A prospective, cross-sectional, observational, epidemiological study was conducted from April, 2012 to March, 2013 at a tertiary-care Government teaching hospital catering rural population of Eastern India. The participants comprised of 100 consecutive admitted eclamptic mothers and neonates born to them.Results: Majority of mothers were unbooked, primigravidae (86%), aged below 20 years (66 %). Significant inverse correlation was observed between seizure to delivery interval and Apgar scores (1 min and 5 minutes), while seizure to delivery interval >12 hours was foun...
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Iron is important for brain development and cognitive function. Iron deficiency may cause alteration of neurotransmitters and may be manifested by different central nervous system disorders including attention deficit hyperactivity... more
Iron is important for brain development and cognitive function. Iron deficiency may cause alteration of neurotransmitters and may be manifested by different central nervous system disorders including attention deficit hyperactivity disorder (ADHD). As studies are scarce in the Indian context, we had undertaken this study to find out the association between iron deficiency and ADHD. Hospital-based cross-sectional study. Hematological parameters indicating iron status (hemoglobin [Hb], ferritin, Iron, total iron binding capacity [TIBC], mean corpuscular volume [MCV], and mean corpuscular Hb [MCH]) were measured among 119 ADHD patients selected by complete enumeration method and 119 controls. Shapiro-Wilk test, Mann-Whitney U-test, Spearman's correlation, and binary logistic regression were used. < 0.01 was taken as statistically significant. Hb, iron, ferritin, MCV, and MCH were lower among cases and negatively correlated to ADHD, while reverse is true for TIBC and ADHD. Iron d...
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This case report describes the findings of a 10-year-old female child admitted with fever and headache for 3 days along with several episodes of vomiting and generalized seizures for 1 day. She regained consciousness 50 minutes after... more
This case report describes the findings of a 10-year-old female child admitted with fever and headache for 3 days along with several episodes of vomiting and generalized seizures for 1 day. She regained consciousness 50 minutes after admission with initial treatment, but developed muscle weakness, followed by tetraplegia with areflexia, bilateral facial palsy and respiratory insufficiency. The nerve conduction study (NCV) had evidence of demyelinating neuropathy and the cerebrospinal fluid (CSF) showed albumin-cytological dissociation. These neurologic findings were consistent with the diagnosis of Guillain-Barré syndrome. The patient was treated with immunoglobulin and other supportive cares. Mechanical ventilation was started on day 3 of hospital admission in face of respiratory insuficiency. Recovery, however, was relatively quick and extubation was possible on 6th day. Work up for CNS infection was non-contributory. MRI of brain done during the course, revealed an archnoid cyst ...
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Background: Neurocysticercosis (NCC) is a common, widely prevalent parasitic infestation of the central nervous system in children of developing countries leading to neurological morbidities. Objectives: To study the variability of... more
Background: Neurocysticercosis (NCC) is a common, widely prevalent parasitic infestation of the central nervous system in children of developing countries leading to neurological morbidities. Objectives: To study the variability of initial clinical presentations and brain imaging findings in children with NCC in the rural population of West Bengal. Methods: A retrospective analysis was done in the Department of Pediatric Medicine, Burdwan Medical College, Burdwan, India from August 2011 to August 2013. Results: Out of 952 admitted children with seizure, 113 children were diagnosed as having NCC (11.9%). Out of them, 62 (54.9%) were boys and 51 (45.1%) were girls. The age of presentation varied from 3 years to 12 years, with mean age 9.4 years. The commonest age of presentation was between 10 to 12 years (n=62; 54.9%). The maximum number of patients were from Burdwan district (n=72; 63.7%) followed by Birbhum (n=25; 22.1%). The commonest initial presentation with seizure (n=93; 82.3 ...
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Kinetics of aqua ligand substitution from cis-[Ru(bpy)2(H2O)2]2+ by three vicinal dioximes, namely dimethylglyoxime (L1H), 1,2-cyclohexane dionedioxime (L2H) and α-furil dioxime (L3H) have been studied spectrophotometrically in the... more
Kinetics of aqua ligand substitution from cis-[Ru(bpy)2(H2O)2]2+ by three vicinal dioximes, namely dimethylglyoxime (L1H), 1,2-cyclohexane dionedioxime (L2H) and α-furil dioxime (L3H) have been studied spectrophotometrically in the 45–60 °C temperature range. The rate constants increase with increasing dioxime concentration and approach a limiting condition. We propose the following rate law for the reaction in the 3.5–5.5 pH range: $$ {\text{Rate }}
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Lissencephaly or azyria, a rare disorder characterised by the absence of cerebral convolutions and poorly formed sylvlan fissures giving the appearance of a foetal brain with smooth cerebral surface, thickened cortical mantle and... more
Lissencephaly or azyria, a rare disorder characterised by the absence of cerebral convolutions and poorly formed sylvlan fissures giving the appearance of a foetal brain with smooth cerebral surface, thickened cortical mantle and microscopic appearance ofincomplete neuronal migration. It is to consider lissencephaly in the diagnosis of developmental delay with seizure disorder as many patients may be diagnosed as cerebral palsy. Several lissencephaly syndrome have been described, Here three cases of lissencephaly with developmental delay and Intractable seizures are reported.
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Acute dacryocystitis at or shortly after birth is uncommon and its main complication, formation of lacrimal sac abscess, is rare. Uniform and standard treatment protocol for this condition has not been established till date. We report on... more
Acute dacryocystitis at or shortly after birth is uncommon and its main complication, formation of lacrimal sac abscess, is rare. Uniform and standard treatment protocol for this condition has not been established till date. We report on a 2 month old infant with an abscess of the lacrimal sac. He was treated for similar condition on day 6 of his life by incision and drainage; unfortunately, the condition recurs. This time, he was managed with incision and drainage under systemic antibiotic cover; and an early probing of the nasolacrimal duct (NLD) was done on 7th post-operative day. The patient was followed up for a period of one year without any further recurrence and complication. Pathophysiology of the condition and possible treatment options in children have been discussed.DOI: http://dx.doi.org/10.3126/ajms.v6i2.10458Asian Journal of Medical Sciences Vol.6(2) 2015 121-123
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Sacrococcygeal teratoma (SCT), although rare, is the most common congenital neoplasm in neonates. A mass in the sacrococcygeal region at the time of birth is the usual presentation. Routine antenatal abdominal ultrasound of mother can... more
Sacrococcygeal teratoma (SCT), although rare, is the most common congenital neoplasm in neonates. A mass in the sacrococcygeal region at the time of birth is the usual presentation. Routine antenatal abdominal ultrasound of mother can detect almost all the cases. The prognosis is favorable when diagnosis is done antenatally and proper management is instituted soon after the baby is born. Presented herein a 2 days old neonate with a neglected SCT who died unfortunately due to massive bleeding from the tumor. A brief review of the literature has been presented to make everyone aware of the condition so that future recurrence of such sad events may be avoided.DOI: http://dx.doi.org/10.3126/ajms.v6i2.10448Asian Journal of Medical Sciences Vol.6(2) 2015 108-110
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Abstract The kinetics of the aqua ligand substitution from hydroxopentaaquarhodium(III) ion, [Rh(H2O)5(OH)]2?, by L-Arginine has been studied spectrophotometrically as a function of Arginine concentration, and temperature, at pH 4.3. The... more
Abstract The kinetics of the aqua ligand substitution from hydroxopentaaquarhodium(III) ion, [Rh(H2O)5(OH)]2?, by L-Arginine has been studied spectrophotometrically as a function of Arginine concentration, and temperature, at pH 4.3. The reaction proceeds via a rapid outer sphere ...