G. Bozkurt
Hacettepe University, Neurosurgery, Faculty Member
Research Interests:
In this study we investigated whether pretreatment with melatonin was protective against the injury of the central nervous system (CNS) in rats receiving LD(50) whole body irradiation. The wistar rats were randomized into four groups: i)... more
In this study we investigated whether pretreatment with melatonin was protective against the injury of the central nervous system (CNS) in rats receiving LD(50) whole body irradiation. The wistar rats were randomized into four groups: i) the control group (CG), ii) melatonin-administered group (MG; 1 mg/kg body weight), iii) irradiated group (RG; 6.75 Gy, one dose), and iv) melatonin-administered and irradiated group (MRG). Blood samples were drawn from the rats 24 h after the treatment and plasma glutathione levels were assayed. Plasma glutathione level was significantly higher in RG than CG. The melatonin pretreatment prevented GSH increase induced by irradiation. Lipid peroxidation and glutathione levels of rat cerebral cortex were determined in all groups after 24 h. Cortical malondialdehyde (MDA) was significantly higher in the RG. The melatonin pretreatment prevented cortical MDA increase induced by irradiation. Cortical GSH was significantly lower in RG than the CG. The melat...
Research Interests:
Randomized controlled. To evaluate the effects of Tamoxifen (TMX) and trifluoperozine (TFP) on pinealectomized chicken scoliosis. Pinealectomized chicken develops scoliosis probably due to the lack of melatonin. In addition to other... more
Randomized controlled. To evaluate the effects of Tamoxifen (TMX) and trifluoperozine (TFP) on pinealectomized chicken scoliosis. Pinealectomized chicken develops scoliosis probably due to the lack of melatonin. In addition to other functions, melatonin also acts as a calmodulin antagonist. We postulate that loss of this antagonistic effect may be the cause of scoliosis in this model. TMX and TFP are known calmodulin antagonists, which may alter the incidence and severity of scoliosis. Seventy-two newly hatched chicken that underwent surgical pinealectomy within 72 hours of hatching were divided into 3 groups of 24 animals in each as group I (control), group II (TMX), and group III (TFP). TMX and TFP were given to groups II and III, respectively, for 10 weeks with the dose of 0.1 mg/kg/d, whereas the control group received no medication. AP scoliosis radiographs were obtained at seventh and 10th week to evaluate coronal spinal alignment. Three chickens in group I, 2 chickens in group II, and 1 chicken in group III died in the first postoperative week. Scoliosis incidences and magnitudes were similar among groups at seventh and 10th week. TMX and TFP groups showed decreases of incidence of upper cervical, lower cervical, lower cervical-thoracic-lumbar curves at 10th week compared with seventh week. TMX group showed a decline in thoracic region mean Cobb angle, whereas control group showed an increase (P = 0.048). TMX group showed a more prominent decline in cervicothoracic region mean Cobb angle compared with control group (P = 0.009). The incidence and magnitude of scoliosis in pinealectomized chicken may be decreased by the administration of TMX, presumably because of this drugs' calmodulin antagonism. Further studies on higher animals and dosage and timing are required.
Research Interests:
Research Interests:
Turkish Neurosurgery.
OBJECTIVE: Aging, expressing postmaturational changes, is a process that contains a decline in the organism's simultaneous and harmonic response, adaptation potential, and resistance ability to external and negative events (stressors... more
OBJECTIVE: Aging, expressing postmaturational changes, is a process that contains a decline in the organism's simultaneous and harmonic response, adaptation potential, and resistance ability to external and negative events (stressors and stimuli). The free radical theory of ...
Discussion The frequency that of an acquired abducens nerve paresis is due to an intracranial aneurysm is between 3.3% and 3.6%[4]. Isolated or combined pareses of the abducens nerve may be seen with aneurysms of infraclinoid internal... more
Discussion The frequency that of an acquired abducens nerve paresis is due to an intracranial aneurysm is between 3.3% and 3.6%[4]. Isolated or combined pareses of the abducens nerve may be seen with aneurysms of infraclinoid internal carotid, ...
Research Interests:
Study design:Experimental investigation of intrathecal transplantation of stem cells by lumbar puncture (LP) in a rat model that simulates human thoracic spinal cord injury (SCI).Objectives:To examine the distribution and phenotype of... more
Study design:Experimental investigation of intrathecal transplantation of stem cells by lumbar puncture (LP) in a rat model that simulates human thoracic spinal cord injury (SCI).Objectives:To examine the distribution and phenotype of spinal cord-derived neural stem/progenitor cells (NSPCs) and bone marrow-derived mesenchymal stromal cells (BMSCs) following LP transplantation in SCI rats.Setting:Toronto Western Research Institute, Toronto, Ontario, Canada.Methods:NSPCs or BMSCs were transplanted