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    Andrea Binks

    Following successful resuscitation from cardiac arrest, neurological impairment as well as other types of organ dysfunction still cause significant morbidity and mortality. The whole-body ischemia-reperfusion response that occurs during... more
    Following successful resuscitation from cardiac arrest, neurological impairment as well as other types of organ dysfunction still cause significant morbidity and mortality. The whole-body ischemia-reperfusion response that occurs during cardiac arrest and subsequent restoration of systemic circulation results in a series of pathophysiological processes that have been termed the post-cardiac arrest syndrome. The components of the post-cardiac arrest syndrome comprise post-cardiac arrest brain injury, post-cardiac arrest myocardial dysfunction, the systemic ischemia-reperfusion response and persistent precipitating pathology. Management of the post-cardiac arrest syndrome involves intensive care support with input from various other medical specialties in a coordinated fashion. Management of ventilation aims for normal carbon dioxide values and normoxia rather than hyperoxia. Management of the circulation commonly requires vasoactive support to overcome (often transient) myocardial dy...
    ABSTRACT Obesity is an increasing problem for anaesthetists, with the number of obese patients attending for both elective and emergency surgery expected to rise over the next four decades. Obesity itself causes physiological changes in... more
    ABSTRACT Obesity is an increasing problem for anaesthetists, with the number of obese patients attending for both elective and emergency surgery expected to rise over the next four decades. Obesity itself causes physiological changes in the cardiovascular, respiratory, gastrointestinal and endocrine systems, and obesity-related diseases often compound these. Anaesthesia in obese patients requires careful preoperative assessment to determine the effects of obesity and optimize any related diseases. Difficult bag/mask ventilation and securing of the airway is more common in the obese, so management plans should be in place to deal with the difficult airway. Careful attention should be paid to positioning obese patients on the operating table. Special equipment may be necessary to manage patients with weights in excess of 140 kg. Postoperative management of the obese patient should be aimed at optimizing respiratory function, maximizing effective analgesia, preventing venous thrombosis and early mobilization. High-dependency care may be necessary. There are pharmacological considerations in anaesthetizing the obese patient. Some drugs can be dosed according to total body weight, but many require calculation of an estimated lean body mass in order to avoid overdose. Obese patients present a particular challenge to the anaesthetist, which we are all likely to encounter more frequently in the future.