Solute carrier family 22 member 2

Details

Name
Solute carrier family 22 member 2
Kind
protein
Synonyms
  • hOCT2
  • OCT2
  • Organic cation transporter 2
Gene Name
SLC22A2
UniProtKB Entry
O15244Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0037250|Solute carrier family 22 member 2
MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS
LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG
PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL
LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF
YQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAM
RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV
LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA
SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII
TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE
KMIYLQVQKLDIPLN
Number of residues
555
Molecular Weight
62579.99
Theoretical pI
8.45
GO Classification
Functions
choline transmembrane transporter activity / organic cation transmembrane transporter activity / quaternary ammonium group transmembrane transporter activity
Processes
body fluid secretion / choline transport / dopamine transport / organic cation transport
Components
extracellular exosome / membrane / plasma membrane
General Function
Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:9260930, PubMed:9687576). Functions as a Na(+)-independent, bidirectional uniporter (PubMed:21128598, PubMed:9687576). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:15212162, PubMed:9260930, PubMed:9687576). However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (By similarity). Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (PubMed:15783073). Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters (PubMed:16581093, PubMed:17460754, PubMed:9687576). Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system (PubMed:17460754). Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium (PubMed:15817714). Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN) (PubMed:12089365, PubMed:15212162, PubMed:17072098, PubMed:24961373, PubMed:9260930). Mediates the uptake and efflux of quaternary ammonium compound choline (PubMed:9260930). Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamines putrescine and spermidine (PubMed:12538837, PubMed:21128598). Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (PubMed:11907186). Also involved in the uptake of xenobiotic 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (PubMed:12395288, PubMed:16394027). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable)
Specific Function
acetylcholine transmembrane transporter activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
23-43 151-171 178-198 209-229 239-259 264-284 349-369 376-396 415-435 442-462 465-485 495-515
Cellular Location
Basolateral cell membrane
Gene sequence
>lcl|BSEQ0012536|Solute carrier family 22 member 2 (SLC22A2)
ATGCCCACCACCGTGGACGATGTCCTGGAGCATGGAGGGGAGTTTCACTTTTTCCAGAAG
CAAATGTTTTTCCTCTTGGCTCTGCTCTCGGCTACCTTCGCGCCCATCTACGTGGGCATC
GTCTTCCTGGGCTTCACCCCTGACCACCGCTGCCGGAGCCCCGGAGTGGCCGAGCTGAGT
CTGCGCTGCGGCTGGAGTCCTGCAGAGGAACTGAACTACACGGTGCCGGGCCCAGGACCT
GCGGGCGAAGCCTCCCCAAGACAGTGTAGGCGCTACGAGGTGGACTGGAACCAGAGCACC
TTCGACTGCGTGGACCCCCTGGCCAGCCTGGACACCAACAGGAGCCGCCTGCCACTGGGC
CCCTGCCGGGACGGCTGGGTGTACGAGACGCCTGGCTCGTCCATCGTCACCGAGTTTAAC
CTGGTATGTGCCAACTCCTGGATGTTGGACCTATTCCAGTCATCAGTGAATGTAGGATTC
TTTATTGGCTCTATGAGTATCGGCTACATAGCAGACAGGTTTGGCCGTAAGCTCTGCCTC
CTAACTACAGTCCTCATAAATGCTGCAGCTGGAGTTCTCATGGCCATTTCCCCAACCTAT
ACGTGGATGTTAATTTTTCGCTTAATCCAAGGACTGGTCAGCAAAGCAGGCTGGTTAATA
GGCTACATCCTGATTACAGAATTTGTTGGGCGGAGATATCGGAGAACAGTGGGGATTTTT
TACCAAGTTGCCTATACAGTTGGGCTCCTGGTGCTAGCTGGGGTGGCTTACGCACTTCCT
CACTGGAGGTGGTTGCAGTTCACAGTTTCTCTGCCCAACTTCTTCTTCTTGCTCTATTAC
TGGTGCATACCTGAGTCTCCCAGGTGGCTGATCTCCCAGAATAAGAATGCTGAAGCCATG
AGAATCATTAAGCACATCGCAAAGAAAAATGGAAAATCTCTACCCGCCTCCCTTCAGCGC
CTGAGACTTGAAGAGGAAACTGGCAAGAAATTGAACCCTTCATTTCTTGACTTGGTCAGA
ACTCCTCAGATAAGGAAACATACTATGATATTGATGTACAACTGGTTCACGAGCTCTGTG
CTCTACCAGGGCCTCATCATGCACATGGGCCTTGCAGGTGACAATATCTACCTGGATTTC
TTCTACTCTGCCCTGGTTGAATTCCCAGCTGCCTTCATGATCATCCTCACCATCGACCGC
ATCGGACGCCGTTACCCTTGGGCTGCATCAAATATGGTTGCAGGGGCAGCCTGTCTGGCC
TCAGTTTTTATACCTGGTGATCTACAATGGCTAAAAATTATTATCTCATGCTTGGGAAGA
ATGGGGATCACAATGGCCTATGAGATAGTCTGCCTGGTCAATGCTGAGCTGTACCCCACA
TTCATTAGGAATCTTGGCGTCCACATCTGTTCCTCAATGTGTGACATTGGTGGCATCATC
ACGCCATTCCTGGTCTACCGGCTCACTAACATCTGGCTTGAGCTCCCGCTGATGGTTTTC
GGCGTGCTTGGCTTGGTTGCTGGAGGTCTGGTGCTGTTGCTTCCAGAAACTAAAGGGAAA
GCTTTGCCTGAGACCATCGAGGAAGCCGAAAATATGCAAAGACCAAGAAAAAATAAAGAA
AAGATGATTTACCTCCAAGTTCAGAAACTAGACATTCCATTGAACTAA
Chromosome Location
6
Locus
6q25.3
External Identifiers
ResourceLink
UniProtKB IDO15244
UniProtKB Entry NameS22A2_HUMAN
GenBank Protein ID2281942
GenBank Gene IDX98333
GeneCard IDSLC22A2
HGNC IDHGNC:10966
PDB ID(s)8ET9
KEGG IDhsa:6582
IUPHAR/Guide To Pharmacology ID1020
NCBI Gene ID6582
General References
  1. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H: Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81. [Article]
  2. Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [Article]
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  6. Grundemann D, Schomig E: Gene structures of the human non-neuronal monoamine transporters EMT and OCT2. Hum Genet. 2000 Jun;106(6):627-35. [Article]
  7. Busch AE, Karbach U, Miska D, Gorboulev V, Akhoundova A, Volk C, Arndt P, Ulzheimer JC, Sonders MS, Baumann C, Waldegger S, Lang F, Koepsell H: Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52. [Article]
  8. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [Article]
  9. Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, Fukatsu A, Ogawa O, Inui K: Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol. 2002 Apr;13(4):866-74. [Article]
  10. Grundemann D, Hahne C, Berkels R, Schomig E: Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). J Pharmacol Exp Ther. 2003 Feb;304(2):810-7. [Article]
  11. Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. [Article]
  12. Ciarimboli G, Ludwig T, Lang D, Pavenstadt H, Koepsell H, Piechota HJ, Haier J, Jaehde U, Zisowsky J, Schlatter E: Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol. 2005 Dec;167(6):1477-84. [Article]
  13. Kimura N, Masuda S, Tanihara Y, Ueo H, Okuda M, Katsura T, Inui K: Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005 Oct;20(5):379-86. [Article]
  14. Tahara H, Kusuhara H, Endou H, Koepsell H, Imaoka T, Fuse E, Sugiyama Y: A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45. Epub 2005 Jul 8. [Article]
  15. Kimura N, Okuda M, Inui K: Metformin transport by renal basolateral organic cation transporter hOCT2. Pharm Res. 2005 Feb;22(2):255-9. [Article]
  16. Biermann J, Lang D, Gorboulev V, Koepsell H, Sindic A, Schroter R, Zvirbliene A, Pavenstadt H, Schlatter E, Ciarimboli G: Characterization of regulatory mechanisms and states of human organic cation transporter 2. Am J Physiol Cell Physiol. 2006 Jun;290(6):C1521-31. Epub 2006 Jan 4. [Article]
  17. Zhang S, Lovejoy KS, Shima JE, Lagpacan LL, Shu Y, Lapuk A, Chen Y, Komori T, Gray JW, Chen X, Lippard SJ, Giacomini KM: Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 1;66(17):8847-57. doi: 10.1158/0008-5472.CAN-06-0769. [Article]
  18. Okuda M, Kimura N, Inui K: Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2. Drug Metab Pharmacokinet. 2006 Oct;21(5):432-6. [Article]
  19. Yonezawa A, Masuda S, Yokoo S, Katsura T, Inui K: Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther. 2006 Nov;319(2):879-86. Epub 2006 Aug 16. [Article]
  20. Yokoo S, Yonezawa A, Masuda S, Fukatsu A, Katsura T, Inui K: Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity. Biochem Pharmacol. 2007 Aug 1;74(3):477-87. Epub 2007 Mar 12. [Article]
  21. Bottalico B, Noskova V, Pilka R, Larsson I, Domanski H, Casslen B, Hansson SR: The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua. Mol Reprod Dev. 2007 Oct;74(10):1303-11. [Article]
  22. Leabman MK, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Clark AG, Herskowitz I, Giacomini KM: Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics. 2002 Jul;12(5):395-405. [Article]
  23. Shikata E, Yamamoto R, Takane H, Shigemasa C, Ikeda T, Otsubo K, Ieiri I: Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin. J Hum Genet. 2007;52(2):117-22. Epub 2006 Nov 17. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Propranololapproved, investigationalunknowntransporterinhibitorDetails
OxprenololapprovedunknowntransporterinhibitorDetails
Metoprololapproved, investigationalunknowntransporterinhibitorDetails
QuinineapprovedunknowntransporterinhibitorDetails
Cholineapproved, nutraceuticalunknowntransportersubstrateinhibitorDetails
DinoprostoneapprovedunknowntransporterinhibitorDetails
Thiamineapproved, investigational, nutraceutical, vet_approvedunknowntransporterinhibitorDetails
Quinidineapproved, investigationalunknowntransporterinhibitorDetails
ProcainamideapprovedunknowntransporterinhibitorDetails
NorepinephrineapprovedunknowntransportersubstrateinhibitorDetails
NicotineapprovedunknowntransporterinhibitorDetails
Levofloxacinapproved, investigationalunknowntransporterinhibitorDetails
ImipramineapprovedunknowntransporterinhibitorDetails
Histamineapproved, investigationalunknowntransportersubstrateinhibitorDetails
GuanidineapprovedunknowntransporterinhibitorDetails
Grepafloxacinapproved, investigational, withdrawnunknowntransporterinhibitorDetails
DopamineapprovedunknowntransportersubstrateinhibitorDetails
Cimetidineapproved, investigationalunknowntransportersubstrateinhibitorDetails
AmantadineapprovedunknowntransportersubstrateinhibitorDetails
Progesteroneapproved, vet_approvedunknowntransporterinhibitorDetails
PhenoxybenzamineapprovedunknowntransporterinhibitorDetails
Estradiolapproved, investigational, vet_approvedunknowntransporterinhibitordownregulatorDetails
Phenforminapproved, investigational, withdrawnunknowntransporterinhibitorDetails
MetforminapprovedunknowntransportersubstrateinhibitorDetails
Desipramineapproved, investigationalunknowntransporterinhibitorDetails
FamotidineapprovednotransporterinhibitorDetails
Probenecidapproved, investigationalunknowntransporterinhibitorDetails
Aminohippuric acidapproved, investigationalunknowntransporterinhibitorDetails
Cocaineapproved, illicitunknowntransporterinhibitorDetails
CisplatinapprovedunknowntransportersubstrateinhibitorDetails
QuinacrineinvestigationalunknowntransporterinhibitorDetails
ChlorpheniramineapprovedunknowntransporterinhibitorDetails
AmilorideapprovedunknowntransporterinhibitorDetails
Epinephrineapproved, vet_approvedunknowntransportersubstrateDetails
DisopyramideapprovedunknowntransporterinhibitorDetails
Diphenhydramineapproved, investigationalunknowntransporterinhibitorDetails
ImatinibapprovednotransporterinhibitorDetails
PimagedineinvestigationalunknowntransporterinhibitorDetails
Memantineapproved, investigationalunknowntransportersubstrateDetails
Pramipexoleapproved, investigationalunknowntransportersubstrateDetails
Reserpineapproved, investigational, withdrawnunknowntransportersubstrateDetails
Oxaliplatinapproved, investigationalnotransportersubstrateDetails
Tetraethylammoniumexperimental, investigationalunknowntransportersubstrateDetails
Serotonininvestigational, nutraceuticalunknowntransporterDetails
N-methylnicotinamideexperimentalunknowntransporterDetails
ZidovudineapprovedunknowntransporterDetails
AgmatineexperimentalunknowntransportersubstrateDetails
TubocurarineapprovedunknowntransporterDetails
PancuroniumapprovedunknowntransporterDetails
Dinoprost tromethamineapproved, vet_approvedunknowntransporterDetails
Flurazepamapproved, illicit, investigationalunknowntransporterinhibitorDetails
Lamivudineapproved, investigationalunknowntransportersubstrateDetails
Dexchlorpheniramine maleateapprovedunknowncarrierinhibitorDetails
NafamostatinvestigationalunknowntransportersubstrateDetails
Enasidenibapproved, investigationalunknowntransporterinhibitorDetails
DolutegravirapprovednotransporterinhibitorDetails
Baricitinibapproved, investigationalunknowntransporterinhibitorDetails
Estradiol acetateapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Estradiol benzoateapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Estradiol cypionateapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Estradiol dienanthateapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Estradiol valerateapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Apalutamideapproved, investigationalnotransporterinhibitorDetails
Isavuconazoleapproved, investigationalunknowntransporterinhibitorDetails
Choline salicylateapproved, nutraceuticalunknowntransportersubstrateinhibitorDetails
Ranitidineapproved, withdrawnunknowntransportersubstrateDetails
Tafenoquineapproved, investigationalnotransporterinhibitorDetails
Lenvatinibapproved, investigationalunknowntransporterinhibitorDetails
Vareniclineapproved, investigationalunknowntransportersubstrateinhibitorDetails
BupropionapprovedunknowntransporterinhibitorDetails
DalfampridineapprovedunknowntransportersubstrateDetails
Amiodaroneapproved, investigationalunknowntransporterinhibitorDetails
ClopidogrelapprovednotransporterinhibitorDetails
Tipiracilapproved, investigationalunknowntransportersubstrateDetails
Dofetilideapproved, investigationalnotransportersubstrateDetails
Lamotrigineapproved, investigationalnotransporterinhibitorDetails
VandetanibapprovednotransporterinhibitorDetails
AllopurinolapprovedunknowntransporterDetails
SolriamfetolapprovedunknowntransporterDetails
Testosterone undecanoateapproved, investigationalunknowntransporterinducerDetails
LinagliptinapprovedunknowntransportersubstrateinhibitorDetails
Erdafitinibapproved, investigationalnotransporterinhibitorDetails
Lansoprazoleapproved, investigationalunknowntransporterDetails
DronedaroneapprovednotransporterinhibitorDetails
Abemaciclibapproved, investigationalunknowntransporterinhibitorDetails
Ubrogepantapproved, investigationalunknowntransporterinhibitorDetails
Guanfacineapproved, investigationalunknowntransportersubstrateDetails
SalmeterolapprovedunknowntransporterinhibitorDetails
Rimegepantapproved, investigationalunknowntransporterinhibitorDetails
Osilodrostatapproved, investigationalunknowntransporterinhibitorDetails
Methylene blueapproved, investigationalunknowntransporterinhibitorDetails
Tucatinibapproved, investigationalunknowntransporterinhibitorDetails
Pemigatinibapproved, investigationalnotransporterinhibitorDetails
Tirbanibulinapproved, investigationalnotransporterinhibitorDetails
Trilaciclibapproved, investigationalunknowntransporterinhibitorDetails
Sulpirideapproved, investigationalunknowntransportersubstrateDetails
TerbutalineapprovedunknowntransportersubstrateDetails
Pindololapproved, investigationalunknowntransportersubstrateDetails
MirabegronapprovednotransportersubstrateDetails
Glycopyrroniumapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Gentamicinapproved, vet_approvednotransportersubstrateDetails
Infigratinibapproved, investigationalnotransporterinhibitorDetails
Fexinidazoleapproved, investigationalunknowntransporterinhibitorDetails
Romidepsinapproved, investigationalnotransporterinhibitorDetails
Levoketoconazoleapproved, investigationalnotransporterinhibitorDetails
Pacritinibapproved, investigationalnotransporterinhibitorDetails
Dabrafenibapproved, investigationalnotransporterinhibitorDetails
Tepotinibapproved, investigationalnotransporterinhibitorDetails
Amifampridineapproved, investigationalnotransporterinhibitorDetails
Olutasidenibapproved, investigationalnotransporterinhibitorDetails
ClozapineapprovednotransporterDetails
Tezacaftorapproved, investigationalnotransporterinhibitorDetails
UmeclidiniumapprovednotransportersubstrateDetails
Encorafenibapproved, investigationalnotransporterinhibitorDetails
Capivasertibapproved, investigationalnotransporterinhibitorDetails
Isavuconazoniumapproved, investigationalnotransporterinhibitorDetails
Givinostatapproved, investigationalnotransporterinhibitorDetails
Mavorixaforapproved, investigationalunknowntransporterinhibitorDetails
Sofpironiumapproved, investigationalnotransporterinhibitorDetails
Arimoclomolapproved, investigationalnotransporterinhibitorDetails