The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that have been damage... more The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that have been damaged by oxygen radicals, thus preventing lung cancer. Objective: This work is aiming to study the relationship between the variation in the blood levels of the 8-oxoguanine DNA glycosylase (OGG1), smoking and risk of lung cancer. Material and Methods: This study included 36 patients diagnosed as bronchogenic carcinoma, divided pathologically into 30 non small cell lung cancer (NSCLC) patients and 6 small cell lung cancer (SCLC) patients, 40 non-smoker and 40 smokers’ healthy subjects, taken as control. They were subjected to medical history taking, clinical examination, chest radiography and Quantitative RT- PCR of mRNA levels of OGG1 in blood. Results: There was a non significant increase in the mean level of the OGG1 in the non smoker group compared to the cancer and smokers’ groups (p>0.5). There was a non statistical significant decrease in the mean value of the OGG1 in the NSCLC compared to that of SCLC (p>0.5). There was statis-tical highly significant decrease in the mean value of the OGG1 in cases of adenocarcinoma compared to that in cases of squamous cell carcinoma and SCLC (p<0.0001). Conclusion: The decreased in the levels of OGG1 in blood could be a risk factor for lung cancer and was associated with adenocarcinoma. A substantial fraction of lung cancer cases might result from a combination of smoking and reduced OGG1 level. Key Words: OGG1 – RT PCT – Lung cancer.
Introduction: The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that ha... more Introduction: The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that have been damaged by oxygen radicals, thus preventing lung cancer. Objective: This work is aiming to study the relationship between the variation in the blood levels of the 8-oxoguanine DNA glycosylase (OGG1), smoking and risk of lung cancer. Material and Methods: This study included 36 patients diagnosed as bronchogenic carcinoma, divided pathologically into 30 non small cell lung cancer (NSCLC) patients and 6 small cell lung cancer (SCLC) patients, 40 non-smoker and 40 smokers’ healthy subjects, taken as control. They were subjected to medical history taking, clinical examination, chest radiography and Quantitative RT- PCR of mRNA levels of OGG1 in blood. Results: There was a non significant increase in the mean level of the OGG1 in the non smoker group compared to the cancer and smokers’ groups (p>0.5). There was a non statistical significant decrease in the mean value of the OGG1 in...
Introduction: The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that ha... more Introduction: The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that have been damaged by oxygen radicals, thus preventing lung cancer. Objective: This work is aiming to study the relationship between the variation in the blood levels of the 8-oxoguanine DNA glycosylase (OGG1), smoking and risk of lung cancer. Material and Methods: This study included 36 patients diagnosed as bronchogenic carcinoma, divided pathologically into 30 non small cell lung cancer (NSCLC) patients and 6 small cell lung cancer (SCLC) patients, 40 non-smoker and 40 smokers’ healthy subjects, taken as control. They were subjected to medical history taking, clinical examination, chest radiography and Quantitative RT- PCR of mRNA levels of OGG1 in blood. Results: There was a non significant increase in the mean level of the OGG1 in the non smoker group compared to the cancer and smokers’ groups (p>0.5). There was a non statistical significant decrease in the mean value of the OGG1 in...
Journal of the Egyptian National Cancer Institute, 2014
It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to a... more It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000-2008. Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s-80&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s period (p=0.038). Median sample size and study duration were almost stable through the three periods (p=0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design.
The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that have been damage... more The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that have been damaged by oxygen radicals, thus preventing lung cancer. Objective: This work is aiming to study the relationship between the variation in the blood levels of the 8-oxoguanine DNA glycosylase (OGG1), smoking and risk of lung cancer. Material and Methods: This study included 36 patients diagnosed as bronchogenic carcinoma, divided pathologically into 30 non small cell lung cancer (NSCLC) patients and 6 small cell lung cancer (SCLC) patients, 40 non-smoker and 40 smokers’ healthy subjects, taken as control. They were subjected to medical history taking, clinical examination, chest radiography and Quantitative RT- PCR of mRNA levels of OGG1 in blood. Results: There was a non significant increase in the mean level of the OGG1 in the non smoker group compared to the cancer and smokers’ groups (p>0.5). There was a non statistical significant decrease in the mean value of the OGG1 in the NSCLC compared to that of SCLC (p>0.5). There was statis-tical highly significant decrease in the mean value of the OGG1 in cases of adenocarcinoma compared to that in cases of squamous cell carcinoma and SCLC (p<0.0001). Conclusion: The decreased in the levels of OGG1 in blood could be a risk factor for lung cancer and was associated with adenocarcinoma. A substantial fraction of lung cancer cases might result from a combination of smoking and reduced OGG1 level. Key Words: OGG1 – RT PCT – Lung cancer.
Introduction: The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that ha... more Introduction: The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that have been damaged by oxygen radicals, thus preventing lung cancer. Objective: This work is aiming to study the relationship between the variation in the blood levels of the 8-oxoguanine DNA glycosylase (OGG1), smoking and risk of lung cancer. Material and Methods: This study included 36 patients diagnosed as bronchogenic carcinoma, divided pathologically into 30 non small cell lung cancer (NSCLC) patients and 6 small cell lung cancer (SCLC) patients, 40 non-smoker and 40 smokers’ healthy subjects, taken as control. They were subjected to medical history taking, clinical examination, chest radiography and Quantitative RT- PCR of mRNA levels of OGG1 in blood. Results: There was a non significant increase in the mean level of the OGG1 in the non smoker group compared to the cancer and smokers’ groups (p>0.5). There was a non statistical significant decrease in the mean value of the OGG1 in...
Introduction: The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that ha... more Introduction: The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that have been damaged by oxygen radicals, thus preventing lung cancer. Objective: This work is aiming to study the relationship between the variation in the blood levels of the 8-oxoguanine DNA glycosylase (OGG1), smoking and risk of lung cancer. Material and Methods: This study included 36 patients diagnosed as bronchogenic carcinoma, divided pathologically into 30 non small cell lung cancer (NSCLC) patients and 6 small cell lung cancer (SCLC) patients, 40 non-smoker and 40 smokers’ healthy subjects, taken as control. They were subjected to medical history taking, clinical examination, chest radiography and Quantitative RT- PCR of mRNA levels of OGG1 in blood. Results: There was a non significant increase in the mean level of the OGG1 in the non smoker group compared to the cancer and smokers’ groups (p>0.5). There was a non statistical significant decrease in the mean value of the OGG1 in...
Journal of the Egyptian National Cancer Institute, 2014
It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to a... more It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000-2008. Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s-80&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s period (p=0.038). Median sample size and study duration were almost stable through the three periods (p=0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design.
Uploads
Papers
Objective: This work is aiming to study the relationship between the variation in the blood levels of the 8-oxoguanine DNA glycosylase (OGG1), smoking and risk of lung cancer.
Material and Methods: This study included 36 patients diagnosed as bronchogenic carcinoma, divided pathologically into 30 non small cell lung cancer (NSCLC) patients and 6 small cell lung cancer (SCLC) patients, 40 non-smoker and 40 smokers’ healthy subjects, taken as control. They were subjected to medical history taking, clinical examination, chest radiography and Quantitative RT- PCR of mRNA levels of OGG1 in blood.
Results: There was a non significant increase in the mean level of the OGG1 in the non smoker group compared to the cancer and smokers’ groups (p>0.5). There was a non statistical significant decrease in the mean value of the OGG1 in the NSCLC compared to that of SCLC (p>0.5). There was statis-tical highly significant decrease in the mean value of the OGG1 in cases of adenocarcinoma compared to that in cases of squamous cell carcinoma and SCLC (p<0.0001).
Conclusion: The decreased in the levels of OGG1 in blood could be a risk factor for lung cancer and was associated with adenocarcinoma. A substantial fraction of lung cancer cases might result from a combination of smoking and reduced OGG1 level.
Key Words: OGG1 – RT PCT – Lung cancer.
Objective: This work is aiming to study the relationship between the variation in the blood levels of the 8-oxoguanine DNA glycosylase (OGG1), smoking and risk of lung cancer.
Material and Methods: This study included 36 patients diagnosed as bronchogenic carcinoma, divided pathologically into 30 non small cell lung cancer (NSCLC) patients and 6 small cell lung cancer (SCLC) patients, 40 non-smoker and 40 smokers’ healthy subjects, taken as control. They were subjected to medical history taking, clinical examination, chest radiography and Quantitative RT- PCR of mRNA levels of OGG1 in blood.
Results: There was a non significant increase in the mean level of the OGG1 in the non smoker group compared to the cancer and smokers’ groups (p>0.5). There was a non statistical significant decrease in the mean value of the OGG1 in the NSCLC compared to that of SCLC (p>0.5). There was statis-tical highly significant decrease in the mean value of the OGG1 in cases of adenocarcinoma compared to that in cases of squamous cell carcinoma and SCLC (p<0.0001).
Conclusion: The decreased in the levels of OGG1 in blood could be a risk factor for lung cancer and was associated with adenocarcinoma. A substantial fraction of lung cancer cases might result from a combination of smoking and reduced OGG1 level.
Key Words: OGG1 – RT PCT – Lung cancer.