Background: The mass vaccination campaign against SARS-CoV-2 was started in Tunisia on 13 March 2... more Background: The mass vaccination campaign against SARS-CoV-2 was started in Tunisia on 13 March 2021 by using progressively seven different vaccines approved for emergency use. Herein, we aimed to evaluate the humoral and cellular immunity in subjects aged 40 years and over who received one of the following two-dose regimen vaccines against SARS-CoV-2, namely mRNA-1273 or Spikevax (Moderna), BNT162B2 or Comirnaty (Pfizer-BioNTech), Gam-COVID-Vac or Sputnik V (Gamaleya Research Institute), ChAdOx1-S or Vaxzevria (AstraZeneca), BIBP (Sinopharm), and Coronavac (Sinovac). Material and methods: For each type of vaccine, a sample of subjects aged 40 and over was randomly selected from the national platform for monitoring COVID-19 vaccination and contacted to participate to this study. All consenting participants were sampled for peripheral blood at 3–7 weeks after the second vaccine dose to perform anti-S and anti-N serology by the Elecsys® (Lenexa, KS, USA) anti-SARS-CoV-2 assays (Roche®...
Introduction: The objectives of our work were to compare the serum concentrations of lipid parame... more Introduction: The objectives of our work were to compare the serum concentrations of lipid parameters,insulin, resistin, ghrelin, zinc and magnesium between two groups of men with obese type 2 diabetes and a control group and to study possible correlations between these differentparameters. Material and methods: This was a monocentric case-control study during the period 19 October 2015 to 18 November 2015. It included biological parameters from two separate samples: a group of 41 male, obese, type 2 diabetic patients and a group of 34 diabetes-free controls. Results: Mean plasma ghrelin concentrations were significantly lower in patients with type 2 diabetes compared to those in the control group: (14.05 ± 2.35 pg/mL) versus (45.45 ± 13.59 pg/mL). Mean resistance was significantly higher in diabetics (10.09 ± 2.63 ng/mL) compared to healthy subjects (2.22 ± 0.58 ng/mL). In multivariate analysis, body mass index (BMI) and insulin levels were factors that could influence zincemia var...
BACKGROUND At the obese ones, there is an imbalance between the free defenses antioxydants and ra... more BACKGROUND At the obese ones, there is an imbalance between the free defenses antioxydants and radicals from where the installation of an oxydative stress, responsible for the development of non-insulin-dependent diabetes. AIM Our objectives was to evaluate the levels of vitamins A, E and of leptin, to search the link witch could exist between vitamins and leptin. METHODOLOGY We proportioned the rates in vitamins A, E and in leptine at 30 obese subjects diabetic of type 2 including 12 men and 18 women of average age (50.93 +/- 6.13) years not carrying pathologies other than the diabetes and obesity compared to 30 witnesses who theirs are paired according to the age and the sex.. RESULTS Our results chows that levels of antioxidants did not differ between the two groups but we find a non significant decrease in vitamin E/(TC +TG) ratio (1.86 +/- 0.38 vs. 2.11 +/- 0.74 ; p = 0.08) and significant increase of vitamin A level in women obese with non-insulin-diabetes mellitus compared wi...
BACKGROUND Frequent screening of renal failure and good glycaemic control in diabetic patients ca... more BACKGROUND Frequent screening of renal failure and good glycaemic control in diabetic patients can avoid this severe complication. AIM To evaluate the frequency of renal failure and the associated risk factors among type 2 diabetic Tunisian in-patients. Glomerular filtration rate was estimated using the Cockcroft-Gault formula. Renal failure was diagnosed on figure of glomerular filtration rate inferior than 60 ml/min. RESULTS Six hundred eighty-nine patients were included. The sex ratio was 0.65. The mean age was 60 ± 11 years. The frequency of renal failure was 19.8% (137 patients) with dominance of a moderate form defined by a glomerular filtration rate between 30 and 59 ml/min (82.5% of patients). Patients with renal failure were older and less obese than diabetic patients without this complication (p<0.00001 and 0.02 respectively). The duration of both diabetes and hypertension was higher in presence of renal failure (p=0.0001 and p<0.001 respectively). Patients with rena...
UNLABELLED The aims of the study were to study the distribution of cholesterol and triglycerides ... more UNLABELLED The aims of the study were to study the distribution of cholesterol and triglycerides and to assess the prevalence of dyslipemia in Tunisian adult population. METHODS The Tunisian National Nutrition Survey (TNNS) was a cross sectional study performed on a total of 7860 adult subjects and was conducted on 1996-1997. The TNNS included 3087 adults over 20 years old. RESULTS The mean values of cholesterol (CT) were more elevated in urban than rural area (p<0.001), and in females than in males (p<0.007). The overall prevalence of hypercholesterolemia (CT > 6.2 mmol/l) was 8.4% and that of hypertriglyceridemia (TG > 1.70 mmol/l) was 21%. The prevalence of borderline high cholesterol (> or =5.2-< 6.2 mmol/l) was 17%; These prevalences were more elevated in urban than rural areas (p <0.001) and increased with age in both genders (p < 0.001). The multiple adjusted odd ratio of the prevalence of hypercholesterolemia showed a positive correlation with female ...
BACKGROUND The prevalence of obesity in children is known to be increasing rapidly worldwide but ... more BACKGROUND The prevalence of obesity in children is known to be increasing rapidly worldwide but few population-based surveys have been undertaken in North Africa and in the Middle East. AIMS Report the means of body mass index with values corresponding to the different percentiles in boys and girls by age from a large nationally representative sample of the Tunisian children population. The second aim was to estimate the prevalence of obesity and over weight in children and adolescent using the 85th and 95th body mass index percentile respectively derived from the U.S.A. first National Health and Nutrition Survey and also the International cut off points for body mass index for overweight and obesity proposed by the International Obesity Task Force and Rolland Cachera. SUBJECTS AND METHODS We have used data from the Tunisian National Nutrition Survey, a cross sectional health study providing a large nationally representative sample of the Tunisian population including 3885 children...
Actuellement, il est etabli qu'une elevation du taux de LDL (Low Density Lipoprotein) et une ... more Actuellement, il est etabli qu'une elevation du taux de LDL (Low Density Lipoprotein) et une reduction du taux de HDL (High Density Lipoprotein) sont correlees avec l'augmentation des risques 'atherosclerose et de n maladies coronariennes. Une augmentation du taux de HDL joue un role protecteur dans l'atherosclerose. D'autre part, l'hypertension arterielle constitue une cause majeure ainsi qu'un facteur aggravant de l'atherosclerose. La consommation d'ail semble avoir un effet benefique a long terme, consommation pour des durees superieures a 5 mois, dans la prevention des maladies cardio-vasculaires. Le butde ce travail est de rechercher la nature de l'action de l'ail a court terme dans deux groupes de sujets volontaires : un premier groupe normolipidemique (16 hommes et 15 femmes) et un deuxieme groupe hyper-cholesterolemique (10 hommes et 10 femmes) ont recu une dose de 5,6 g d'ail frais par jour pendant une periode de 15 jours. Nos...
The elaboration of a causal model is useful to conceptualise determinants of a nutritional proble... more The elaboration of a causal model is useful to conceptualise determinants of a nutritional problem and identify information needs to validate the model. We applied this approach to the iron deficiency anaemia, an important public health problem in Tunisia in women and pre-school children. A multidisciplinary group constructed the causal model as part of a project to set up a nutrition and food surveillance system in Tunisia. The causal model allows distinguishing four principal branches corresponding to four main groups of aetiologies leading to iron deficiency, namely iron intake, iron absorption and/or bio availability, chronic iron loss, and physiologic increase in iron need. Each main factor was decomposed in several underlying determinants. The conceptual model, with its hierarchical construction of determinants, allows now to identify indicators to measure the determinants of iron deficiency anaemia in the Tunisian context. In a following step the most important indicators can...
L'objectif essentiel de ce travail etait d'etudier le desordre des parametres lipidiques ... more L'objectif essentiel de ce travail etait d'etudier le desordre des parametres lipidiques (cholesterol, triglycerides, HDL, LDL, ApoA1 et ApoB) et des parametres hormonaux (Leptine/insuline) chez les enfants obeses qui vivent dans un environnement bien determine. Notre etude a porte sur 63 enfants obeses et 52 enfants non obeses en âge de pre-puberte. Ces enfants sont recrutes a partir d'un echantillon de 3148 enfants. Nous avons trouve que les moyennes des parametres lipidiques sont significativement plus elevees chez les enfants obeses, a l'exception de la glycemie a jeun, ou il n'y a pas de difference significative entre les obeses et les non obeses. La leptinemie et l'insulinemie sont significativement superieures chez les enfants obeses. Chez les filles obeses, la leptinemie est significativement plus elevee par rapport aux garcons obeses. L'analyse multivariee en regression logistique a montre que seule la leptine est apparue comme facteur de risque ...
BACKGROUND The genes encoding renin-angiotensin system (RAS) components are potent candidate gene... more BACKGROUND The genes encoding renin-angiotensin system (RAS) components are potent candidate genes in both hypertension and diabetes namely ACE encoding the angiotensin converting enzyme and AGT encoding angiotensinogen. It has been suggested that the insertion/deletion (I/D) polymorphism in intron 16 of ACE gene is associated with ACE levels, and M235T gene polymorphism is associated with plasma AGT levels. AIM We examined in this report the association between ACE I/D and AGT M235T polymorphisms with hypertension status in Tunisian type 2 diabetic subjects. METHODS Thirty nine hypertensive and 22 normotensive type 2 diabetic Tunisian patients were recruited for this study. The I/D polymorphism of ACE gene was analysed with nested PCR in order to avoid mistyping heterozygous individuals and the M235T polymorphism of AGT gene was analysed using PCR and allele specific restriction. RESULTS The distribution of DD, ID and II genotypes did not significantly differ between type 2 diabeti...
Abstracts 173 with prolactinomas as well as weight loss associated with dopaminergic treatment. T... more Abstracts 173 with prolactinomas as well as weight loss associated with dopaminergic treatment. This work aims to assess the prevalence of obesity in patients with macroprolactinomas, before and after treatment with bromocriptin, and identify some determinants of weight variation during follow-up. Methods: Medical records of patients with macroprolactinomas, treated with bromocriptin for ≥2 years, were retrospectively reviewed. Analyzed: tumor size; prolactin; anthropometric data; persistent hypogonadism and bromocriptin doses. Statistical analyses:SPSS(21). Results: There were 87 eligible patients, 53 women, with 40.67 ± 15.44years. Initial obesity prevalence was 41.3% [class I:24,1%; class II:11,5%; class III:5,7%]. One third of the patients (n = 29) had persistent hypogonadism, although these didn’t present initial higher prolactin levels or an association with obesity (p > 0.05). The median bromocriptin cumulative dose was 15432.78 (1825–81395)mg, over 8.04 ± 5.56years. Most ...
Prerequis: L'insuffisance renale chez le diabetique peut etre prevenue ou retardee grâce a un... more Prerequis: L'insuffisance renale chez le diabetique peut etre prevenue ou retardee grâce a une surveillance reguliere et un controle glycemique strict. But: Estimer la frequence de l'insuffisance renale chez des diabetiques de type 2 tunisiens hospitalises dans un service de diabetologie et d'analyser les facteurs associes. Methodes: Six cent quatre-vingt-neuf patients ont ete inclus dans notre etude. L'insuffisance renale a ete definie par une clearance de la creatinemie calculee selon la formule de Cockcroft et Gault inferieure a 60 ml/ min. L'âge moyen etait de 60 ± 11 ans avec un sex ratio de 0,65. Resultats: Cent trente sept patients (19,8%) avaient une insuffisance renale. Elle etait de type moderee dans 82,5% des cas (clearance de la creatinine entre 30 et 59 ml/min). Les patients insuffisants renaux etaient plus âges et moins obeses (p<0,00001 et 0,02 respectivement) que les patients indemnes. Une HTA etait retrouvee chez 84,6 % d'entre eux (p<0...
Les objectifs de l'etude sont d'etudier la distribution des lipides seriques et d'eva... more Les objectifs de l'etude sont d'etudier la distribution des lipides seriques et d'evaluer la prevalence des hyperlipidemies dans la population Tunisienne adulte. Methodes: L'Enquete Nationale de Nutrition est une enquete transversale sur echantillon representatif de la population Tunisienne (n = 7860). Elle s'est deroulee de 1996 a 1997. Ont participe a l'etude 3687 sujets âges de plus de 20 ans. Resultats: Les moyennes du cholesterol total (CT) et des triglycerides (TG) sont plus elevees en milieu urbain qu'en milieu rural (p 6,2 mmol/l) est de 8,4%, celle de l'hypertriglyceridemie (TG > 1,70 mmol/l) est de 21%. La prevalence du cholesterol limite haute (≥ 5,2 - < 6.2 mmol/l) est de 17%. Ces prevalences respectives sont significativement plus elevees en milieu urbain qu'en milieu rural (p < 0,001) et augmentent avec l'âge (p < 0,001) dans les deux sexes. Les principaux facteurs predictifs de l'hypercholesterolemie sont le sexe...
This study was designed to assess the effects of fasting during Ramadan on weight, blood pressure... more This study was designed to assess the effects of fasting during Ramadan on weight, blood pressure, metabolic control and plasma lipoproteins in diabetic patients. This study was conducted in December 2000 (Ramadan 1421) when the length of fasting was 12 hours a day. It included 38 type 2 diabetic patients (20 males and 18 females). Mean patient age was 51.410.5 years and mean body mass index (BMI) 28.94.7kg/m2. Three patients were treated with diet and 35 with oral hypoglycemic agents. Clinical and biochemical parameters were evaluated during three periods: three weeks before Ramadan (T0), at the fourth week of Ramadan (T1) and three weeks after the end of Ramadan (T2). During the month of Ramadan, a decrease in weight (0.52kg) and no change in blood pressure were observed. No metabolic complication occurred in our patients. A significant effect of Ramadan fasting was observed on glycemic control and lipoprotein levels. In patients whose fructosamine level before Ramadan was higher ...
The Journal of sports medicine and physical fitness, Jan 11, 2016
To evaluate the effect of two types of partial sleep deprivation (PSD) on biomarkers of muscle an... more To evaluate the effect of two types of partial sleep deprivation (PSD) on biomarkers of muscle and cardiac injuries in response to acute intermittent exercise in professional athletes. In a counterbalanced order, Ten healthy male Taekwondo athletes were asked to perform the Yo-Yo Intermittent Recovery Test (YYIRT) in three conditions, allowing a 36 h recovery period in between: i) following a full night of habitual sleep known as a reference sleep night (RN); ii) following PSD in the beginning of the night (PSDBN), and iii) following PSD in the end of the night (PSDEN). Heart rate (HR) and arterial oxygen saturation (SaO2) were measured during exercise. Blood samples were taken just before and 3 min after the YYIRT to measure biomarkers related to muscle and cardiac injuries. No significant effect of PSD was observed for physiological parameters (i.e., HR and SaO2). However, a significant alteration of resting ultra-sensitive C-reactive protein (P < 0.05) and myoglobin (MYO) (P &...
Revue d'épidémiologie et de santé publique, 1996
Cardiovascular risk factors were studied in a random sample from the urban and rural population o... more Cardiovascular risk factors were studied in a random sample from the urban and rural population of the Cap-Bon, including 692 men and women, aged 35-50 years. In this sample, including 56 % urban dwellers, the mean total cholesterol was higher in urban areas (4.64 mmol/l) than in rural areas (4.16 mmol/l). In urban areas 10.2 % of the subjects had values above 6.2 mmol/l compared with 6.6 % in rural areas. Obesity was much more frequent among women (35.2 % versus 26.3 %) but less frequent among men (16.0 % versus 5.4 %) in urban and rural areas. Diabetes was found in 8.8 % of men and 10.4 % of women in urban areas, and only 0.8 % and 3.9 % in rural areas. Hypertension was found in 13.8 % of women and 11.6 % of men in urban areas, 13.3 % and 4.0 % in rural areas (13.3 %). Cigarette smoking was found in 60.7 % of men in urban areas and 75.8 % in rural areas (p < 0.05).
Background: The mass vaccination campaign against SARS-CoV-2 was started in Tunisia on 13 March 2... more Background: The mass vaccination campaign against SARS-CoV-2 was started in Tunisia on 13 March 2021 by using progressively seven different vaccines approved for emergency use. Herein, we aimed to evaluate the humoral and cellular immunity in subjects aged 40 years and over who received one of the following two-dose regimen vaccines against SARS-CoV-2, namely mRNA-1273 or Spikevax (Moderna), BNT162B2 or Comirnaty (Pfizer-BioNTech), Gam-COVID-Vac or Sputnik V (Gamaleya Research Institute), ChAdOx1-S or Vaxzevria (AstraZeneca), BIBP (Sinopharm), and Coronavac (Sinovac). Material and methods: For each type of vaccine, a sample of subjects aged 40 and over was randomly selected from the national platform for monitoring COVID-19 vaccination and contacted to participate to this study. All consenting participants were sampled for peripheral blood at 3–7 weeks after the second vaccine dose to perform anti-S and anti-N serology by the Elecsys® (Lenexa, KS, USA) anti-SARS-CoV-2 assays (Roche®...
Introduction: The objectives of our work were to compare the serum concentrations of lipid parame... more Introduction: The objectives of our work were to compare the serum concentrations of lipid parameters,insulin, resistin, ghrelin, zinc and magnesium between two groups of men with obese type 2 diabetes and a control group and to study possible correlations between these differentparameters. Material and methods: This was a monocentric case-control study during the period 19 October 2015 to 18 November 2015. It included biological parameters from two separate samples: a group of 41 male, obese, type 2 diabetic patients and a group of 34 diabetes-free controls. Results: Mean plasma ghrelin concentrations were significantly lower in patients with type 2 diabetes compared to those in the control group: (14.05 ± 2.35 pg/mL) versus (45.45 ± 13.59 pg/mL). Mean resistance was significantly higher in diabetics (10.09 ± 2.63 ng/mL) compared to healthy subjects (2.22 ± 0.58 ng/mL). In multivariate analysis, body mass index (BMI) and insulin levels were factors that could influence zincemia var...
BACKGROUND At the obese ones, there is an imbalance between the free defenses antioxydants and ra... more BACKGROUND At the obese ones, there is an imbalance between the free defenses antioxydants and radicals from where the installation of an oxydative stress, responsible for the development of non-insulin-dependent diabetes. AIM Our objectives was to evaluate the levels of vitamins A, E and of leptin, to search the link witch could exist between vitamins and leptin. METHODOLOGY We proportioned the rates in vitamins A, E and in leptine at 30 obese subjects diabetic of type 2 including 12 men and 18 women of average age (50.93 +/- 6.13) years not carrying pathologies other than the diabetes and obesity compared to 30 witnesses who theirs are paired according to the age and the sex.. RESULTS Our results chows that levels of antioxidants did not differ between the two groups but we find a non significant decrease in vitamin E/(TC +TG) ratio (1.86 +/- 0.38 vs. 2.11 +/- 0.74 ; p = 0.08) and significant increase of vitamin A level in women obese with non-insulin-diabetes mellitus compared wi...
BACKGROUND Frequent screening of renal failure and good glycaemic control in diabetic patients ca... more BACKGROUND Frequent screening of renal failure and good glycaemic control in diabetic patients can avoid this severe complication. AIM To evaluate the frequency of renal failure and the associated risk factors among type 2 diabetic Tunisian in-patients. Glomerular filtration rate was estimated using the Cockcroft-Gault formula. Renal failure was diagnosed on figure of glomerular filtration rate inferior than 60 ml/min. RESULTS Six hundred eighty-nine patients were included. The sex ratio was 0.65. The mean age was 60 ± 11 years. The frequency of renal failure was 19.8% (137 patients) with dominance of a moderate form defined by a glomerular filtration rate between 30 and 59 ml/min (82.5% of patients). Patients with renal failure were older and less obese than diabetic patients without this complication (p<0.00001 and 0.02 respectively). The duration of both diabetes and hypertension was higher in presence of renal failure (p=0.0001 and p<0.001 respectively). Patients with rena...
UNLABELLED The aims of the study were to study the distribution of cholesterol and triglycerides ... more UNLABELLED The aims of the study were to study the distribution of cholesterol and triglycerides and to assess the prevalence of dyslipemia in Tunisian adult population. METHODS The Tunisian National Nutrition Survey (TNNS) was a cross sectional study performed on a total of 7860 adult subjects and was conducted on 1996-1997. The TNNS included 3087 adults over 20 years old. RESULTS The mean values of cholesterol (CT) were more elevated in urban than rural area (p<0.001), and in females than in males (p<0.007). The overall prevalence of hypercholesterolemia (CT > 6.2 mmol/l) was 8.4% and that of hypertriglyceridemia (TG > 1.70 mmol/l) was 21%. The prevalence of borderline high cholesterol (> or =5.2-< 6.2 mmol/l) was 17%; These prevalences were more elevated in urban than rural areas (p <0.001) and increased with age in both genders (p < 0.001). The multiple adjusted odd ratio of the prevalence of hypercholesterolemia showed a positive correlation with female ...
BACKGROUND The prevalence of obesity in children is known to be increasing rapidly worldwide but ... more BACKGROUND The prevalence of obesity in children is known to be increasing rapidly worldwide but few population-based surveys have been undertaken in North Africa and in the Middle East. AIMS Report the means of body mass index with values corresponding to the different percentiles in boys and girls by age from a large nationally representative sample of the Tunisian children population. The second aim was to estimate the prevalence of obesity and over weight in children and adolescent using the 85th and 95th body mass index percentile respectively derived from the U.S.A. first National Health and Nutrition Survey and also the International cut off points for body mass index for overweight and obesity proposed by the International Obesity Task Force and Rolland Cachera. SUBJECTS AND METHODS We have used data from the Tunisian National Nutrition Survey, a cross sectional health study providing a large nationally representative sample of the Tunisian population including 3885 children...
Actuellement, il est etabli qu'une elevation du taux de LDL (Low Density Lipoprotein) et une ... more Actuellement, il est etabli qu'une elevation du taux de LDL (Low Density Lipoprotein) et une reduction du taux de HDL (High Density Lipoprotein) sont correlees avec l'augmentation des risques 'atherosclerose et de n maladies coronariennes. Une augmentation du taux de HDL joue un role protecteur dans l'atherosclerose. D'autre part, l'hypertension arterielle constitue une cause majeure ainsi qu'un facteur aggravant de l'atherosclerose. La consommation d'ail semble avoir un effet benefique a long terme, consommation pour des durees superieures a 5 mois, dans la prevention des maladies cardio-vasculaires. Le butde ce travail est de rechercher la nature de l'action de l'ail a court terme dans deux groupes de sujets volontaires : un premier groupe normolipidemique (16 hommes et 15 femmes) et un deuxieme groupe hyper-cholesterolemique (10 hommes et 10 femmes) ont recu une dose de 5,6 g d'ail frais par jour pendant une periode de 15 jours. Nos...
The elaboration of a causal model is useful to conceptualise determinants of a nutritional proble... more The elaboration of a causal model is useful to conceptualise determinants of a nutritional problem and identify information needs to validate the model. We applied this approach to the iron deficiency anaemia, an important public health problem in Tunisia in women and pre-school children. A multidisciplinary group constructed the causal model as part of a project to set up a nutrition and food surveillance system in Tunisia. The causal model allows distinguishing four principal branches corresponding to four main groups of aetiologies leading to iron deficiency, namely iron intake, iron absorption and/or bio availability, chronic iron loss, and physiologic increase in iron need. Each main factor was decomposed in several underlying determinants. The conceptual model, with its hierarchical construction of determinants, allows now to identify indicators to measure the determinants of iron deficiency anaemia in the Tunisian context. In a following step the most important indicators can...
L'objectif essentiel de ce travail etait d'etudier le desordre des parametres lipidiques ... more L'objectif essentiel de ce travail etait d'etudier le desordre des parametres lipidiques (cholesterol, triglycerides, HDL, LDL, ApoA1 et ApoB) et des parametres hormonaux (Leptine/insuline) chez les enfants obeses qui vivent dans un environnement bien determine. Notre etude a porte sur 63 enfants obeses et 52 enfants non obeses en âge de pre-puberte. Ces enfants sont recrutes a partir d'un echantillon de 3148 enfants. Nous avons trouve que les moyennes des parametres lipidiques sont significativement plus elevees chez les enfants obeses, a l'exception de la glycemie a jeun, ou il n'y a pas de difference significative entre les obeses et les non obeses. La leptinemie et l'insulinemie sont significativement superieures chez les enfants obeses. Chez les filles obeses, la leptinemie est significativement plus elevee par rapport aux garcons obeses. L'analyse multivariee en regression logistique a montre que seule la leptine est apparue comme facteur de risque ...
BACKGROUND The genes encoding renin-angiotensin system (RAS) components are potent candidate gene... more BACKGROUND The genes encoding renin-angiotensin system (RAS) components are potent candidate genes in both hypertension and diabetes namely ACE encoding the angiotensin converting enzyme and AGT encoding angiotensinogen. It has been suggested that the insertion/deletion (I/D) polymorphism in intron 16 of ACE gene is associated with ACE levels, and M235T gene polymorphism is associated with plasma AGT levels. AIM We examined in this report the association between ACE I/D and AGT M235T polymorphisms with hypertension status in Tunisian type 2 diabetic subjects. METHODS Thirty nine hypertensive and 22 normotensive type 2 diabetic Tunisian patients were recruited for this study. The I/D polymorphism of ACE gene was analysed with nested PCR in order to avoid mistyping heterozygous individuals and the M235T polymorphism of AGT gene was analysed using PCR and allele specific restriction. RESULTS The distribution of DD, ID and II genotypes did not significantly differ between type 2 diabeti...
Abstracts 173 with prolactinomas as well as weight loss associated with dopaminergic treatment. T... more Abstracts 173 with prolactinomas as well as weight loss associated with dopaminergic treatment. This work aims to assess the prevalence of obesity in patients with macroprolactinomas, before and after treatment with bromocriptin, and identify some determinants of weight variation during follow-up. Methods: Medical records of patients with macroprolactinomas, treated with bromocriptin for ≥2 years, were retrospectively reviewed. Analyzed: tumor size; prolactin; anthropometric data; persistent hypogonadism and bromocriptin doses. Statistical analyses:SPSS(21). Results: There were 87 eligible patients, 53 women, with 40.67 ± 15.44years. Initial obesity prevalence was 41.3% [class I:24,1%; class II:11,5%; class III:5,7%]. One third of the patients (n = 29) had persistent hypogonadism, although these didn’t present initial higher prolactin levels or an association with obesity (p > 0.05). The median bromocriptin cumulative dose was 15432.78 (1825–81395)mg, over 8.04 ± 5.56years. Most ...
Prerequis: L'insuffisance renale chez le diabetique peut etre prevenue ou retardee grâce a un... more Prerequis: L'insuffisance renale chez le diabetique peut etre prevenue ou retardee grâce a une surveillance reguliere et un controle glycemique strict. But: Estimer la frequence de l'insuffisance renale chez des diabetiques de type 2 tunisiens hospitalises dans un service de diabetologie et d'analyser les facteurs associes. Methodes: Six cent quatre-vingt-neuf patients ont ete inclus dans notre etude. L'insuffisance renale a ete definie par une clearance de la creatinemie calculee selon la formule de Cockcroft et Gault inferieure a 60 ml/ min. L'âge moyen etait de 60 ± 11 ans avec un sex ratio de 0,65. Resultats: Cent trente sept patients (19,8%) avaient une insuffisance renale. Elle etait de type moderee dans 82,5% des cas (clearance de la creatinine entre 30 et 59 ml/min). Les patients insuffisants renaux etaient plus âges et moins obeses (p<0,00001 et 0,02 respectivement) que les patients indemnes. Une HTA etait retrouvee chez 84,6 % d'entre eux (p<0...
Les objectifs de l'etude sont d'etudier la distribution des lipides seriques et d'eva... more Les objectifs de l'etude sont d'etudier la distribution des lipides seriques et d'evaluer la prevalence des hyperlipidemies dans la population Tunisienne adulte. Methodes: L'Enquete Nationale de Nutrition est une enquete transversale sur echantillon representatif de la population Tunisienne (n = 7860). Elle s'est deroulee de 1996 a 1997. Ont participe a l'etude 3687 sujets âges de plus de 20 ans. Resultats: Les moyennes du cholesterol total (CT) et des triglycerides (TG) sont plus elevees en milieu urbain qu'en milieu rural (p 6,2 mmol/l) est de 8,4%, celle de l'hypertriglyceridemie (TG > 1,70 mmol/l) est de 21%. La prevalence du cholesterol limite haute (≥ 5,2 - < 6.2 mmol/l) est de 17%. Ces prevalences respectives sont significativement plus elevees en milieu urbain qu'en milieu rural (p < 0,001) et augmentent avec l'âge (p < 0,001) dans les deux sexes. Les principaux facteurs predictifs de l'hypercholesterolemie sont le sexe...
This study was designed to assess the effects of fasting during Ramadan on weight, blood pressure... more This study was designed to assess the effects of fasting during Ramadan on weight, blood pressure, metabolic control and plasma lipoproteins in diabetic patients. This study was conducted in December 2000 (Ramadan 1421) when the length of fasting was 12 hours a day. It included 38 type 2 diabetic patients (20 males and 18 females). Mean patient age was 51.410.5 years and mean body mass index (BMI) 28.94.7kg/m2. Three patients were treated with diet and 35 with oral hypoglycemic agents. Clinical and biochemical parameters were evaluated during three periods: three weeks before Ramadan (T0), at the fourth week of Ramadan (T1) and three weeks after the end of Ramadan (T2). During the month of Ramadan, a decrease in weight (0.52kg) and no change in blood pressure were observed. No metabolic complication occurred in our patients. A significant effect of Ramadan fasting was observed on glycemic control and lipoprotein levels. In patients whose fructosamine level before Ramadan was higher ...
The Journal of sports medicine and physical fitness, Jan 11, 2016
To evaluate the effect of two types of partial sleep deprivation (PSD) on biomarkers of muscle an... more To evaluate the effect of two types of partial sleep deprivation (PSD) on biomarkers of muscle and cardiac injuries in response to acute intermittent exercise in professional athletes. In a counterbalanced order, Ten healthy male Taekwondo athletes were asked to perform the Yo-Yo Intermittent Recovery Test (YYIRT) in three conditions, allowing a 36 h recovery period in between: i) following a full night of habitual sleep known as a reference sleep night (RN); ii) following PSD in the beginning of the night (PSDBN), and iii) following PSD in the end of the night (PSDEN). Heart rate (HR) and arterial oxygen saturation (SaO2) were measured during exercise. Blood samples were taken just before and 3 min after the YYIRT to measure biomarkers related to muscle and cardiac injuries. No significant effect of PSD was observed for physiological parameters (i.e., HR and SaO2). However, a significant alteration of resting ultra-sensitive C-reactive protein (P < 0.05) and myoglobin (MYO) (P &...
Revue d'épidémiologie et de santé publique, 1996
Cardiovascular risk factors were studied in a random sample from the urban and rural population o... more Cardiovascular risk factors were studied in a random sample from the urban and rural population of the Cap-Bon, including 692 men and women, aged 35-50 years. In this sample, including 56 % urban dwellers, the mean total cholesterol was higher in urban areas (4.64 mmol/l) than in rural areas (4.16 mmol/l). In urban areas 10.2 % of the subjects had values above 6.2 mmol/l compared with 6.6 % in rural areas. Obesity was much more frequent among women (35.2 % versus 26.3 %) but less frequent among men (16.0 % versus 5.4 %) in urban and rural areas. Diabetes was found in 8.8 % of men and 10.4 % of women in urban areas, and only 0.8 % and 3.9 % in rural areas. Hypertension was found in 13.8 % of women and 11.6 % of men in urban areas, 13.3 % and 4.0 % in rural areas (13.3 %). Cigarette smoking was found in 60.7 % of men in urban areas and 75.8 % in rural areas (p < 0.05).
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