Bastián Herrera & Daniel Hurtado, @comp-medicine-uc
Computational simulations of microscale pulmonary perfusion and O
Pulmonary capillary perfusion and gas exchange are the fundamental physical processes that enable respiration to occur at the microscale. Present-day computational simulations of these phenomena are often based on low-dimensional mathematical models on idealized alveolar geometries, where the chemical reactions between O
manuscript
: Latest version of the article.raw-data
: Raw images and sources for pulmonary RVE simulations.results-data
: Numerical simulation results.src
: Python and MATLAB source files.tests
: Main files that implement examples and tests.
We now present the main results of this article. Single-capillary perfusion and gas exchange in a simple slab-like domain are shown below.
We performed sensitivity analysis of gas exchange dynamics, varying the inlet blood velocity
We developed a meshing algorithm to reconstruct lung RVEs of
In these geometries, we now perform numerical simulations microscale perfusion and gas exchange.
Finally, we extrapolate our microscale results to the whole-lung, and calculate total lung diffusing capacities for O
Source code is written and runs in Python 3.12 and in MATLAB R2023a. The following libraries are employed: