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Paul Offit

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Paul Offit
grey-haired white male leaning on podium and smiling at camera
Offit in 2011
Born
Paul Allan Offit

(1951-03-27) March 27, 1951 (age 73)[1]
Baltimore, Maryland, U.S.[2]
EducationTufts University (BA)
University of Maryland, Baltimore (MD)
Known forDeveloping a rotavirus vaccine, public advocacy for vaccines
Medical career
ProfessionPediatrician and infectious disease doctor
InstitutionsPerelman School of Medicine at the University of Pennsylvania
Sub-specialtiesVaccinology
Awards
Paul Offit's voice
recorded October 2016
Websitewww.paul-offit.com

Paul Allan Offit (born March 27, 1951) is an American pediatrician specializing in infectious diseases, vaccines, immunology, and virology. He is the co-inventor of a rotavirus vaccine. Offit is the Maurice R. Hilleman Professor of Vaccinology, professor of pediatrics at the Perelman School of Medicine at the University of Pennsylvania, former chief of the Division of Infectious Diseases (1992–2014), and the director of the Vaccine Education Center at the Children's Hospital of Philadelphia.

Offit is a member of the Food and Drug Administration (FDA) Vaccines and Related Biological Products Advisory Committee;[3] a board member of Every Child By Two;[4] a founding board member of the Autism Science Foundation (ASF); [5] and a former member of the Centers for Disease Control (CDC) Advisory Committee on Immunization Practices.[6]

Offit has published more than 130 papers in medical and scientific journals in the areas of rotavirus-specific immune responses and vaccine safety,[7] and is the author or co-author of books on vaccines, vaccination, the rejection of medicine by some religious groups,[8] and antibiotics. He is one of the most public faces of the scientific consensus that vaccines have no association with autism. As a result, he has been the frequent target of hate mail and death threats.[7][9][10]

In 2023, he was elected to the American Philosophical Society.[11]

Life

[edit]

Offit grew up in Baltimore, the son of a shirtmaker. He went to his father's sales meetings and reacted negatively to the tall tales told by salespeople, instead preferring the clean and straightforward practice of science.[12] When he was five years old, he was sent to a polio ward to recover from clubfoot surgery; this experience caused him to see children as vulnerable and helpless, and motivated him through the 25 years of the development of the rotavirus vaccine.[7][13]

Offit decided to become a doctor, the first in his family.[14] Offit earned his bachelor's degree from Tufts University and his M.D. from the University of Maryland, Baltimore. In 1980, he completed his residency training in Pediatrics at Children's Hospital of Pittsburgh.[15][16] That year, he began a fellowship in infectious diseases at Children's Hospital of Philadelphia.[16] One of his mentors was Maurice Hilleman, who developed many of the major vaccines in use today.[12]

In 1990, Offit married Bonnie Fass-Offit, who is also a pediatrician.[17] They had two children.[18]

By 2008 Offit had become a leading advocate of childhood immunizations. He was opposed by vaccine critics, many of whom believe vaccines cause autism, a belief that has been rejected by major medical journals and professional societies.[19][20][21] He received a death threat and received protection by an armed guard during meetings at the CDC.[7] His 2008 book Autism's False Prophets catalyzed a backlash against the antivaccine movement in the U.S.[9] He donated the royalties from the book to the Center for Autism Research at Children's Hospital of Philadelphia.[22] Offit served on the board of the American Council on Science and Health until 2015 when he resigned from the group, accusing them of crossing the line for their promotion of e-cigarettes.[23] In 2015, Offit appeared in a vaccine awareness video created by Robert Till in which he advocated teenage vaccinations.[24]

Rotavirus vaccine

[edit]
Main article: Rotavirus vaccine
Paul Offit (right) along with H. Fred Clark. Clark and Offit are two of the three inventors of the rotavirus vaccine RotaTeq,[14] which is credited with saving hundreds of lives each day.[7]

Offit worked for 25 years on the development of a safe and effective vaccine against rotavirus, which is a cause of diarrhea,[10] and which kills almost 600,000 children a year worldwide, about half as many as malaria kills; most deaths are outside the West.[9] His interest in the disease stemmed from the death of a 9-month-old infant from rotavirus-caused dehydration while under his care as a pediatric resident in 1979.[10][13]

Along with his colleagues Fred Clark and Stanley Plotkin, Offit invented RotaTeq,[14] a pentavalent rotavirus vaccine manufactured by Merck & Co. Since 2006, RotaTeq has been one of two vaccines currently used against rotavirus.[25]

In February 2006, RotaTeq was approved for inclusion in the recommended U.S. vaccination schedule, following its approval by the FDA.[25][26] Premarketing studies found that RotaTeq was effective and safe, with an incidence of adverse events comparable to placebo.[27] RotaTeq has been credited (by Peter Hotez) with saving hundreds of lives a day.[7] Offit received an unspecified sum of money for his interest in RotaTeq.[12] Offit was elected a fellow of the Committee for Skeptical Inquiry, in 2015.[28]

Smallpox vaccine

[edit]

In 2002, during a period of fears about bioterrorism, Offit was the only member of the CDC's advisory panel to vote against a program to give smallpox vaccine to tens of thousands of Americans. He later argued on 60 Minutes II and The NewsHour with Jim Lehrer that the risk of harm for people getting the vaccine outweighed the risk of getting smallpox in the U.S. at the time.[14]

Action against dietary supplements and alternative medicine

[edit]

In December 2013, Sarah Erush and Offit declared the Children's Hospital of Philadelphia has a moratorium on the use of dietary supplements without certain manufacturers' guarantee for quality.[29]

Our hospital has acted to protect the safety of our patients. No longer will we administer dietary supplements unless the manufacturer provides a third-party written guarantee that the product is made under the F.D.A.’s “good manufacturing practice” (G.M.P.) conditions, as well as a Certificate of Analysis (C.O.A.) assuring that what is written on the label is what’s in the bottle.

Offit defines alternative medicine as quackery when it involves unappreciated harm and replacement of conventional therapies that work, with alternative therapies that do not. His books and articles warn against the expense and risk to health for recipients of alternative therapies. In 2013 he wrote the book Do you believe in Magic? – The Sense and Nonsense of Alternative Medicine.[30] Offit states that the purpose of the book "is to take a critical look at the field of Alternative Medicine – to separate fact from myth" and that "There's only medicine that works and medicine that doesn't."(p. 6) One of Offit's concerns is the scare tactics he says proponents of alternative medicine will often use, in a 2010 podcast with the Point of Inquiry Offit stated "it is very difficult to unscare people when you scare them."[31]

Offit has said that the Dietary Supplement Health and Education Act of 1994 should be overturned to provide proper oversight and action against supplement providers.[32]

Reception

[edit]
Offit at CSICon 2018

Offit is a recipient of numerous awards, including the J. Edmund Bradley Prize for Excellence in Pediatrics from the University of Maryland Medical School, the Young Investigator Award in Vaccine Development from the Infectious Diseases Society of America, the 2013 Maxwell Finland Award for Scientific Achievement and a Research Career Development Award from the National Institutes of Health.[22] In 2018, Offit was awarded the Albert B. Sabin Gold Medal from the Sabin Vaccine Institute in Washington, DC for his work on the oral rotavirus vaccine and his leadership in promoting immunization.[33]

In 2011 Offit was honored by the Biotechnology Industry Organization with the 2011 Biotech Humanitarian Award.[34] Offit donated the award's $10,000 prize to the Vaccine Education Center at The Children's Hospital of Philadelphia.[35] Also in 2011, Offit was elected to the Institute of Medicine at the group's annual meeting.[36] In 2013 Offit was presented with the Robert B. Balles Prize in Critical Thinking by the Committee for Skeptical Inquiry (CSI) for Do You Believe in Magic? The Sense and Nonsense of Alternative Medicine. "Offit is a literal lifesaver... educates the public about the dangers of alternative medicine, may save many, many more."[37]

Michael Specter wrote that Offit "has become a figure of hatred to the many vaccine denialists and conspiracy theorists." Specter reported that Offit had often been threatened with violence by anti-vaccine advocates, necessitating precautions such as screening Offit's packages for mail bombs and providing guards when Offit attends federal health advisory committee meetings.[38] At a 2008 vaccine activism rally in Washington, D.C., environmental lawyer Robert F. Kennedy, Jr. criticized Offit's ties to drug companies, calling him a "poster child for the term 'biostitute'."[12] Curt Linderman Sr., the editor of the Autism File blog, wrote online that it would "be nice" if Offit "was dead".[14]

Offit lecture on opioids at CSICon 2016

Such criticism has provoked statements in Offit's defense. Peter Hotez, a professor and vaccine researcher at George Washington University, has been quoted in a Newsweek article:

Peter Hotez ... says government health officials should take a bolder stand in reassuring the public. Hotez feels as strongly as Offit does about the science (saying vaccines cause autism, he says, "is like saying the world is flat"), but, like other busy scientists, he's less willing to enter the fray. "Here's someone who has created an invention that saves hundreds of lives every day," says Hotez, whose daughter, 15, has autism, "and he's vilified as someone who hates children. It's just so unfair."[7]

Publications

[edit]

Offit has written or co-written several books on vaccines, vaccination and the public, and antibiotics, as well as dozens of scholarly articles on the topic. Isabelle Rapin, a neurology professor at the Albert Einstein College of Medicine, wrote in Neurology Today about Autism's False Prophets:

This book explores why parents, seeking in vain for a cure and for an explanation of their child's problem, are so vulnerable to false hopes and to the nasty predators who have from time immemorial always taken advantage of the desperate in our society. ... [Offit] became outraged by Dr. Andrew Wakefield's 1998 study in the Lancet that blamed the measles-mumps-rubella (MMR) vaccine for causing autism. Dr. Offit predicted the paper would precipitate a resurgence of measles and its serious complications, and even deaths – a prophecy soon realized.[39]

In "The Cutter Incident" (see Cutter Laboratories incident), Offit describes fallout relating to an early poliovirus vaccine tragedy that had the effect of deterring production of already licensed vaccines and discouraging the development of new ones. Offit advocates for the repeal of religious exemptions to vaccine requirements, saying that such exemptions amount to medical neglect.[40]

He has also written books on the instances where science generated harmful ideas (Pandora's Lab) and the history of religious opposition (in some groups) to modern medicine (Bad Faith).

In 2021 Offit released You Bet Your Life, which is a history of medical innovations with a particular focus on how some degree of risk is always present in medical innovation.[41]

Books

[edit]
External videos
video icon After Words interview with Offit on You Bet Your Life, November 14, 2021, C-SPAN
  • Offit, Paul A.; Fass-Offit, Bonnie; Bell, Louis M. (1999). Breaking the Antibiotic Habit: A Parent's Guide to Coughs, Colds, Ear Infections, and Sore Throats. John Wiley. ISBN 978-0-471-31982-5.
  • Offit, Paul A.; Bell, Louis M. (1999). Vaccines: What Every Parent Should Know. Macmillan. ISBN 978-0-02-863861-4.
  • UK title: Killing Us Softly: The Sense and Nonsense of Alternative Medicine
  • Offit, Paul A. (2015). Bad Faith: When Religious Belief Undermines Modern Medicine. Basic Books. ISBN 978-0465082964.
  • Offit, Paul A. (2017). Pandora's Lab: Seven Stories of Science Gone Wrong. National Geographic. ISBN 978-1426217982.
  • Offit, Paul A. (2018). Bad Advice: or Why Celebrities, Politicians, and Activists Aren't Your Best Source of Health Information. Columbia University Press. ISBN 978-0231186988.
  • Offit, Paul A. (2020). Overkill: When Modern Medicine Goes Too Far. Harper. ISBN 978-0062947499.[43][44]
  • Offit, Paul (2021). You Bet Your Life: From Blood Transfusions to Mass Vaccination, the Long and Risky History of Medical Innovation. Basic Books. ISBN 978-1541620391.
  • Offit, Paul (2024). Tell Me When It's Over: An Insider's Guide to Deciphering Covid Myths and Navigating Our Post-Pandemic World. National Geographic Partners, LLC. ISBN 978-1-4262-2366-2.

References

[edit]
  1. ^ "Paul A. Offit 1951-". Contemporary Authors. January 1, 2008. Archived from the original on September 24, 2015. Retrieved November 24, 2014.
  2. ^ "Paul A. Offit, MD" (PDF). Archived from the original (PDF) on March 4, 2016. Retrieved November 24, 2014.
  3. ^ "Roster of the Vaccines and Related Biological Products Advisory Committee". fda.gov. Retrieved February 4, 2024.
  4. ^ "Scientific Advisory Board". Every Child by Two. Archived from the original on October 21, 2018. Retrieved March 28, 2016.
  5. ^ "ASF Founding Board Member Dr. Paul Offit Elected to the Institute of Medicine". Autism Science Foundation. October 18, 2011. Retrieved November 10, 2011.
  6. ^ Offit, Paul (2024). Tell Me When It's Over: An Insider's Guide to Deciphering Covid Myths and Navigating Our Post-Pandemic World. Washington D.C.: National Geographic. ISBN 978-1-4262-2366-2.
  7. ^ a b c d e f g Kalb C (November 3, 2008). "Stomping through a medical minefield". Newsweek. 152 (18): 62–3. PMID 18998447.
  8. ^ Offit, Paul (2015). Bad Faith. Basic Books. ISBN 978-1-336-02069-6. OCLC 904084490.
  9. ^ a b c McNeil DG Jr (January 12, 2009). "Book is rallying resistance to the antivaccine crusade". The New York Times. Retrieved January 13, 2009.
  10. ^ a b c Avril T (September 17, 2008). "Expert sees no link between vaccines and autism". The Philadelphia Inquirer.
  11. ^ "The American Philosophical Society Welcomes New Members for 2023".
  12. ^ a b c d Fagone J (June 2009). "Will this doctor hurt your baby?". Philadelphia. Archived from the original on June 8, 2009. Retrieved June 25, 2009.
  13. ^ a b Campbell G (January 30, 2009). "Interview with Dr. Paul Offit, MD, on vaccine safety" (PDF). Books and Ideas. Podcast (MP3). Retrieved 2009-05-13.
  14. ^ a b c d e Wallace A (October 19, 2009). "An epidemic of fear: how panicked parents skipping shots endangers us all". Wired. Retrieved October 21, 2009.
  15. ^ Connelly, Brian (Spring 2011). "Claiming the High Road in the Vaccine Controversy". Pitt Med. Retrieved March 15, 2023.
  16. ^ a b "Paul Offit, MD" (PDF). National Foundation for Infectious Diseases. Retrieved March 15, 2023.
  17. ^ "WEDDINGS/ENGAGEMENTS". Daily Press. October 21, 1990. Retrieved March 15, 2023.
  18. ^ Laughlin, Jason (November 8, 2022). "Paul Offit, Philly's most vocal vaccine advocate, on science, truth, and why he's not a fan of the latest COVID boosters". The Philadelphia Inquirer. Retrieved March 15, 2023.
  19. ^ Boseley, Sarah (February 2, 2010). "Lancet retracts 'utterly false' MMR paper". The Guardian. Retrieved February 2, 2010.
  20. ^ Taylor, Luke E.; Swerdfeger, Amy L.; Eslick, Guy D. (June 2014). "Vaccines are not associated with autism: An evidence-based meta-analysis of case-control and cohort studies". Vaccine. 32 (29): 3623–3629. doi:10.1016/j.vaccine.2014.04.085. PMID 24814559.
  21. ^ Dietrich, Tamara (September 8, 2019). "Doctor takes on the anti-vaccine movement". The Daile Press. Retrieved September 10, 2019.
  22. ^ a b "Author royalties from autism book donated to autism research" (Press release). Children's Hospital of Philadelphia. November 3, 2008.
  23. ^ Lowes, Robert (April 22, 2015). "Group Tied to Dr Oz Critics Has Critics Too". Medscape.
  24. ^ MCIC (November 23, 2015), Teen Vaccine Awareness Video | MCIC, retrieved April 26, 2016
  25. ^ a b McNeil DG Jr (January 5, 2006). "Rotavirus drugs deemed safe and effective". The New York Times. Retrieved October 2, 2008.
  26. ^ Russell S (February 4, 2006). "FDA OKs safer vaccine for children". San Francisco Chronicle. Retrieved October 2, 2008.
  27. ^ American Academy of Pediatrics Committee on Infectious Diseases (2007). "Prevention of rotavirus disease: guidelines for use of rotavirus vaccine". Pediatrics. 119 (1): 171–82. doi:10.1542/peds.2006-3134. PMID 17200286.
  28. ^ "Ten Distinguished Scientists and Scholars Named Fellows of Committee for Skeptical Inquiry - CSI". www.csicop.org. Archived from the original on October 16, 2015. Retrieved October 15, 2015.
  29. ^ Kabat, Geoffrey. "Children's Hospital Of Philadelphia Bans Dietary Supplements From Its Pharmacy". Forbes. Retrieved February 20, 2019.
  30. ^ Offit, Paul A. (2013). Do You Believe in Magic? The Sense and Nonsense of Alternative Medicine. New York: HarperCollins. ISBN 978-0-06-222296-1.
  31. ^ "Paul Offit – The Costs of Vaccine Denialism | Point of Inquiry". www.pointofinquiry.org. February 12, 2010. Retrieved March 28, 2016.
  32. ^ Colanduno, Derek (September 9, 2013). "Do You Believe In Magic? Interview with Paul Offit" (Audio). Skepticality Podcast. Skeptic Magazine. Retrieved December 15, 2013.
  33. ^ Burkholder, Amy (April 26, 2018). "Children's Hospital of Philadelphia's Dr. Paul Offit Receives the 2018 Albert B. Sabin Gold Medal". Children's Hospital of Philadelphia. Archived from the original on May 2, 2018. Retrieved May 2, 2018.
  34. ^ "Home". Archived from the original on March 12, 2016. Retrieved July 1, 2011.
  35. ^ George, John (June 29, 2011). "CHOP doctor who developed rotavirus vaccine honored".
  36. ^ Stencel, Christine (October 17, 2011), IOM Elects 65 New Members, Five Foreign Associates, Institute of Medicine, archived from the original on November 13, 2012, retrieved October 19, 2011
  37. ^ Fidalgo, Paul (July 2014). "CSI Announces Paul Offit As Winner of the 2013 Balles Prize". Skeptical Inquirer. CSICOP. Archived from the original on January 19, 2019. Retrieved August 18, 2016.
  38. ^ Specter, Michael (2009). Denialism: How Irrational Thinking Hinders Scientific Progress, Harms the Planet, and Threatens Our Lives. Penguin Books. ISBN 978-1-59420-230-8.
  39. ^ Rapin I (January 15, 2009). "High Hopes, Shoddy Research and Elusive Therapies for Autism Examined and Exposed". Neurology Today. 9 (2): 23. doi:10.1097/01.NT.0000345037.57123.0b.
  40. ^ Offit, Paul A. (May 10, 2013). "End religious exemption". About Philly.Com. Archived from the original on June 7, 2013. Retrieved December 21, 2013.
  41. ^ Sunstein, Cass R. (September 21, 2021). "A History of Medical Innovation That Doesn't Ignore the Side Effects". The New York Times. ISSN 0362-4331. Retrieved September 25, 2021.
  42. ^ "Review of Deadly Choices: How the Anti-Vaccine Movement Threatens Us All by Paul A. Offit". December 2010.
  43. ^ Hall, Harriet (November 17, 2020). "Review of Overkill: When Modern Medicine Goes Too Far by Paul A. Offit". Science-Based Medicine (sciencebasedmedicine.org).
  44. ^ "Review of Overkill: When Modern Medicine Goes Too Far by Paul A. Offit". Kirkus Reviews. March 2020.
[edit]

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