xin sheng mao

The method establishing point,line and surface from bottom to top is usually used to establish the two-dimensional modelling for a complex geologic body,in which the definition for surface would be finished manually,so to consume time and effort.Aimed at the insufficiency of the ...

The method combining the finite element computation module Sigma/W and the rigid body limit equilibrium computation module Slope/W of Geo-Slope software is proposed to analyze the stability of soil slope.Considering the stres-strain relation of soil body and leading the results from ...

Many factors influence the stability of slope. The orthogonal design to carry on the sensitive analysis of the multi-factors which affect the slope??? s stability is applied. Firstly, the principle of orthogonal design and range analysis and variance analysis are introduced which are ...

This study investigated vascular endothelial growth factor (VEGF) and flk-1 expression in hepatic metastases from colon carcinoma, and their associations with tumor angiogenesis, proliferation, and apoptosis. Immunohistochemical studies were performed for VEGF/flk-1, Ki-67, p53, and bcl-2 expression, and microvessel density (MVD) in surgical specimens from 35 patients who underwent hepatectomy for colon cancer liver metastases between 1986 and 2001. VEGF and flk-1 were expressed mainly in the cytoplasm of tumor cells. High VEGF expression was associated with high flk-1 expression (P = 0.043). MVDs of less than 15 and 15 or more were found in 5 (14.3%) and 30 (85.7%) of 35 hepatic metastases, respectively. A Ki-67 index (KI) of 50% or more was detected in 33/35 (94.3%) of tumors, and 23 of these (65.7%) showed a KI of 85% or more. A KI of less than 50% was present in 2/35 (5.7%) of tumors. The expression of VEGF/flk-1 was related to elevated MVD (P < or = 0.026). VEGF was also associated with an increased KI (P = 0.025). Mutant p53 and bcl-2 expressions were detected in 26/35 (74.3%) and 17/35 (48.6%) of liver metastases, respectively. Mutant p53 was not related to VEGF/flk-1 expression, but bcl-2 was highly associated with flk-1 (P = 0.007). The incidences of high flk-1 expression and a KI of 85% or more were significantly higher in tumors which were both p53- and bcl-2-positive (93.3% and 73.3%) than in tumors which were negative for both (42.9% and 14.3%; P < or = 0.021). The VEGF-flk-1 system takes part in tumor angiogenesis, proliferation, and apoptosis in colon liver metastases. The bcl-2 pathway may upregulate VEGF activity via the flk-1 receptor. These findings are preliminary, requiring a larger sampling in order to elucidate the role of VEGF/flk-1 in metastatic colon cancer.

When the earthquake hit, several members of what became an international, volunteer, disaster-management IT team were attending a workshop in Washington, DC The workshop was organized by the IBM Office of Corporate Citizenship and Corporate Affairs ...

The paper describes the principle of RMR method and direct method of fuzzy pattern recognition,and briefs the Hoek-Brown criterion and the latest estimation method of rock mass strength.Based on project case histories,the surrounding rock quality is evaluated by the ...

Abstract Software as a service (SaaS) is an important technology innovation as well as a business model innovation to bring new opportunities to small and medium enterprises (SME). There are different SaaS provisioning methods, depending on the customer profile, ...