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ganesan11062001/README.md

Ganesan Murugan

Computational Biology · AI/ML · Protein Design · Cloud MLOps


👤 About Me

MS Bioinformatics candidate at Northeastern University (GPA 3.94) with 3+ years of industry experience spanning pharmaceutical LIMS platforms, spatial transcriptomics, and de novo protein design. Currently building agentic multi-omics AI systems at Solid Biosciences and supporting 10,000+ researchers on HPC infrastructure at Northeastern's Research Computing Team.

I bridge the gap between wet-lab biology and production-grade AI/ML — from designing AAV capsid proteins with RFdiffusion3 to deploying full-stack bioinformatics platforms on AWS.


💼 Where I've Worked

Company Role Impact
Solid Biosciences Computational Biology Co-op Agentic multi-omics AI · 50,000+ AAV capsid variants · 80% manual analysis reduction
Boehringer Ingelheim Digital Transformation Intern LLM-powered insight engine · 1M+ cells processed · 40% efficiency gain
Northeastern University Graduate Research Assistant HPC support for 10,000+ researchers across SLURM, GPU, MPI clusters
Lee Makowski Lab Programming Assistant 92% protein gel classification accuracy · AlphaFold3 on HPC
Zifo Technologies Scientific Application Analyst 4+ GxP-compliant LIMS/ELN platforms · 3,500+ pharma users

🔬 What I Build

Protein Design & Structure Prediction AlphaFold3 RFdiffusion3 RoseTTAFold3 Chai-1 Boltz-2 ProteinMPNN LigandMPNN ThermoMPNN ColabFold PyMOL ChimeraX

Genomics & Single-Cell Analysis Scanpy Squidpy Seurat CellRanger Harmony Scanorama CellTypist GATK DESeq2 STAR BWA Nextflow Snakemake

AI/ML & LLM Engineering LangChain RAG FAISS Graph Neural Networks Vision Transformers PyTorch TensorFlow scikit-learn XGBoost Apache Spark

Cloud & MLOps AWS (EC2, S3, Batch, ECR, EFS, SageMaker, Bedrock, RDS, CloudWatch) Azure GCP Docker Singularity SLURM HPC Airflow CI/CD

Full-Stack Development Django React Node.js TypeScript PostgreSQL MongoDB REST APIs


📌 Featured Projects

🧬 Agentic Multi-Omics AI System (Solid Biosciences) LangChain + GPT-4 + AWS SageMaker pipeline processing 500,000+ biomarker measurements for precision medicine target identification.

💊 AAV Capsid Protein Design Platform Cloud-native platform containerizing 11 protein design models (RFdiffusion3, Chai-1, Boltz-2, etc.) with auto-scaling GPU orchestration across 50,000+ de novo DMD variants.

🔍 Single-Cell & Spatial Transcriptomics Platform (Boehringer Ingelheim) End-to-end platform processing 1M+ cells with Scanpy, Squidpy, Harmony, and LLM-powered natural language querying via AWS Bedrock RAG.

✂️ CRISPR-Cas9 ML Optimization Random Forest + Gradient Boosting + Neural Network pipeline predicting sgRNA efficiency from 100,000+ sequences with 92% accuracy, reducing screening by 90%.


📊 GitHub Stats


📄 Publications

  • Emberling et al. (2025) — Metabolic enzymes moonlighting as RNA binding proteins. Biophysical Journal. DOI
  • Apoorvha, Brindha, Ganesan et al. (2025) — Weighted gene co-expression network analysis reveals hub genes of quiescence. 3 Biotech. DOI

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