Bifunctional protein MdtA
Details
- Name
- Bifunctional protein MdtA
- Kind
- protein
- Synonyms
- 1.5.1.-
- Gene Name
- mtdA
- UniProtKB Entry
- P55818Swiss-Prot
- Organism
- Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
- NCBI Taxonomy ID
- 272630
- Amino acid sequence
>lcl|BSEQ0017002|Bifunctional protein MdtA MSKKLLFQFDTDATPSVFDVVVGYDGGADHITGYGNVTPDNVGAYVDGTIYTRGGKEKQS TAIFVGGGDMAAGERVFEAVKKRFFGPFRVSCMLDSNGSNTTAAAGVALVVKAAGGSVKG KKAVVLAGTGPVGMRSAALLAGEGAEVVLCGRKLDKAQAAADSVNKRFKVNVTAAETADD ASRAEAVKGAHFVFTAGAIGLELLPQAAWQNESSIEIVADYNAQPPLGIGGIDATDKGKE YGGKRAFGALGIGGLKLKLHRACIAKLFESSEGVFDAEEIYKLAKEMA
- Number of residues
- 288
- Molecular Weight
- 29735.595
- Theoretical pI
- 7.43
- GO Classification
- Functionsmethylenetetrahydrofolate dehydrogenase (NADP+) activityProcessesformaldehyde catabolic process / one-carbon metabolic processComponentscytoplasm
- General Function
- Methylenetetrahydrofolate dehydrogenase (nadp+) activity
- Specific Function
- Catalyzes the dehydrogenation of methylene-H(4)MPT. Can also catalyze the reversible dehydrogenation of methylene-H(4)F with 20-fold lower catalytic efficiency.
- Pfam Domain Function
- Mpt_N (PF09176)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0017003|Bifunctional protein MdtA (mtdA) ATGTCCAAGAAGCTGCTCTTCCAGTTCGACACCGATGCCACGCCGAGCGTCTTCGACGTC GTCGTCGGCTACGACGGCGGTGCCGACCACATCACCGGCTACGGCAACGTCACGCCCGAC AACGTCGGCGCCTATGTCGACGGCACGATCTACACCCGCGGCGGCAAGGAGAAGCAGTCG ACGGCGATCTTCGTCGGCGGCGGCGACATGGCGGCCGGCGAGCGGGTGTTCGAGGCGGTG AAGAAGCGCTTCTTCGGCCCGTTCCGCGTGTCCTGCATGCTGGATTCGAACGGCTCCAAC ACGACCGCCGCGGCGGGTGTGGCGCTCGTCGTCAAGGCGGCGGGCGGCTCGGTCAAGGGC AAGAAGGCCGTCGTGCTCGCGGGCACCGGCCCGGTCGGCATGCGCTCGGCGGCGCTGCTC GCCGGCGAGGGCGCCGAGGTCGTGCTGTGCGGGCGCAAGCTCGACAAGGCGCAGGCCGCG GCCGATTCCGTGAACAAGCGCTTCAAGGTGAACGTCACCGCGGCCGAAACCGCGGACGAC GCTTCGCGCGCCGAGGCCGTGAAGGGCGCCCATTTCGTCTTCACCGCCGGTGCGATCGGC CTTGAACTGCTGCCGCAGGCAGCCTGGCAGAACGAGAGTTCGATCGAGATCGTGGCCGAC TACAACGCCCAGCCGCCGCTCGGCATCGGCGGGATCGATGCGACCGACAAAGGCAAGGAA TACGGCGGAAAGCGCGCCTTCGGTGCGCTCGGCATCGGCGGCTTGAAGCTCAAGCTGCAC CGCGCCTGCATCGCCAAGCTGTTCGAGTCGAGCGAAGGCGTCTTCGACGCCGAGGAGATC TACAAGCTGGCCAAGGAAATGGCCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P55818 UniProtKB Entry Name MTDA_METEA PDB ID(s) 1LU9, 1LUA KEGG ID mea:Mex_1p1728 - General References
- Chistoserdova LV, Lidstrom ME: Genetics of the serine cycle in Methylobacterium extorquens AM1: identification of sgaA and mtdA and sequences of sgaA, hprA, and mtdA. J Bacteriol. 1994 Apr;176(7):1957-68. [Article]
- Vuilleumier S, Chistoserdova L, Lee MC, Bringel F, Lajus A, Zhou Y, Gourion B, Barbe V, Chang J, Cruveiller S, Dossat C, Gillett W, Gruffaz C, Haugen E, Hourcade E, Levy R, Mangenot S, Muller E, Nadalig T, Pagni M, Penny C, Peyraud R, Robinson DG, Roche D, Rouy Z, Saenampechek C, Salvignol G, Vallenet D, Wu Z, Marx CJ, Vorholt JA, Olson MV, Kaul R, Weissenbach J, Medigue C, Lidstrom ME: Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources. PLoS One. 2009;4(5):e5584. doi: 10.1371/journal.pone.0005584. Epub 2009 May 18. [Article]
- Vorholt JA, Chistoserdova L, Lidstrom ME, Thauer RK: The NADP-dependent methylene tetrahydromethanopterin dehydrogenase in Methylobacterium extorquens AM1. J Bacteriol. 1998 Oct;180(20):5351-6. [Article]
- Hagemeier CH, Bartoschek S, Griesinger C, Thauer RK, Vorholt JA: Re-face stereospecificity of NADP dependent methylenetetrahydromethanopterin dehydrogenase from Methylobacterium extorquens AM1 as determined by NMR spectroscopy. FEBS Lett. 2001 Apr 6;494(1-2):95-8. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Nicotinamide adenine dinucleotide phosphate experimental unknown target Details