Papers by Mohammad Nazmul Hoque Jony
Discovery Phytomedicine, 2018
Background: Sterculia cordata is a flowering plant and belongs to the family Malvaceae. The goal ... more Background: Sterculia cordata is a flowering plant and belongs to the family Malvaceae. The goal of our investigation was to determine the significant medicinal properties of the leaf of this plant. Methods: Leaves of Sterculia cordata was extracted with pure ethanol, then fractioned with n-hexane, Ethyl acetate, chloroform and methanol. The extract and fractions were tested for secondary metabolites and the determination of total phenol, total flavonoid content and antioxidant activity. The antibacterial screening was done by disk diffusion technique. The cytotoxic bioassay was carried out with the method as described by brine shrimp bioassay. Results: Alkaloid, flavonoid, terpenoid, and tannins are present in all extracts and fractions of Sterculia cordata leaves. Among all extract and fractions, MFEESC exhibited strong antioxidant activity in both reducing powers. Phenol content was at a range of 3.06 ± 0.34 mg to
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This study aims to predict whether the isolated compounds from Flemingia macrophylla have thrombo... more This study aims to predict whether the isolated compounds from Flemingia macrophylla have thrombolytic effects, which were done by using two in silico tools PASS prediction and Molecular docking. Nine phytoconstituents namely beta-sitosterol, cajanin, flemichin E, flemiflavanone A, fleminone, genistein, genistin, kushenol E, neoraufurane, prunetin and stigmasterol were analyzed by the PASS prediction for their thrombolytic activity and found wide range of activity. Flemichin E was the best compound for thrombolytic effect
from all the compounds, though it had much bigger Pa value (0.466) than Pi value (0.004). As a result, flemichin E had 116.5 ratio (Pa : Pi) value. A wide range of docking score found during molecular docking by CPI server. Beta-sitosterol, cajanin, flemichin E, flemiflavanone A, genistein, genistin, kushenol E, neoraufurane and prunetin showed the docking score -7.9, -
8.4, -8.8, -8.6, -8.0, -8.6, -8.7, -8.3 and -7.9, respectively. Data from the both in silico models showed similar values for the same compound, because flemichin E showed high value and
beta-sitosterol, prunetin showed low value in both in silico models. All the data supported that flemichin E is the best compound for thrombosis management, as it possessed higher
value both in PASS prediction and Molecular docking. After flemichin E, genistin showed well docking score (-8.6) and good prediction for thrombolytic effect in PASS prediction.
Further in vitro and in vivo investigation need to identify whether flemichin E, genistin and other compounds have thrombolytic effect or not.
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Papers by Mohammad Nazmul Hoque Jony
from all the compounds, though it had much bigger Pa value (0.466) than Pi value (0.004). As a result, flemichin E had 116.5 ratio (Pa : Pi) value. A wide range of docking score found during molecular docking by CPI server. Beta-sitosterol, cajanin, flemichin E, flemiflavanone A, genistein, genistin, kushenol E, neoraufurane and prunetin showed the docking score -7.9, -
8.4, -8.8, -8.6, -8.0, -8.6, -8.7, -8.3 and -7.9, respectively. Data from the both in silico models showed similar values for the same compound, because flemichin E showed high value and
beta-sitosterol, prunetin showed low value in both in silico models. All the data supported that flemichin E is the best compound for thrombosis management, as it possessed higher
value both in PASS prediction and Molecular docking. After flemichin E, genistin showed well docking score (-8.6) and good prediction for thrombolytic effect in PASS prediction.
Further in vitro and in vivo investigation need to identify whether flemichin E, genistin and other compounds have thrombolytic effect or not.
from all the compounds, though it had much bigger Pa value (0.466) than Pi value (0.004). As a result, flemichin E had 116.5 ratio (Pa : Pi) value. A wide range of docking score found during molecular docking by CPI server. Beta-sitosterol, cajanin, flemichin E, flemiflavanone A, genistein, genistin, kushenol E, neoraufurane and prunetin showed the docking score -7.9, -
8.4, -8.8, -8.6, -8.0, -8.6, -8.7, -8.3 and -7.9, respectively. Data from the both in silico models showed similar values for the same compound, because flemichin E showed high value and
beta-sitosterol, prunetin showed low value in both in silico models. All the data supported that flemichin E is the best compound for thrombosis management, as it possessed higher
value both in PASS prediction and Molecular docking. After flemichin E, genistin showed well docking score (-8.6) and good prediction for thrombolytic effect in PASS prediction.
Further in vitro and in vivo investigation need to identify whether flemichin E, genistin and other compounds have thrombolytic effect or not.