Drug Interactions: This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions: Not Available

Products

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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 1000 ML	Chloride ion (24 mmol) + Acetate (27 mmol) + Alanine (3.66 g) + Arginine (2.48 g) + Aspartic acid (0.73 g) + Calcium (2 mmol) + Calcium chloride dihydrate (0.3 g) + D-glucose (75 g) + Glutamic acid (1.26 g) + Glycine (1.76 g) + Histidine (1.51 g) + Isoleucine (1.26 g) + Leucine (1.76 g) + Lysine (1.99 g) + Magnesium (2.2 mmol) + Magnesium chloride hexahydrate (0.45 g) + Methionine (1.26 g) + Olive oil (6 g) + Phenylalanine (1.76 g) + Phosphate ion (8.5 mmol) + Potassium (16 mmol) + Potassium chloride (1.19 g) + Proline (1.51 g) + Serine (1 g) + Sodium acetate trihydrate (1.16 g) + Sodium cation (21 mmol) + Sodium glycerophosphate hydrate (1.91 g) + Soybean oil (6 g) + Threonine (1.26 g) + Tryptophan (0.42 g) + Tyrosine (0.06 g) + Valine (1.62 g)	Injection, emulsion	Intravenous	EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.	2020-08-14	Not applicable
PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 1500 ML	Chloride ion (37 mmol) + Acetate (41 mmol) + Alanine (5.5 g) + Arginine (3.72 g) + Aspartic acid (1.1 g) + Calcium (3 mmol) + Calcium chloride dihydrate (0.44 g) + D-glucose (112.5 g) + Glutamic acid (1.9 g) + Glycine (2.63 g) + Histidine (2.26 g) + Isoleucine (1.9 g) + Leucine (2.63 g) + Lysine (2.99 g) + Magnesium (3.3 mmol) + Magnesium chloride hexahydrate (0.67 g) + Methionine (1.9 g) + Olive oil (9 g) + Phenylalanine (2.63 g) + Phosphate ion (12.7 mmol) + Potassium (24 mmol) + Potassium chloride (1.79 g) + Proline (2.26 g) + Serine (1.5 g) + Sodium acetate trihydrate (1.73 g) + Sodium cation (31.5 mmol) + Sodium glycerophosphate hydrate (2.87 g) + Soybean oil (9 g) + Threonine (1.9 g) + Tryptophan (0.64 g) + Tyrosine (0.1 g) + Valine (2.43 g)	Injection, emulsion	Intravenous	EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.	2020-08-14	Not applicable
PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 2000 ML	Chloride ion (49 mmol) + Acetate (55 mmol) + Alanine (7.33 g) + Arginine (4.96 g) + Aspartic acid (1.46 g) + Calcium (4 mmol) + Calcium chloride dihydrate (0.59 g) + D-glucose (150 g) + Glutamic acid (2.53 g) + Glycine (3.51 g) + Histidine (3.02 g) + Isoleucine (2.53 g) + Leucine (3.51 g) + Lysine (3.98 g) + Magnesium (4.4 mmol) + Magnesium chloride hexahydrate (0.9 g) + Methionine (2.53 g) + Olive oil (12 g) + Phenylalanine (3.51 g) + Phosphate ion (17 mmol) + Potassium (32 mmol) + Potassium chloride (2.38 g) + Proline (3.02 g) + Serine (2 g) + Sodium acetate trihydrate (2.31 g) + Sodium cation (42 mmol) + Sodium glycerophosphate hydrate (3.82 g) + Soybean oil (12 g) + Threonine (2.53 g) + Tryptophan (0.85 g) + Tyrosine (0.13 g) + Valine (3.24 g)	Injection, emulsion	Intravenous	EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.	2020-08-14	Not applicable
PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 2500 ML	Chloride ion (61 mmol) + Acetate (69 mmol) + Alanine (9.16 g) + Arginine (6.2 g) + Aspartic acid (1.83 g) + Calcium (5 mmol) + Calcium chloride dihydrate (0.74 g) + D-glucose (187.5 g) + Glutamic acid (3.16 g) + Glycine (4.39 g) + Histidine (3.77 g) + Isoleucine (3.16 g) + Leucine (4.39 g) + Lysine (4.98 g) + Magnesium (5.5 mmol) + Magnesium chloride hexahydrate (1.12 g) + Methionine (3.16 g) + Olive oil (15 g) + Phenylalanine (4.39 g) + Phosphate ion (21.2 mmol) + Potassium (40 mmol) + Potassium chloride (2.98 g) + Proline (3.77 g) + Serine (2.5 g) + Sodium acetate trihydrate (2.89 g) + Sodium cation (52.5 mmol) + Sodium glycerophosphate hydrate (4.78 g) + Soybean oil (15 g) + Threonine (3.16 g) + Tryptophan (1.06 g) + Tyrosine (0.16 g) + Valine (4.05 g)	Injection, emulsion	Intravenous	EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.	2020-08-14	Not applicable
POLİFLEKS LAKTATLI RİNGER IV İNFÜZYON İÇİN ÇÖZELTİ, 100 ML (PVC TORBA) SETLI	Chloride ion (112 mEq/L) + Calcium cation (4 mEq/L) + Lactic acid (26.77 mEq/L) + Potassium cation (5.37 mEq/L) + Sodium cation (129.3 mEq/L)	Solution	Intravenous	POLİFARMA İLAÇ SAN. VE TİC. A.Ş.	2005-02-21	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Rurina	Chloride ion (0.11 g/1L) + Potassium cation (0.25 g/1L) + Sulfate ion (3.6 g/1L)	Liquid	Topical	TELOM-X GENE Co., Ltd.	2017-07-01	Not applicable
Rurina	Chloride ion (0.11 g/1L) + Potassium cation (0.25 g/1L) + Sulfate ion (3.6 g/1L)	Liquid	Topical	Nano Bio Tech Co.,Ltd	2017-07-01	Not applicable
Telom-X-gene	Chloride ion (0.11 g/1L) + Potassium cation (0.25 g/1L) + Sulfate ion (3.6 g/1L)	Liquid	Topical	TELOM-X GENE Co., Ltd.	2017-07-01	Not applicable

Chemical Identifiers

UNII: Q32ZN48698
CAS number: 16887-00-6
InChI Key: VEXZGXHMUGYJMC-UHFFFAOYSA-M
InChI: InChI=1S/ClH/h1H/p-1
IUPAC Name: chloride
SMILES: [Cl-]

References

General References

Not Available

External Links

Human Metabolome Database: HMDB0000492
KEGG Compound: C00698
ChemSpider: 306
BindingDB: 26979
RxNav: 153974
ChEBI: 17996
ChEMBL: CHEMBL19429
PDBe Ligand: CL
Wikipedia: Chloride

PDB Entries

102l / 103l / 107l / 108l / 109l / 110l / 111l / 112l / 113l / 114l …

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Clinical Trials

Clinical Trials Clinical Trial & Rare Diseases Add-on Data Package Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package

Phase	Status	Purpose	Conditions	Count	Start Date	Why Stopped	100+ additional columns
Unlock 175K+ rows when you subscribe.View sample data
Not Available	Completed	Not Available	Nasal Obstruction	1	somestatus	stop reason	just information to hide
Not Available	Completed	Basic Science	Pruritus	1	somestatus	stop reason	just information to hide
Not Available	Completed	Supportive Care	Postoperative pain	1	somestatus	stop reason	just information to hide
Not Available	Recruiting	Not Available	Cardiotoxicity / Evaluation Studies / Reactions Adverse	1	somestatus	stop reason	just information to hide
Not Available	Recruiting	Screening	Stage IB Non-Small Cell Lung Carcinoma AJCC v7 / Stage II Non-Small Cell Lung Cancer AJCC v7 / Stage IIA Lung Cancer AJCC v8 / Stage IIB Lung Cancer AJCC v8 / Stage IIIA Lung Cancer AJCC v8 / Stage IIIA Non-Small Cell Lung Cancer AJCC v7 / Stage IIIB Lung Cancer AJCC v8	1	somestatus	stop reason	just information to hide

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Tablet, film coated	Oral
Capsule	Oral
Injection, emulsion	Intravenous
Solution	Intravenous	100.000 mL
Solution	Intravenous	50.000 mL
Liquid	Topical
Solution	Intravenous

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
logP	0.61	Chemaxon
pKa (Strongest Acidic)	-7	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	0	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	0 Å²	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	5.62 m³·mol^-1	Chemaxon
Polarizability	2.39 Å³	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	Yes	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

Chromatographic Properties

Collision Cross Sections (CCS)

Adduct	CCS Value (Å²)	Source type	Source
[M-H]-	110.8201	predicted	DeepCCS 1.0 (2019)
[M+H]+	112.575516	predicted	DeepCCS 1.0 (2019)
[M+Na]+	119.57085	predicted	DeepCCS 1.0 (2019)

Targets

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Details1. Lanosterol 14-alpha demethylase

Kind: Protein
Organism: Yeast
Pharmacological action: Yes
Actions: Modulator

General Function: Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:10393548, PubMed:28258218, PubMed:8647850, PubMed:9559662). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity). In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity). Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (PubMed:10393548, PubMed:28258218, PubMed:8647850, PubMed:9559662). Can also use substrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity).
Specific Function: heme binding
Gene Name: ERG11
Uniprot ID: P10613
Uniprot Name: Lanosterol 14-alpha demethylase
Molecular Weight: 60674.965 Da

References

Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]

Drug created at July 12, 2018 21:42 / Updated at August 26, 2024 19:23

Chloride ion

Identification

Structure for Chloride ion (DB14547)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Clinical Trial & Rare Diseases Add-on Data Package

Pharmacoeconomics

Properties

Spectra

Collision Cross Sections (CCS)

Targets

References