GTF2A1

Subunidad 1 del factor iniciador de la transcripción IIA
	; Estructura tridimensional de la proteína GTF2A1.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1nvp
Identificadores
Símbolos	GTF2A1 (HGNC: 4646) MGC129969, MGC129970, TF2A1, TFIIA
Identificadores; externos	OMIM: 600520 ; EBI: GTF2A1; GeneCards: Gen GTF2A1; UniProt: GTF2A1;
Locus	Cr. 14 q31.1
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
2957
P52655	n/a
NP_056943	n/a
	v; t; e;
	[editar datos en Wikidata]

La subunidad 1 del factor iniciador de la transcripción IIA (GTF2A1) es una proteína codificada en humanos por el gen gtf2A1.^[1]^[2]

Interacciones

La proteína GTF2A1 ha demostrado ser capaz de interaccionar con:

Véase también

Factor de transcripción II A

Referencias

↑ DeJong J, Roeder RG (Dec de 1993). «A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA». Genes Dev 7 (11): 2220-34. PMID 8224848.
↑ «Entrez Gene: GTF2A1 general transcription factor IIA, 1, 19/37kDa».
↑ DeJong, J; Bernstein R, Roeder R G (Apr. de 1995). «Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (8): 3313-7. ISSN 0027-8424. PMID 7724559.
↑ Langelier, M F; Forget D, Rojas A, Porlier Y, Burton Z F, Coulombe B (Oct. de 2001). «Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II». J. Biol. Chem. (United States) 276 (42): 38652-7. ISSN 0021-9258. PMID 11509574. doi:10.1074/jbc.M106422200.
↑ Ozer, J; Mitsouras K, Zerby D, Carey M, Lieberman P M (Jun. de 1998). «Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding». J. Biol. Chem. (UNITED STATES) 273 (23): 14293-300. ISSN 0021-9258. PMID 9603936.
↑ Solow, S; Salunek M, Ryan R, Lieberman P M (mayo. de 2001). «Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity». J. Biol. Chem. (United States) 276 (19): 15886-92. ISSN 0021-9258. PMID 11278496. doi:10.1074/jbc.M009385200.
↑ Sun, X; Ma D; Sheldon M; Yeung K; Reinberg D (Oct. de 1994). «Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription». Genes Dev. (UNITED STATES) 8 (19): 2336-48. ISSN 0890-9369. PMID 7958900.
↑ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Mol. Syst. Biol. (England) 3: 89. PMID 17353931. doi:10.1038/msb4100134.
↑ Teichmann, M; Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait B T, Roeder R G (Nov. de 1999). «Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (24): 13720-5. ISSN 0027-8424. PMID 10570139.

Enlaces externos

MeSH: GTF2A1+protein,+human (en inglés)

Datos: Q18026610

[pmid8224848-1] DeJong J, Roeder RG (Dec de 1993). «A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA». Genes Dev 7 (11): 2220-34. PMID 8224848.

[entrez-2] «Entrez Gene: GTF2A1 general transcription factor IIA, 1, 19/37kDa».

[pmid7724559-3] DeJong, J; Bernstein R, Roeder R G (Apr. de 1995). «Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (8): 3313-7. ISSN 0027-8424. PMID 7724559.

[pmid11509574-4] Langelier, M F; Forget D, Rojas A, Porlier Y, Burton Z F, Coulombe B (Oct. de 2001). «Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II». J. Biol. Chem. (United States) 276 (42): 38652-7. ISSN 0021-9258. PMID 11509574. doi:10.1074/jbc.M106422200.

[pmid9603936-5] Ozer, J; Mitsouras K, Zerby D, Carey M, Lieberman P M (Jun. de 1998). «Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding». J. Biol. Chem. (UNITED STATES) 273 (23): 14293-300. ISSN 0021-9258. PMID 9603936.

[pmid11278496-6] Solow, S; Salunek M, Ryan R, Lieberman P M (mayo. de 2001). «Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity». J. Biol. Chem. (United States) 276 (19): 15886-92. ISSN 0021-9258. PMID 11278496. doi:10.1074/jbc.M009385200.

[pmid7958900-7] Sun, X; Ma D; Sheldon M; Yeung K; Reinberg D (Oct. de 1994). «Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription». Genes Dev. (UNITED STATES) 8 (19): 2336-48. ISSN 0890-9369. PMID 7958900.

[pmid17353931-8] Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Mol. Syst. Biol. (England) 3: 89. PMID 17353931. doi:10.1038/msb4100134.

[pmid10570139-9] Teichmann, M; Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait B T, Roeder R G (Nov. de 1999). «Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (24): 13720-5. ISSN 0027-8424. PMID 10570139.

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