Purpose: This study assessed the performance of International Classification of Diseases 10th Rev... more Purpose: This study assessed the performance of International Classification of Diseases 10th Revision, Clinical Modification (ICD-10-CM) coronavirus disease 2019 (COVID-19) diagnostic code U07.1 against polymerase chain reaction (PCR) test results (Objective 1), and electronic medical record (EMR)-based codified algorithm for severe COVID-19 illness based on endpoints used in the Pfizer-BioNTech COVID-19 vaccine trial against chart review (Objective 2). Methods: This retrospective, longitudinal cohort study used EMR data from the Mass General Brigham COVID-19 Data Mart (3/1/2020-11/19/2020) for adult patients with ≥1 PCR test, antigen test, or code U07.1 (Objective 1) and adult patients with a positive PCR test hospitalized with COVID-19 (Objective 2). Results: Among 354,124 patients in Objective 1, 96% had ≥1 PCR test (including 6% with ≥1 positive PCR test; 11% with ≥1 code U07.1). Code U07.1 had low sensitivity (54%) and positive predictive value (PPV; 63%) but high specificity ...
Thesis. 1978. Ph.D.--Massachusetts Institute of Technology. Alfred P. Sloan School of Management.... more Thesis. 1978. Ph.D.--Massachusetts Institute of Technology. Alfred P. Sloan School of Management. MICROFICHE COPY AVAILABLE IN ARCHIVES AND DEWEY. Bibliography : leaf 226. Ph.D.
Partial deregulation has occurred in a broad range of industries, from telecommunications to tran... more Partial deregulation has occurred in a broad range of industries, from telecommunications to transportation to financial services.' This first phase of deregulation has given impetus to an intensive debate over future regulatory policy. Some commentators advocate further partial deregulation of industries such as natural gas and electric power2 while others push for re-regulation of airlines and railroads.' The immediate question is whether the deregulation that has taken place will achieve the benefits of market competition or will create instead imperfect markets that are neither fish nor fowl, markets that are less efficient than if they were either fully regulated or fully competitive. The question arises from the inherent nature of partial deregulation, which often maintains price controls and other restrictions on incumbent firms while removing entry barriers. This disparity may cause
The use of computers in health organizations raises questions as to the privacy and confidentiali... more The use of computers in health organizations raises questions as to the privacy and confidentiality of automated information. Results of several site visits are forwarded as a means for establishing the state of the art in medical information systems. The literature on the sub-ject, sparse as it is, is reviewed. Afiframework for analyzing the matter of data security is described. The major problem with medical data see-curity is taken to be the uncertainty surrounding the decision as to the required level and degree of security. In order to investigate the di-mensions of the problem several hypotheses are tested with the aid of a Security Attitude Survey which was administered to a sample of physicians and managers. The results of the questionnaire are analysed and lead to the fol-lowing conclusions. First, physicians, much more so than managers, perceive automated data as more susceptible than other data to either accidental or intentional disclosure, modification or destruction.
This study determined the risk of serious hepatotoxicity resulting in hospitalizations among pati... more This study determined the risk of serious hepatotoxicity resulting in hospitalizations among patients prescribed opioid/acetaminophen combinations. A retrospective cohort study using an insurance claims database was conducted. Adult patients with ≥1 claim for oxycodone/acetaminophen or hydrocodone/acetaminophen combinations were included (N = 1,228,356). A pre-post design was employed to compare serious hepatotoxicity risk before versus after initiation of opioid/acetaminophen combination. Serious hepatotoxicity risk between the opioid/acetaminophen group and a control group of opioid-alone users (N = 11,809) was also examined. Within the opioid/acetaminophen group, risk of hepatotoxicity-related hospitalizations pre- versus post-opioid/acetaminophen treatment was compared using the normal approximation with the binomial distribution. The incidence rate of hepatotoxicity-related hospitalizations for the opioid/acetaminophen group was compared with the opioid-alone group using multivariate Poisson regression adjusting for baseline differences between groups. Of the opioid/acetaminophen cohort, hepatotoxicity-related hospitalization risk in the 6-month post-opioid/acetaminophen period was lower than that in the pre-period with a risk reduction of 1.2 per 10,000 (pre-period = 0.12%; 95% confidence interval [CI], 0.12 to 0.13; post-period = 0.11%; 95% CI, 0.11 to 0.12). In the 12-month period, risk increased in the post-period by 2.4 per 10,000 (pre-period = 0.14%; 95% CI, 0.14 to 0.15; post-period = 0.17%; 95% CI, 0.16 to 0.18). After adjusting for confounders, the opioid-alone group did not demonstrate a lower rate of hepatotoxicity-related hospitalizations than the opioid/acetaminophen group (incidence rate ratio of opioid-alone over opioid/acetaminophen = 2.9; 95% CI, 1.8 to 4.7). There is no population data-based evidence supporting elevated risk of hepatotoxicity-related hospitalization associated with opioid/acetaminophen combinations.
ABSTRACT In a recent issue of this journal, Mingo (1978) analyzed the effect of deposit-rate ceil... more ABSTRACT In a recent issue of this journal, Mingo (1978) analyzed the effect of deposit-rate ceilings on bank risk. The analysis showed that deposit-rate ceilings increase a bank's total risk. The purpose of this note is to examine a different but related question: Is systematic risk affected by Regulation Q ceilings ceteris paribus? The results of our empirical test indicate that systematic risk is not affected by deposit-rate ceilings. Taken together then, Mingo's and the present results show that removal of deposit-rate ceilings would not increase bank risk.
... market efficiency has been challenged by behavioral finance, described in a recent New York T... more ... market efficiency has been challenged by behavioral finance, described in a recent New York Times article as the brand of economics that tries to explain the market in terms of the way humans behave both rationally and not.2 Professor Sendhil Mullainathan of Harvard ...
Purpose: This study assessed the performance of International Classification of Diseases 10th Rev... more Purpose: This study assessed the performance of International Classification of Diseases 10th Revision, Clinical Modification (ICD-10-CM) coronavirus disease 2019 (COVID-19) diagnostic code U07.1 against polymerase chain reaction (PCR) test results (Objective 1), and electronic medical record (EMR)-based codified algorithm for severe COVID-19 illness based on endpoints used in the Pfizer-BioNTech COVID-19 vaccine trial against chart review (Objective 2). Methods: This retrospective, longitudinal cohort study used EMR data from the Mass General Brigham COVID-19 Data Mart (3/1/2020-11/19/2020) for adult patients with ≥1 PCR test, antigen test, or code U07.1 (Objective 1) and adult patients with a positive PCR test hospitalized with COVID-19 (Objective 2). Results: Among 354,124 patients in Objective 1, 96% had ≥1 PCR test (including 6% with ≥1 positive PCR test; 11% with ≥1 code U07.1). Code U07.1 had low sensitivity (54%) and positive predictive value (PPV; 63%) but high specificity ...
Thesis. 1978. Ph.D.--Massachusetts Institute of Technology. Alfred P. Sloan School of Management.... more Thesis. 1978. Ph.D.--Massachusetts Institute of Technology. Alfred P. Sloan School of Management. MICROFICHE COPY AVAILABLE IN ARCHIVES AND DEWEY. Bibliography : leaf 226. Ph.D.
Partial deregulation has occurred in a broad range of industries, from telecommunications to tran... more Partial deregulation has occurred in a broad range of industries, from telecommunications to transportation to financial services.' This first phase of deregulation has given impetus to an intensive debate over future regulatory policy. Some commentators advocate further partial deregulation of industries such as natural gas and electric power2 while others push for re-regulation of airlines and railroads.' The immediate question is whether the deregulation that has taken place will achieve the benefits of market competition or will create instead imperfect markets that are neither fish nor fowl, markets that are less efficient than if they were either fully regulated or fully competitive. The question arises from the inherent nature of partial deregulation, which often maintains price controls and other restrictions on incumbent firms while removing entry barriers. This disparity may cause
The use of computers in health organizations raises questions as to the privacy and confidentiali... more The use of computers in health organizations raises questions as to the privacy and confidentiality of automated information. Results of several site visits are forwarded as a means for establishing the state of the art in medical information systems. The literature on the sub-ject, sparse as it is, is reviewed. Afiframework for analyzing the matter of data security is described. The major problem with medical data see-curity is taken to be the uncertainty surrounding the decision as to the required level and degree of security. In order to investigate the di-mensions of the problem several hypotheses are tested with the aid of a Security Attitude Survey which was administered to a sample of physicians and managers. The results of the questionnaire are analysed and lead to the fol-lowing conclusions. First, physicians, much more so than managers, perceive automated data as more susceptible than other data to either accidental or intentional disclosure, modification or destruction.
This study determined the risk of serious hepatotoxicity resulting in hospitalizations among pati... more This study determined the risk of serious hepatotoxicity resulting in hospitalizations among patients prescribed opioid/acetaminophen combinations. A retrospective cohort study using an insurance claims database was conducted. Adult patients with ≥1 claim for oxycodone/acetaminophen or hydrocodone/acetaminophen combinations were included (N = 1,228,356). A pre-post design was employed to compare serious hepatotoxicity risk before versus after initiation of opioid/acetaminophen combination. Serious hepatotoxicity risk between the opioid/acetaminophen group and a control group of opioid-alone users (N = 11,809) was also examined. Within the opioid/acetaminophen group, risk of hepatotoxicity-related hospitalizations pre- versus post-opioid/acetaminophen treatment was compared using the normal approximation with the binomial distribution. The incidence rate of hepatotoxicity-related hospitalizations for the opioid/acetaminophen group was compared with the opioid-alone group using multivariate Poisson regression adjusting for baseline differences between groups. Of the opioid/acetaminophen cohort, hepatotoxicity-related hospitalization risk in the 6-month post-opioid/acetaminophen period was lower than that in the pre-period with a risk reduction of 1.2 per 10,000 (pre-period = 0.12%; 95% confidence interval [CI], 0.12 to 0.13; post-period = 0.11%; 95% CI, 0.11 to 0.12). In the 12-month period, risk increased in the post-period by 2.4 per 10,000 (pre-period = 0.14%; 95% CI, 0.14 to 0.15; post-period = 0.17%; 95% CI, 0.16 to 0.18). After adjusting for confounders, the opioid-alone group did not demonstrate a lower rate of hepatotoxicity-related hospitalizations than the opioid/acetaminophen group (incidence rate ratio of opioid-alone over opioid/acetaminophen = 2.9; 95% CI, 1.8 to 4.7). There is no population data-based evidence supporting elevated risk of hepatotoxicity-related hospitalization associated with opioid/acetaminophen combinations.
ABSTRACT In a recent issue of this journal, Mingo (1978) analyzed the effect of deposit-rate ceil... more ABSTRACT In a recent issue of this journal, Mingo (1978) analyzed the effect of deposit-rate ceilings on bank risk. The analysis showed that deposit-rate ceilings increase a bank's total risk. The purpose of this note is to examine a different but related question: Is systematic risk affected by Regulation Q ceilings ceteris paribus? The results of our empirical test indicate that systematic risk is not affected by deposit-rate ceilings. Taken together then, Mingo's and the present results show that removal of deposit-rate ceilings would not increase bank risk.
... market efficiency has been challenged by behavioral finance, described in a recent New York T... more ... market efficiency has been challenged by behavioral finance, described in a recent New York Times article as the brand of economics that tries to explain the market in terms of the way humans behave both rationally and not.2 Professor Sendhil Mullainathan of Harvard ...
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