Papers by Beata Swiatkowska
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Jan 12, 2015
Background: Occupational exposures are known risk factors for lung cancer. Role of genetically de... more Background: Occupational exposures are known risk factors for lung cancer. Role of genetically determined host factors in occupational exposure-related lung cancer is unclear. Methods: We used genome-wide association (GWA) data from a case-control study conducted in six European countries from 1998-2002 to identify gene-occupation interactions and related pathways for lung cancer risk. GWA analysis was performed for each exposure using logistic regression and interaction term for genotypes and exposure was included in this model. Both SNP-based and gene-based interaction p-values were calculated. Pathway analysis was performed using three complementary methods and analyses were adjusted for multiple comparisons. We analyzed 312,605 SNPs and occupational exposure to 70 agents from 1802 lung cancer cases and 1725 cancer-free controls. Results: Mean age of study participants was 60.1±9.1 years and 75% were male. Largest number of significant associations (p-value ≤ 1 x 10-5) at SNP-lev...
Bookmarks Related papers MentionsView impact
Uploads
Papers by Beata Swiatkowska