e12052 Background: Previous important studies reported that breast conserving surgery (BCS) plus ... more e12052 Background: Previous important studies reported that breast conserving surgery (BCS) plus radiotherapy and modified radical mastectomy (MRM) were similar in breast cancer patients with tumor...
638 Background: In the present study, we investigate that which treatment choice is more effectiv... more 638 Background: In the present study, we investigate that which treatment choice is more effective in the human epidermal growth factor receptor 2 (HER2) positive breast cancer patients with brain metastases. Methods: Of 405 metastatic breast cancer patients with brain metastases at referral centers in Turkey, 111 patients treated with lapatinib or trastuzumab after brain metastases eligible for the analyses were identified. Patients received both drugs consecutively or sequentially were excluded from the study. Results: Median age was 44 years (27-76) and 46 of the 111 patients (41.5%) had received lapatinib. Median time to development of brain metastases was 12.2 months (0-71). Sixteen patients (14.4%) had undergone surgery, 33 (29.7%) radiosurgery, and 108 (97.2%) whole brain radiation therapy (WBRT). Median overall survival (OS) after brain metastases was 15 months(95% confidence interval (CI): 12.3-17.6). Lapatinib usage was prolonged OS over trastuzumab alone (19.1 months vs 12 months, p=0.039).Other parameters affecting the survival were Karnofsky performance score (KPS, >70), number of brain metastases (>3), extracranial metastases (≥2), performed neurosurgery, and received radiosurgery. After correction for potential confounders, lapatinib therapy remained an independent positive predictor for survival [Odds ratio (OR), 0.57; p=0.02). Conclusions: Although this retrospective multi-center study had several limitations, study results suggest that the usage of lapatinib after brain metastases prolonged survival compared to the usage of trastuzumab. This result should be support with prospective studies.
The surgeon today is obliged to operate on an increasing number of patients who are classified at... more The surgeon today is obliged to operate on an increasing number of patients who are classified at high risk. The hazards of blood splashes at operation have also been reported suggesting that Hepatitis B virus (HBV), Hepatitis C virus (HCV) and the Human Immunodeficiency Virus (HIV) can be transmitted by conjunctival contamination (1,2). The eye splash injuries due to peritoneal
Aim: Miliary tuberculosis (MTB) is a serious and rare form of tuberculosis. Studies comparatively... more Aim: Miliary tuberculosis (MTB) is a serious and rare form of tuberculosis. Studies comparatively reviewed children and adults with MTB are lacking. Methods: We retrospectively evaluated 56 pediatric and 26 adult MTB patients at a university hospital, between 1990 and 2003 Results: The median age at presentation was 3.5 years for children and 38 years for adults. Thirty- eight of
A 46-year-old man was diagnosed with brain metastasis after a two-year history of melanoma. Palia... more A 46-year-old man was diagnosed with brain metastasis after a two-year history of melanoma. Paliative radiotherapy was administered followed by dacarbazine, temozolamide, ipilimumab, stereotactic radiosurgery, ipilimumab reinduction and finally vemurafenib, to which the patient showed objective responses. The patient received vemurafenib for four months and died after progresive disease. Long-term follow-ups after surgery have been reported in the literature. However, in patients with unresectable metastases, outcomes are mostly detrimental. The present patient survived for 40 months after brain metastasis. The unusually long survival observed in the present case indicates the sequential effectiveness of radiotherapy, chemotherapy, ipilimumab, stereotactic radiosurgery and vemurafenib.
Abdominal tuberculosis (TB) is a rare manifestation, which can be overlooked on long-lasting and ... more Abdominal tuberculosis (TB) is a rare manifestation, which can be overlooked on long-lasting and non-specific findings unless a high index of suspicion is maintained. The purpose of the present study was to investigate the diagnostic features of 39 patients hospitalized with tuberculous peritonitis (TBP) in Dicle University Hospital, Turkey between January 1994 and August 2003. Twenty-two patients were male; patient age ranged between 1 and 59 years (mean: 16.2 +/- 14.4 years). There were 21 patients (54%) under 15 years of age. Thirteen children had a history of familial TB and seven adults had prior history of TB. Six (29%) of 21 pediatric cases had bacille Calmette-Guerin (BCG) scars and results of 5-tuberculin units (TU) tuberculin test were positive in seven children (18%). Of all cases, the most common presenting findings were abdominal pain (95%), ascites (92%) and abdominal distention (82%). Five of the patients had accompanying pulmonary TB, and six patients (15%) had intestinal TB who were admitted to emergency service with acute abdomen, of whom three (8%) had perforation and three (8%) had ileus. Histopathologically 20 cases (51%) were proven on abdominal ultrasonography, and computed tomography revealed most commonly ascites and thickening of peritoneum. No microbiologic evidence was obtained except three positive culture results for Mycobacterium tuberculosis. As a result, TBP should be considered for diagnosis, in patients with non-specific symptoms of abdominal pain, wasting, fever, loss of appetite, abdominal distension and even symptoms of acute abdomen, because early diagnosis and effective treatment will decrease morbidity and mortality.
The purpose of this study was to determine whether the presence of diabetes mellitus (DM) influen... more The purpose of this study was to determine whether the presence of diabetes mellitus (DM) influences the incidence and severity of peripheral sensory neuropathy (PSN) in patients using taxane therapy. A retrospective single-center analysis was conducted: Patients with PSN at baseline were excluded. The incidence of PSN was evaluated retrospectively in patient subgroups who received taxane arm and taxane-plus-platinum-agents combination arm with or without known DM at baseline. Three hundred seventy-four patients were enrolled in this study, 81 (21.6 %) of patients had DM at baseline. The incidence of grade 1 PSN (non-DM/DM) in patients receiving taxane-based chemotherapy was 33.4/25.9 % and more than grade 2 PSN (non-DM/DM) was 15/34.6 %. The rate of neuropathy of non-diabetic patients was 48.8 %, while the rate of diabetic patients was 52.8 and 75 % in DM duration below 5 years and above 5 years group, respectively. This retrospective analysis indicates that taxane-based therapy in DM patients whose disease duration is above 5 years appears to affect the incidence and severity of PSN without known baseline neuropathy. The probability of PSN with taxane-based therapy was similar in DM duration below 5 years and non-DM patients.
MikroRNAlar (miRNAlar) yaklaşık 22 nükleotit uzunluğunda kodlanmayan RNA molekülleridir ve yapıla... more MikroRNAlar (miRNAlar) yaklaşık 22 nükleotit uzunluğunda kodlanmayan RNA molekülleridir ve yapılan çalışmalarda en az genlerin yaklaşık % 30’unu düzenlediği düşünülmektedir. MiRNA’ların düzensiz ifadelenmesi düzenlemiş olduğu yolaklarda ciddi problemlere ve hastalıklara sebep olmaktadır. Kanserde özellikle bazı yolaklardaki miRNA’lar önem arz etmektedir örnek olarak hücre çoğalması, hücre döngüsü, hücre ölümü verilebilir. Apoptozis (programlı hücre ölümü I) yolağının; kanserli hücrelerde sorunlu olması kanserin gelişiminde ve ilerlemesinde ana sebeplerden biridir. Bundan dolayı apoptosiz yolağındaki genler ve onların düzenlenmesi ve yakın zamanda apoptosiz ile ilişkili miRNA’lar sıklıkla çalışılmaktadır. MiRNA’ların günümüzde kanserde biyobelirteç olarak ve gen terapide kullanılabileceği düşünülmektedir. Meme kanseri kadınlarda en fazla görülen kanser tipi olup, dünyada bütün kanserlerin yaklaşık %30’unu teşkil etmektedir. Meme kanseri bu kadar sık görülmesine rağmen sağ kalımı birç...
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
In lymph node-negative, hormone-positive, and Her2-negative breast cancer patients, the benefits ... more In lymph node-negative, hormone-positive, and Her2-negative breast cancer patients, the benefits of adding adjuvant chemotherapy to hormonal therapy continue to be debated, especially for low to intermediate grade and small tumors. Excluding patients with T4 disease, we retrospectively reviewed the records of patients with long-term follow-up at our center between 2003 and 2014. Among node-negative, hormone-positive and HER2-negative breast cancer patients, we compared two groups of patients: those given both chemotherapy (doxorubicin+cyclophosphamide) and hormonotherapy, and those prescribed hormonotherapy alone. The primary endpoints were progression-free (PFS) and overall survival (OS). Overall, no difference was observed between these two treatment groups in either DFS or OS. However, for both outcomes, there was a trend towards improved DFS and OS favoring the hormone-only group. In selected subgroups of breast cancer patients, administering adjuvant hormonal therapy alone seem...
Cancer is a prothrombotic state and anticancer therapies are often complicated by vascular events... more Cancer is a prothrombotic state and anticancer therapies are often complicated by vascular events. The risk of developing thromboembolic events is substantially increased in patients with pancreatic cancer. One possible presentation of vascular events in pancreatic cancer is disseminated intravascular coagulation (DIC). In our case a patient with a diagnosis of pancreatic cancer initially presented with thrombosis and received low molecular weight heparin (LMWH) in addition to standard chemotherapy regimen. He was thought to have DIC by assessment of clinical and laboratory findings. Clinically, thrombosis was first located in the left femoral vein and encountered at right femoral artery after three weeks. This pattern was an unusual presentation of DIC. Subclinical DIC is common in patients presenting with pancreatic cancer and is considered a 'poor' prognostic factor. Acute DIC, on the other hand is a potentially mortal condition.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
To compare the effectiveness of adjuvant chemotherapy regimens in triple negative breast cancer (... more To compare the effectiveness of adjuvant chemotherapy regimens in triple negative breast cancer (TNBC) for which no protocol has been determined to be treatment of choice. In this single-center retrospective trial, we analyzed the adjuvant regimens of 164 TNBC patients among 3253 breast cancer patient records. Adjuvant TAC (docetaxel, doxorubicin, cyclophosphamide), CAF (cyclophosphamide, doxorubicin, 5fluorouracil), and AC-T (doxorubicin, cyclophosphamide followed by docetaxel) regimens were compared in terms of disease free survival (DFS) and overall survival (OS). In terms of both DFS and OS TAC was significantly superior to AC-T in node positive TNBC. When node negative and positive patients were analyzed together, TAC was still significantly superior to AC-T in terms of DFS and OS. There was a trend favoring CAF over AC-T, however, it was only significant in terms of OS when all node negative and positive TNBC patients were incorporated together. In the adjuvant setting, especi...
Several studies have now demonstrated that the lymph node ratio (LNR), as a superior indicator of... more Several studies have now demonstrated that the lymph node ratio (LNR), as a superior indicator of axillary tumor burden to the number of excised nodes. While, about the prognostic value of LNR on the the survival of elderly patients is limited. The aim of this retrospective multicenter study is to evaluate the prognostic value of lymph node ratio in elderly patients with node positive breast cancer. Onehundredeightyfour patient with operable breast cancer, recruited from 17 institutions, were enrolled into the retrospectively study. Eleven potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival. Among the eleven variables of univariate analysis, four variables were identified to have prognostic significance for Overall survival (OS): pathologic tumor size (T), No. of positive nodes (N), LNR and estrogen receptor-positive (ER). Among the eleven variables of univa...
Sunitinib is a multi-targeted thyrosine kinase receptor inhibitor used in patients with advanced ... more Sunitinib is a multi-targeted thyrosine kinase receptor inhibitor used in patients with advanced gastrointestinal stromal tumours (GISTs). We evaluated the efficacy and tolerability of sunitinib therapy in Turkish patients with GISTs. Between January 2001 and April 2012, 57 patients who had progressive disease or experienced unacceptable toxicity during imatinib treatment from multiple centers were investigated retrospectively. Thirty-three patients were male and 24 were female. The median age was 55 years (range; 16-84 years). Thirty-eight of the patients received imatinib for longer than 12 months, 13 patients received for 6-12 months, and 6 patients received for less than six months. The clinical benefit of sunitinib was 73.7%. Treatment-related adverse events were reported in 78% of the patients. Adverse events were generally mild to moderate in intensity. The median progression free survival (PFS) and overall survival (OS) of the patients that received sunitinib were 10.8 month...
... Celaletdin Camcı1, Mehmet Emin Kalender1, Semra Paydaş2, Alper Sevinç1, Suzan Zorludemir3,Ali... more ... Celaletdin Camcı1, Mehmet Emin Kalender1, Semra Paydaş2, Alper Sevinç1, Suzan Zorludemir3,Ali Suner1 ... Cancer 1983;51(8):1333-8. 5. Sauer T, Furu I, Beraki K, Jebsen PW, Ormerod E, Naess O. nm23 protein expression in fine needle aspirates from breast carcinoma ...
Vemurafenib is an inhibitor of the BRAF V600E mutation which is associated with tumor responses i... more Vemurafenib is an inhibitor of the BRAF V600E mutation which is associated with tumor responses in patients with metastatic melanoma. Although it is generally well tolerated, common side effects of vemurafenib have been reported. Arthralgia is one of the more common adverse event associated with vemurafenib. We herein report a 49-year-old woman diagnosed with metastatic melanoma harboring the BRAF V600E mutation with severe polyarthritis associated with vemurafenib after 7 days of treatment. Sonographic examination of affected joints revealed synovitis and the patient's articular symptoms were improved by analgesic and anti-inflammatory treatment, including corticosteroids. During therapy with selective BRAF inhibitors, arthritis represents a new adverse event that can require dose reduction. In case of this adverse event, treatment with anti-inflammatory drugs, such as ibuprofen and prednisone, should be initiated early to keep patients on treatment and to avoid drug discontinuation and tumor progression.
e12052 Background: Previous important studies reported that breast conserving surgery (BCS) plus ... more e12052 Background: Previous important studies reported that breast conserving surgery (BCS) plus radiotherapy and modified radical mastectomy (MRM) were similar in breast cancer patients with tumor...
638 Background: In the present study, we investigate that which treatment choice is more effectiv... more 638 Background: In the present study, we investigate that which treatment choice is more effective in the human epidermal growth factor receptor 2 (HER2) positive breast cancer patients with brain metastases. Methods: Of 405 metastatic breast cancer patients with brain metastases at referral centers in Turkey, 111 patients treated with lapatinib or trastuzumab after brain metastases eligible for the analyses were identified. Patients received both drugs consecutively or sequentially were excluded from the study. Results: Median age was 44 years (27-76) and 46 of the 111 patients (41.5%) had received lapatinib. Median time to development of brain metastases was 12.2 months (0-71). Sixteen patients (14.4%) had undergone surgery, 33 (29.7%) radiosurgery, and 108 (97.2%) whole brain radiation therapy (WBRT). Median overall survival (OS) after brain metastases was 15 months(95% confidence interval (CI): 12.3-17.6). Lapatinib usage was prolonged OS over trastuzumab alone (19.1 months vs 12 months, p=0.039).Other parameters affecting the survival were Karnofsky performance score (KPS, >70), number of brain metastases (>3), extracranial metastases (≥2), performed neurosurgery, and received radiosurgery. After correction for potential confounders, lapatinib therapy remained an independent positive predictor for survival [Odds ratio (OR), 0.57; p=0.02). Conclusions: Although this retrospective multi-center study had several limitations, study results suggest that the usage of lapatinib after brain metastases prolonged survival compared to the usage of trastuzumab. This result should be support with prospective studies.
The surgeon today is obliged to operate on an increasing number of patients who are classified at... more The surgeon today is obliged to operate on an increasing number of patients who are classified at high risk. The hazards of blood splashes at operation have also been reported suggesting that Hepatitis B virus (HBV), Hepatitis C virus (HCV) and the Human Immunodeficiency Virus (HIV) can be transmitted by conjunctival contamination (1,2). The eye splash injuries due to peritoneal
Aim: Miliary tuberculosis (MTB) is a serious and rare form of tuberculosis. Studies comparatively... more Aim: Miliary tuberculosis (MTB) is a serious and rare form of tuberculosis. Studies comparatively reviewed children and adults with MTB are lacking. Methods: We retrospectively evaluated 56 pediatric and 26 adult MTB patients at a university hospital, between 1990 and 2003 Results: The median age at presentation was 3.5 years for children and 38 years for adults. Thirty- eight of
A 46-year-old man was diagnosed with brain metastasis after a two-year history of melanoma. Palia... more A 46-year-old man was diagnosed with brain metastasis after a two-year history of melanoma. Paliative radiotherapy was administered followed by dacarbazine, temozolamide, ipilimumab, stereotactic radiosurgery, ipilimumab reinduction and finally vemurafenib, to which the patient showed objective responses. The patient received vemurafenib for four months and died after progresive disease. Long-term follow-ups after surgery have been reported in the literature. However, in patients with unresectable metastases, outcomes are mostly detrimental. The present patient survived for 40 months after brain metastasis. The unusually long survival observed in the present case indicates the sequential effectiveness of radiotherapy, chemotherapy, ipilimumab, stereotactic radiosurgery and vemurafenib.
Abdominal tuberculosis (TB) is a rare manifestation, which can be overlooked on long-lasting and ... more Abdominal tuberculosis (TB) is a rare manifestation, which can be overlooked on long-lasting and non-specific findings unless a high index of suspicion is maintained. The purpose of the present study was to investigate the diagnostic features of 39 patients hospitalized with tuberculous peritonitis (TBP) in Dicle University Hospital, Turkey between January 1994 and August 2003. Twenty-two patients were male; patient age ranged between 1 and 59 years (mean: 16.2 +/- 14.4 years). There were 21 patients (54%) under 15 years of age. Thirteen children had a history of familial TB and seven adults had prior history of TB. Six (29%) of 21 pediatric cases had bacille Calmette-Guerin (BCG) scars and results of 5-tuberculin units (TU) tuberculin test were positive in seven children (18%). Of all cases, the most common presenting findings were abdominal pain (95%), ascites (92%) and abdominal distention (82%). Five of the patients had accompanying pulmonary TB, and six patients (15%) had intestinal TB who were admitted to emergency service with acute abdomen, of whom three (8%) had perforation and three (8%) had ileus. Histopathologically 20 cases (51%) were proven on abdominal ultrasonography, and computed tomography revealed most commonly ascites and thickening of peritoneum. No microbiologic evidence was obtained except three positive culture results for Mycobacterium tuberculosis. As a result, TBP should be considered for diagnosis, in patients with non-specific symptoms of abdominal pain, wasting, fever, loss of appetite, abdominal distension and even symptoms of acute abdomen, because early diagnosis and effective treatment will decrease morbidity and mortality.
The purpose of this study was to determine whether the presence of diabetes mellitus (DM) influen... more The purpose of this study was to determine whether the presence of diabetes mellitus (DM) influences the incidence and severity of peripheral sensory neuropathy (PSN) in patients using taxane therapy. A retrospective single-center analysis was conducted: Patients with PSN at baseline were excluded. The incidence of PSN was evaluated retrospectively in patient subgroups who received taxane arm and taxane-plus-platinum-agents combination arm with or without known DM at baseline. Three hundred seventy-four patients were enrolled in this study, 81 (21.6 %) of patients had DM at baseline. The incidence of grade 1 PSN (non-DM/DM) in patients receiving taxane-based chemotherapy was 33.4/25.9 % and more than grade 2 PSN (non-DM/DM) was 15/34.6 %. The rate of neuropathy of non-diabetic patients was 48.8 %, while the rate of diabetic patients was 52.8 and 75 % in DM duration below 5 years and above 5 years group, respectively. This retrospective analysis indicates that taxane-based therapy in DM patients whose disease duration is above 5 years appears to affect the incidence and severity of PSN without known baseline neuropathy. The probability of PSN with taxane-based therapy was similar in DM duration below 5 years and non-DM patients.
MikroRNAlar (miRNAlar) yaklaşık 22 nükleotit uzunluğunda kodlanmayan RNA molekülleridir ve yapıla... more MikroRNAlar (miRNAlar) yaklaşık 22 nükleotit uzunluğunda kodlanmayan RNA molekülleridir ve yapılan çalışmalarda en az genlerin yaklaşık % 30’unu düzenlediği düşünülmektedir. MiRNA’ların düzensiz ifadelenmesi düzenlemiş olduğu yolaklarda ciddi problemlere ve hastalıklara sebep olmaktadır. Kanserde özellikle bazı yolaklardaki miRNA’lar önem arz etmektedir örnek olarak hücre çoğalması, hücre döngüsü, hücre ölümü verilebilir. Apoptozis (programlı hücre ölümü I) yolağının; kanserli hücrelerde sorunlu olması kanserin gelişiminde ve ilerlemesinde ana sebeplerden biridir. Bundan dolayı apoptosiz yolağındaki genler ve onların düzenlenmesi ve yakın zamanda apoptosiz ile ilişkili miRNA’lar sıklıkla çalışılmaktadır. MiRNA’ların günümüzde kanserde biyobelirteç olarak ve gen terapide kullanılabileceği düşünülmektedir. Meme kanseri kadınlarda en fazla görülen kanser tipi olup, dünyada bütün kanserlerin yaklaşık %30’unu teşkil etmektedir. Meme kanseri bu kadar sık görülmesine rağmen sağ kalımı birç...
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
In lymph node-negative, hormone-positive, and Her2-negative breast cancer patients, the benefits ... more In lymph node-negative, hormone-positive, and Her2-negative breast cancer patients, the benefits of adding adjuvant chemotherapy to hormonal therapy continue to be debated, especially for low to intermediate grade and small tumors. Excluding patients with T4 disease, we retrospectively reviewed the records of patients with long-term follow-up at our center between 2003 and 2014. Among node-negative, hormone-positive and HER2-negative breast cancer patients, we compared two groups of patients: those given both chemotherapy (doxorubicin+cyclophosphamide) and hormonotherapy, and those prescribed hormonotherapy alone. The primary endpoints were progression-free (PFS) and overall survival (OS). Overall, no difference was observed between these two treatment groups in either DFS or OS. However, for both outcomes, there was a trend towards improved DFS and OS favoring the hormone-only group. In selected subgroups of breast cancer patients, administering adjuvant hormonal therapy alone seem...
Cancer is a prothrombotic state and anticancer therapies are often complicated by vascular events... more Cancer is a prothrombotic state and anticancer therapies are often complicated by vascular events. The risk of developing thromboembolic events is substantially increased in patients with pancreatic cancer. One possible presentation of vascular events in pancreatic cancer is disseminated intravascular coagulation (DIC). In our case a patient with a diagnosis of pancreatic cancer initially presented with thrombosis and received low molecular weight heparin (LMWH) in addition to standard chemotherapy regimen. He was thought to have DIC by assessment of clinical and laboratory findings. Clinically, thrombosis was first located in the left femoral vein and encountered at right femoral artery after three weeks. This pattern was an unusual presentation of DIC. Subclinical DIC is common in patients presenting with pancreatic cancer and is considered a 'poor' prognostic factor. Acute DIC, on the other hand is a potentially mortal condition.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
To compare the effectiveness of adjuvant chemotherapy regimens in triple negative breast cancer (... more To compare the effectiveness of adjuvant chemotherapy regimens in triple negative breast cancer (TNBC) for which no protocol has been determined to be treatment of choice. In this single-center retrospective trial, we analyzed the adjuvant regimens of 164 TNBC patients among 3253 breast cancer patient records. Adjuvant TAC (docetaxel, doxorubicin, cyclophosphamide), CAF (cyclophosphamide, doxorubicin, 5fluorouracil), and AC-T (doxorubicin, cyclophosphamide followed by docetaxel) regimens were compared in terms of disease free survival (DFS) and overall survival (OS). In terms of both DFS and OS TAC was significantly superior to AC-T in node positive TNBC. When node negative and positive patients were analyzed together, TAC was still significantly superior to AC-T in terms of DFS and OS. There was a trend favoring CAF over AC-T, however, it was only significant in terms of OS when all node negative and positive TNBC patients were incorporated together. In the adjuvant setting, especi...
Several studies have now demonstrated that the lymph node ratio (LNR), as a superior indicator of... more Several studies have now demonstrated that the lymph node ratio (LNR), as a superior indicator of axillary tumor burden to the number of excised nodes. While, about the prognostic value of LNR on the the survival of elderly patients is limited. The aim of this retrospective multicenter study is to evaluate the prognostic value of lymph node ratio in elderly patients with node positive breast cancer. Onehundredeightyfour patient with operable breast cancer, recruited from 17 institutions, were enrolled into the retrospectively study. Eleven potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival. Among the eleven variables of univariate analysis, four variables were identified to have prognostic significance for Overall survival (OS): pathologic tumor size (T), No. of positive nodes (N), LNR and estrogen receptor-positive (ER). Among the eleven variables of univa...
Sunitinib is a multi-targeted thyrosine kinase receptor inhibitor used in patients with advanced ... more Sunitinib is a multi-targeted thyrosine kinase receptor inhibitor used in patients with advanced gastrointestinal stromal tumours (GISTs). We evaluated the efficacy and tolerability of sunitinib therapy in Turkish patients with GISTs. Between January 2001 and April 2012, 57 patients who had progressive disease or experienced unacceptable toxicity during imatinib treatment from multiple centers were investigated retrospectively. Thirty-three patients were male and 24 were female. The median age was 55 years (range; 16-84 years). Thirty-eight of the patients received imatinib for longer than 12 months, 13 patients received for 6-12 months, and 6 patients received for less than six months. The clinical benefit of sunitinib was 73.7%. Treatment-related adverse events were reported in 78% of the patients. Adverse events were generally mild to moderate in intensity. The median progression free survival (PFS) and overall survival (OS) of the patients that received sunitinib were 10.8 month...
... Celaletdin Camcı1, Mehmet Emin Kalender1, Semra Paydaş2, Alper Sevinç1, Suzan Zorludemir3,Ali... more ... Celaletdin Camcı1, Mehmet Emin Kalender1, Semra Paydaş2, Alper Sevinç1, Suzan Zorludemir3,Ali Suner1 ... Cancer 1983;51(8):1333-8. 5. Sauer T, Furu I, Beraki K, Jebsen PW, Ormerod E, Naess O. nm23 protein expression in fine needle aspirates from breast carcinoma ...
Vemurafenib is an inhibitor of the BRAF V600E mutation which is associated with tumor responses i... more Vemurafenib is an inhibitor of the BRAF V600E mutation which is associated with tumor responses in patients with metastatic melanoma. Although it is generally well tolerated, common side effects of vemurafenib have been reported. Arthralgia is one of the more common adverse event associated with vemurafenib. We herein report a 49-year-old woman diagnosed with metastatic melanoma harboring the BRAF V600E mutation with severe polyarthritis associated with vemurafenib after 7 days of treatment. Sonographic examination of affected joints revealed synovitis and the patient's articular symptoms were improved by analgesic and anti-inflammatory treatment, including corticosteroids. During therapy with selective BRAF inhibitors, arthritis represents a new adverse event that can require dose reduction. In case of this adverse event, treatment with anti-inflammatory drugs, such as ibuprofen and prednisone, should be initiated early to keep patients on treatment and to avoid drug discontinuation and tumor progression.
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