Saharnaz Ahmadi
Islamic Azad Universty, Biology, Faculty Member
Endometriosis is a chronic inflammation of the immune system and most cytokines are involved in it.RAGE is transmembrane is transmembrane is transmembrane is transmembrane protein and member of the immunoglobulin superfamily and its role... more
Endometriosis is a chronic inflammation of the immune system and most cytokines are involved in it.RAGE is transmembrane is transmembrane is transmembrane is transmembrane protein and member of the immunoglobulin superfamily and its role in this disease has been proved.RAGE RAGE RAGE (receptor for advanced glycosylation end products) is expressed in endothelial cells, (receptor for advanced glycosylation end products) is expressed in endothelial cells, (receptor for advanced glycosylation end products) is expressed in endothelial cells, (receptor for advanced glycosylation end products) is expressed in endothelial cells, (receptor for advanced glycosylation end products) is expressed in endothelial cells, (receptor for advanced glycosylation end products) is expressed in endothelial cells, (receptor for advanced glycosylation end products) is expressed in endothelial cells, (receptor for advanced glycosylation end products) is expressed in endothelial cells, (receptor for advanced g...
In this study the effect of surface modification of mesoporous silica nanoparticles (MSNs) on its adsorption capacities and protein stability after immobilization of beta-lactoglobulin B (BLG-B) was investigated. For this purpose,... more
In this study the effect of surface modification of mesoporous silica nanoparticles (MSNs) on its adsorption capacities and protein stability after immobilization of beta-lactoglobulin B (BLG-B) was investigated. For this purpose, non-functionalized (KIT-6) and aminopropyl-functionalized cubic Ia3d mesoporous silica ([n-PrNH2-KIT-6]) nanoparticles were used as nanoporous supports. Aminopropyl-functionalized mesoporous nanoparticles exhibited more potential candidates for BLG-B adsorption and minimum BLG leaching than non-functionalized nanoparticles. It was observed that the amount of adsorbed BLG is dependent on the initial BLG concentration for both KIT-6 and [n-PrNH2-KIT-6] mesoporous nanoparticles. Also larger amounts of BLG-B on KIT-6 was immobilized upon raising the temperature of the medium from 4 to 55 °C while such increase was undetectable in the case of immobilization of BLG-B on the [n-PrNH2-KIT-6]. At temperatures above 55 °C the amounts of adsorbed BLG on both studied nanomaterials decreased significantly. By Differential scanning calorimetry or DSC analysis the heterogeneity of the protein solution and increase in Tm may indicate that immobilization of BLG-B onto the modified KIT-6 results in higher thermal stability compared to unmodified one. The obtained results provide several crucial factors in determining the mechanism(s) of protein adsorption and stability on the nanostructured solid supports and the development of engineered nano-biomaterials for controlled drug-delivery systems and biomimetic interfaces for the immobilization of living cells.
Research Interests:
The vibrational energy is produced by most of the machines and it is possible to transfer to people working with them. Two groups were compared to evaluate disorders caused by vibrational energy. Test group involved carpenters exposed to... more
The vibrational energy is produced by most of the machines and it is possible to transfer to people working with them. Two groups were compared to evaluate disorders caused by vibrational energy. Test group involved carpenters exposed to vibration and control groups consisted of teachers. Data were gathered by interviewing, completing questionnaire and analyzing optic nerve tests. In questionnaire the effects of vibration on sensing and movement of organs were assessed. Obtained data were coded and analyzed by statistical tests and soft wares. The results revealed that in test group optic nerve disorder were observed in some subjects in comparison with control group in which no damage among participants was detected. In addition, the observed disorders in test group were significant statistically. In conclusion, the people who are exposed to vibration must be monitored regularly to diagnose the effects of vibration. Also, some approaches like regular operator training, building suit...