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Research Interests: Medicine and Gynecology
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OBJECTIVE: Scientific BACKGROUND: Post-dural puncture headache (PDPH) is a common complication (30%-40%) of diagnostic lumbar puncture (LP). There are several reports concerning the pharmacologic treatments of PDPH. It has been reported... more
OBJECTIVE: Scientific BACKGROUND: Post-dural puncture headache (PDPH) is a common complication (30%-40%) of diagnostic lumbar puncture (LP). There are several reports concerning the pharmacologic treatments of PDPH. It has been reported that peroral theophylline is effective in pharmacological management of PDPH. There are few reports about this modality. PDPH commonly presents with nausea and vomiting and these limit the peroral medications. It will be useful to use parenteral medications for rapid and effective treatments. IV theophylline treatment in post-punctural headache might be useful. METHODS: Cases: A total of five cases presented with PDPHs which were defined according to the International Classification of Headache Disorders Criteria, which did not respond to other pharmacological treatments were presented in this paper. All of the cases had a significant relief of pain after IV theophylline infusion. RESULTS: CONCLUSION: CONCLUSION: To the best of our knowledge, theophylline infusion for PDPH which does not respond to other treatments is a new method and it seems to be clinically useful
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Research Interests: Treatment, Medicine, Symptoms, Etiology, Risk factors, and 3 moreTedavi, Risk Factors, and Venous Thrombosis
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Purpose: Intracranial lipomas are rare congenital malformations. The most common location of intracranial lipoma is the midline cerebral structures. The most frequently seen symptoms are headaches, seizures, psychomotor retardation and... more
Purpose: Intracranial lipomas are rare congenital malformations. The most common location of intracranial lipoma is the midline cerebral structures. The most frequently seen symptoms are headaches, seizures, psychomotor retardation and cranial nerve deficits. This study aimed to evaluate the clinical and radiological findings of 14 patients with intracranial lipoma. Materials and methods: The study comprised 14 patients diagnosed with intracranial lipoma from computed tomography and magnetic resonance imaging taken after presentation at our hospital with headaches or seizures between January 2008 and April 2012. The cranial CT and MR images were evaluated by two experienced specialist radiologists. The lipoma localisation, size, morphology, any concomitant anomalies and findings of compression were recorded. Results: The study comprised 14 patients diagnosed with intracranial lipoma. The lipoma was observed to be located pericallosal, adjacent to the mamillary body and the optic chiasm, interhemispheric, in the quadrigeminal cistern and sylvian fissure. 3 patients had a history of seizures. The others had headaches. Conclusions: If there are no concomitant central nervous system (CNS) anomalies, there are no significant clinical or neurological findings apart from headaches.
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... Sebahat Canpolat GÜL 1 , Özlem COŞKUN 2 , Tuğba TUNÇ 2 , Özcan KOCATÜRK 2 , Serap ÜÇLER 2 , Levent İNAN 2. ... 3) Kumral E, Özkaya B, Sağduyu A, Sirin H, Vardarlı E, PehlivanM.The Ege Stroke Registry: a hospital-based study in the... more
... Sebahat Canpolat GÜL 1 , Özlem COŞKUN 2 , Tuğba TUNÇ 2 , Özcan KOCATÜRK 2 , Serap ÜÇLER 2 , Levent İNAN 2. ... 3) Kumral E, Özkaya B, Sağduyu A, Sirin H, Vardarlı E, PehlivanM.The Ege Stroke Registry: a hospital-based study in the Aegean Region, İzmir, Turkey ...
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Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing/short-lasting unilateral neuralgiform headache with cranial autonomic features (SUNCT/SUNA) is a rare severe headache. At the time of an attack, it can... more
Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing/short-lasting unilateral neuralgiform headache with cranial autonomic features (SUNCT/SUNA) is a rare severe headache. At the time of an attack, it can hinder a patient from eating and requires acute intervention. The sphenopalatine ganglion is an extracranial parasympathetic ganglion with both sensory and autonomic fibers. Sphenopalatine ganglion block has long been used in the treatment of headache, particularly when conventional methods have failed. Here, we present a patient who was resistant to intravenous lidocaine, but responded rapidly to sphenopalatine ganglion block during an acute episode of SUNCT/SUNA.
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BACKGROUND AND AIMS Carotid artery stenting (CAS) is an accepted treatment modality for carotid artery disease. However, CAS is associated with periprocedural embolic events, and the effect of balloon post-dilatation has not been... more
BACKGROUND AND AIMS Carotid artery stenting (CAS) is an accepted treatment modality for carotid artery disease. However, CAS is associated with periprocedural embolic events, and the effect of balloon post-dilatation has not been sufficiently investigated in large studies. We assessed the effect of post-dilatation on periprocedural outcomes during CAS. METHODS The study included 128 patients who underwent CAS. The patients were divided into groups according to whether post-dilatation was (post-dilatation [+], group 1) or was not (post dilatation [-], group 2) performed after stent deployment. Major adverse events were defined as death, minor or major stroke, and transient ischemic attack at 30 days. Silent ischemia was assessed using diffusion-weighted magnetic resonance imaging. RESULTS No significant between-group differences were found in baseline characteristics, comorbid diseases, or lesion characteristics. The degree of stenosis and procedure duration was greater in group 1 than in group 2. The rate of major adverse events at 30 days was similar between the two groups (5.1% vs. 4.3%, p = 0.844). The silent ischemia rate and number of high-intensity signals were higher in group 1 than in group 2 (45.8% vs. 26.1%, p = 0.020 and 1.01 [1.2] vs. 0.42 [0.79], p = 0.002). Multivariate analysis revealed that post-dilatation was associated with a 2.4-fold increase in silent ischemia (95% confidence interval: 1.15-5.20, p = 0.020). CONCLUSIONS Although post-dilatation was not associated with an increase in major adverse events, it significantly increased the incidence of periprocedural silent ischemia. Therefore, post-dilation should be performed only in cases with severe residual stenosis after CAS.
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Research Interests: Medicine and Fat Embolism
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Research Interests: Medicine and Gynecology
Amac: Bu calismada, posterior sirkulasyon infarkti (POCI) olan hastalarin demografik ozellikleri, risk faktorleri, etiyolojik ve klinik profilleri gozden gecirerek bu parametreler bakimindan cinsiyetler arasinda farklilik olup olmadigini... more
Amac: Bu calismada, posterior sirkulasyon infarkti (POCI) olan hastalarin demografik ozellikleri, risk faktorleri, etiyolojik ve klinik profilleri gozden gecirerek bu parametreler bakimindan cinsiyetler arasinda farklilik olup olmadigini degerlendirmeyi amacladik. Materyal ve Metod: Bu calismaya Baskent Universitesi Adana Arastirma ve Uygulama Hastanesi, Kahramanmaras Ozel Hayat Hastanesi ve Şanliurfa Mehmet Akif Inan Egitim Arastirma Hastanesine 2014 yili ilk 6 aylik sure icerisinde basvuran ve posterior sirkulasyon infarktlari olan ardisik 11'i (% 26.2) kadin ve 31'i (%73.8) erkek toplam 42 hasta dahil edildi. Yas, egitim durumu, risk faktoleri, inme etiyolojisi ve olum orani bakimindan kadin ve erkek hastalar karsilastirildi. Bulgular: Kadin hastalarda erkek hastalara gore; gecici iskemik atak, mortalite orani daha yuksek saptandi. Risk faktorlerinden koroner arter hastaligi, konjestif kalp yetmezligi, atrial fibrilasyon, hiperlipidemi, diabetes mellitus, hiperlipidemi varligi daha yuksek oranda saptandi. Sonuc: Calismamizdaki bulgular, POCI sendromlu hastalarda cinsiyetin kadin olmasinin inmenin klinik seyrini olumsuz yonde etkileyebilecegini dusundurmektedir.
Research Interests: Medicine and Gynecology
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1 Yusuf İnanç1, Halil Ay2, Yılmaz İnanç3, Zülfikar Arlıer1, Özcan Kocatürk4, Mehtap Kocatürk4, Semih Giray1, Suat Kamışlı5 1Başkent Üniversitesi Adana Uygulama ve Arastırma Hastanesi, Tıp Fakültesi, Nöroloji, Adana, 2Şanlıurfa Özel Ursu... more
1 Yusuf İnanç1, Halil Ay2, Yılmaz İnanç3, Zülfikar Arlıer1, Özcan Kocatürk4, Mehtap Kocatürk4, Semih Giray1, Suat Kamışlı5 1Başkent Üniversitesi Adana Uygulama ve Arastırma Hastanesi, Tıp Fakültesi, Nöroloji, Adana, 2Şanlıurfa Özel Ursu Hastanesi, Nöroloji Kliniği, Şanlıurfa, 3Kahramanmaraş Özel Hayat Hastanesi, Nöroloji Kliniği, Kahramanmaraş, 4Harran Üniversitesi, Tıp Fakültesi, Nöroloji, Şanlıurfa, 5Turgut Özal Tıp Merkezi, Nöroloji, Malatya, Türkiye Şanlıurfa İlinde İnme / Strokes in Sanliurfa Demographic Characteristics of Strokes Types in Sanliurfa
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Objectives: Upper air obstruction leads hypoxia, it is also known that S-100B levels increase by glial activations indicate cerebral hypoxic injury. This study aimed to evaluate the preoperative and postoperative S-100B levels in children... more
Objectives: Upper air obstruction leads hypoxia, it is also known that S-100B levels increase by glial activations indicate cerebral hypoxic injury. This study aimed to evaluate the preoperative and postoperative S-100B levels in children with chronic adenotonsillar hypertrophy. Patients and methods: The study comprised 40 patients with indications for tonsillectomy and/or adenoidectomy following a diagnosis of chronic adenotonsillar hypertrophy and 40 age-gender matched control patients. Blood samples were taken from the patients preoperatively and at four weeks postoperatively. Preoperative and postoperative serum S-100B levels were analyzed. Results: The serum S-100B levels in the preoperative period were found to be significantly higher compared to those of the control group (p < 0.05). The S-100B levels were significantly decreased in the postoperative period (p < 0.05). Conclusions: The development of chronic adenotonsillar hypertrophy would play a role in increased S-100B levels. This indicates that neuronal damage would exists in patients with chronic adenotonsillar hypertrophy.
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Stroke remains one of the leading causes of death and disability in Europe. The European Stroke Action Plan (ESAP) defines four main targets for the years 2018 to 2030. The COVID-19 pandemic forced the use of innovative technologies and... more
Stroke remains one of the leading causes of death and disability in Europe. The European Stroke Action Plan (ESAP) defines four main targets for the years 2018 to 2030. The COVID-19 pandemic forced the use of innovative technologies and created pressure to improve internet networks. Moreover, 5G internet network will be helpful for the transfer and collecting of extremely big databases. Nowadays, the speed of internet connection is a limiting factor for robotic systems, which can be controlled and commanded potentially from various places in the world. Innovative technologies can be implemented for acute stroke patient management soon. Artificial intelligence (AI) and robotics are used increasingly often without the exception of medicine. Their implementation can be achieved in every level of stroke care. In this article, all steps of stroke health care processes are discussed in terms of how to improve them (including prehospital diagnosis, consultation, transfer of the patient, di...
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Sjögren's syndrome (SS) is an autoimmune disease with mononuclear cell infiltration and destruction of the lacrimal gland and salivary glands, which cause dryness of the eyes and mouth. The most common neurological condition seen in... more
Sjögren's syndrome (SS) is an autoimmune disease with mononuclear cell infiltration and destruction of the lacrimal gland and salivary glands, which cause dryness of the eyes and mouth. The most common neurological condition seen in SS is peripheral neuropathy. Initial manifestation of SS as an acute fulminant peripheral neuropathy is extremely rare. We report a 42-year-old patient presenting with acute motor sensory-axonal neuropathy in the presence of SS. She showed partial response to intravenous immunoglobulin but favourable clinical improvement was seen after initiation of corticosteroid treatment.
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The association of coronary artery disease (CAD) severity with increased C-reactive protein (CRP) and decreased albumin levels has been reported. However, to our knowledge, no study has investigated the usefulness of the CRP to albumin... more
The association of coronary artery disease (CAD) severity with increased C-reactive protein (CRP) and decreased albumin levels has been reported. However, to our knowledge, no study has investigated the usefulness of the CRP to albumin ratio (CAR) in predicting intermediate–high SYNergy between Percutaneous Coronary Intervention with TAXus and cardiac surgery (SYNTAX) score (SS) and high SS II. Consecutive patients (n = 344) treated with percutaneous coronary intervention comprised the study population. The study population was divided into 2 groups according to SS >22 and mean SS II values, respectively. Patients with intermediate–high SS and high SS II had higher CAR than patients with low SS and SS II. History of diabetes mellitus, decreased albumin, lower left ventricular ejection fraction, and elevated CAR (odds ratio [OR]: 1.020; 95% confidence interval [CI], 1.009-1.031; P < .001) were independent predictors of high SS. The presence of hypertension, decreased hemoglobin...
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Research Interests: Medicine and Anesthesia
The goal of the study was to identify whether the stroke etiology play a role in the recanalization and outcome of patients who underwent mechanical thrombectomy with stent retrievers. A retrospective analysis of a prospectively collected... more
The goal of the study was to identify whether the stroke etiology play a role in the recanalization and outcome of patients who underwent mechanical thrombectomy with stent retrievers. A retrospective analysis of a prospectively collected database included consecutive patients treated with stent retrievers. We included patients with cardioembolic stroke and large vessel atherosclerotic disease and compared risk factors for stroke, baseline NIHSS and Alberta Stroke Program Early CT scores (ASPECTS), stroke outcome, recanalization rate, onset-to-recanalization, onset-to-groin puncture time and the procedural time between two groups. Male sex was statistically more common in patients with large vessel atherosclerotic disease. Mean time from symptom onset- to the achievement of recanalization in patients with LVAD was 242±72.4 compared with cardioembolic stroke patients (301±70.7; p=0.014). Time for groin puncture to recanalization was longer in patients with cardioembolic stroke compared to LVAD group (97.5±44.3 vs 58.2±21.8; p=0.002). Time for microcatheter to successful recanalization or procedural termination was longer in patients with cardioembolic stroke compared to LVAD group (63.6±30.2 vs 34.2±19.4; p&amp;amp;lt;0.001) with cardioembolic stroke had significantly worse long-term outcome (mRS 3-6) compared to those with LVAD (60.6% vs 26.3%; p=0.036). Stroke etiology may play a role in the outcome of acute stroke patients who underwent endovascular stroke therapy. Cardioembolic strokes may be more resistant to endovascular acute stroke treatment.
Research Interests: Medicine, Prospective studies, Humans, Female, Male, and 15 moreBrain Ischemia, Etiology, Risk factors, Clinical Sciences, Middle Aged, Sex Factors, Retrospective Studies, Prognosis, Cardiovascular Diseases, Risk Factors, Stent, Neurosciences, Endovascular Procedures, Cerebral Angiography, and Severity of Illness Index
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Although some of the aetiological factors of seizure, such as cerebral microemboli, cerebral oedema, hypoperfusion, cerebral hypoxia and metabolic encephalopathy cannot be completely controlled during cardiac surgery, cautious management... more
Although some of the aetiological factors of seizure, such as cerebral microemboli, cerebral oedema, hypoperfusion, cerebral hypoxia and metabolic encephalopathy cannot be completely controlled during cardiac surgery, cautious management of all steps in the procedure may prevent the administrative causes of seizure. Cefazolin, which is known to be a proconvulsant agent, may be a suspected agent of seizure complications in patients with renal insufficiency. Surprisingly, intravenous bolus administration of cefazolin may also trigger seizure in patients with normal renal function. In this case report, a complication of generalised seizure after cardiac surgery with intravenous bolus administration of cefazolin is described, along with a brief review of the literature.
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We assessed the effectiveness of interferential current (IFC) and transcutaneous electrical nerve stimulation (TENS) therapies in the management of carpal tunnel syndrome (CTS) compared with splint therapy, a standard treatment modality... more
We assessed the effectiveness of interferential current (IFC) and transcutaneous electrical nerve stimulation (TENS) therapies in the management of carpal tunnel syndrome (CTS) compared with splint therapy, a standard treatment modality for CTS. This was a prospective, single-blinded, single-center, randomized, three-group parallel intervention study of 3 weeks duration. Efficacy was examined in the third week after the end of treatments. Subjects were assigned randomly to one of three groups: group I patients received splint therapy, group II patients received TENS applied on the palmar surface of the hand and the carpal tunnel, and group III patients underwent IFC therapy applied on the palmar surface of the hand and the volar surface of the forearm. TENS and ICF treatments were applied five times weekly for a total of 15 sessions. Group 1 patients were stabilized with volar wrist splints for 3 weeks. The efficacy of the therapies was assessed before initiation of therapy and at 3 weeks after completion of therapy using a visual analog scale (VAS), a symptom severity scale, the functional capacity scale of the BCTQ, and measurement of median nerve motor distal latency (mMDL) and median sensory nerve conduction velocity (mSNCV). Groups were compared pairwise using the Mann-Whitney U test to identify the source of differences between groups. The Wilcoxon test was used to analyze changes in variables over time within a group. In the VAS, BCTQ, MDL, and mSNCV, no significant difference was observed between the groups (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). In the VAS, BCTQ, and mSNCV, statistically significant improvements were detected in all groups (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). There was no statistically significant difference between TENS and splint therapy with respect to improvement in clinical scores, whereas IFC therapy provided a significantly greater improvement in VAS, mMDL, and mSNCV values than splint therapy (VAS: 4.80 ± 1.18 and 6.37 ± 1.18; p = 0.001, mMDL: 3.89 ± 0.88 and 4.06 ± 0.61; p = 0.001, mSNCV: 41.80 ± 1.76 and 40.75 ± 1.48; p = 0.010). IFC therapy provided a significantly greater improvement in VAS, symptom severity, functional capacity, and mMDL and mSNCV values than TENS therapy (VAS: 4.80 ± 1.18 and 6.68 ± 1.42; p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, symptom severity: 2.70 ± 1.03 and 3.37 ± 1.21; p = 0.015, functional capacity: 1.90 ± 1.21 and 2.50 ± 0.78; p = 0.039, mMDL: 3.89 ± 0.88 and 4.06 ± 0.88; p = 0.003, and mSNCV: 41.80 ± 1.76 and 41.38 ± 1.78; p = 0.021). IFC may be considered a new and safe therapeutic option for the treatment of CTS.
Research Interests: Rheumatology, Medicine, Prospective studies, Humans, Female, and 15 moreMale, Reaction Time, Transcutaneous Electrical Nerve Stimulation, Carpal Tunnel Syndrome, Clinical Sciences, Adult, Time Factors, Randomized Controlled Trial, Splints, Median Nerve, Forearm, Neurologic Examination, Severity of Illness Index, Recovery of Function, and Disability Evaluation
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Amaç: İnme, Türkiye’de tüm ölümlerin %15 nedenidir. Akut iskemik inmede(Aİİ) tıkanın damarın açılmadığı her dakikada nöron harabiyeti devam etmektedir ve bugün için Aİİ’nin erken dönem en önemli tedavisi tıkalı damarın hızlı ve etkili... more
Amaç: İnme, Türkiye’de tüm ölümlerin %15 nedenidir. Akut iskemik inmede(Aİİ) tıkanın damarın açılmadığı her dakikada nöron harabiyeti devam etmektedir ve bugün için Aİİ’nin erken dönem en önemli tedavisi tıkalı damarın hızlı ve etkili şekilde açılmasıdır. Biz bu çalışmada merkezimizdeki inme hastalarına uygulanan endovasküler tedavi deneyimlerimizi paylaşmayı amaçladık. Materyal ve method: Ocak 2015 ve Kasım 2018 arasında başvuran, Aİİ tanısı konarak endovasküler tedavi alan ardışık ilk 100 hastanın klinik ve demografik özelliklerini ve endovasküler işlem özelliklerini kaydettik. Bulgular: Çalışmaya dahil edilen 100 hastanın 49’u kadın, 51’i erkekti ve yaş ortalamaları 65(55-74) idi. Hastaların %74’ünde hipertansiyon, %25’inde hiperlipidemi, %38’inde diabetes mellitus, %26’sınde atrial fibrilasyon, %36’ünde koroner arter hastalığı ve %39’ünde sigara kullanımı mevcuttu. Hastaların tedavi öncesi National Institutes of Health Stroke Scale (NIHSS) skoru 15,5 (13-19) idi. Üç aylık takipt...