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Neuropsychiatry

From Wikipedia, the free encyclopedia
For the journal, see Neuropsychiatry (journal).
X-ray image of deep brain stimulation, an experimental procedure used to treat disorders such as OCD and depression.

Neuropsychiatry is a branch of medicine that deals with psychiatry as it relates to neurology, in an effort to understand and attribute behavior to the interaction of neurobiology and social psychology factors.[1] Within neuropsychiatry, the mind is considered "as an emergent property of the brain",[2] whereas other behavioral and neurological specialties might consider the two as separate entities.[3] Those disciplines are typically practiced separately.

Currently, neuropsychiatry has become a growing subspecialty of psychiatry as it closely relates the fields of neuropsychology and behavioral neurology, and attempts to utilize this understanding to better understand autism, ADHD, Tourette's syndrome, etc.

The case for the rapprochement of neurology and psychiatry

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Given the considerable overlap between these subspecialities, there has been a resurgence of interest and debate relating to neuropsychiatry in academia over the last decade.[3][4][5][6][7] Most of this work argues for a rapprochement of neurology and psychiatry, forming a specialty above and beyond a subspecialty of psychiatry. For example, Professor Joseph B. Martin, former Dean of Harvard Medical School and a neurologist by training, has summarized the argument for reunion: "the separation of the two categories is arbitrary, often influenced by beliefs rather than proven scientific observations. And the fact that the brain and mind are one makes the separation artificial anyway."[4] These points and some of the other major arguments are detailed below.

Mind/brain monism

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Neurologists have focused objectively on organic nervous system pathology, especially of the brain, whereas psychiatrists have laid claim to illnesses of the mind. This antipodal distinction between brain and mind as two different entities has characterized many of the differences between the two specialties. However, it has been argued that this division is fictional; evidence from the last century of research has shown that our mental life has its roots in the brain.[4] Brain and mind have been argued not to be discrete entities but just different ways of looking at the same system.[8] It has been argued that embracing this mind/brain monism may be useful for several reasons. First, rejecting dualism implies that all mentation is biological, which provides a common research framework in which understanding and treatment of mental disorders can be advanced. Second, it mitigates widespread confusion about the legitimacy of mental illness by suggesting that all disorders should have a footprint in the brain.[citation needed]

In sum, a reason for the division between psychiatry and neurology was the distinction between mind or first-person experience and the brain. That this difference is taken to be artificial by proponents of mind/brain monism supports a merge between these specialties.[citation needed]

Causal pluralism

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One of the reasons for the divide is that neurology traditionally looks at the causes of disorders from an "inside-the-skin" perspective (neuropathology, genetics) whereas psychiatry looks at "outside-the-skin" causation (personal, interpersonal, cultural).[7] This dichotomy is argued not to be instructive and authors have argued that it is better conceptualized as two ends of a causal continuum.[7] The benefits of this position are: firstly, understanding of etiology will be enriched, in particular between brain and environment. One example is eating disorders, which have been found to have some neuropathology[9] but also show increased incidence in rural Fijian school girls after exposure to television.[10] Another example is schizophrenia, the risk for which may be considerably reduced in a healthy family environment.[11]

It is also argued that this augmented understanding of etiology will lead to better remediation and rehabilitation strategies through an understanding of the different levels in the causal process where one can intervene. It may be that non-organic interventions, like cognitive behavioral therapy (CBT), better attenuate disorders alone or in conjunction with drugs. Linden's demonstration of how psychotherapy has neurobiological commonalities with pharmacotherapy is a pertinent example of this and is encouraging from a patient perspective as the potentiality for pernicious side effects is decreased while self-efficacy is increased.[12]

In sum, the argument is that an understanding of the mental disorders must not only have a specific knowledge of brain constituents and genetics (inside-the-skin) but also the context (outside-the-skin) in which these parts operate.[13] Only by joining neurology and psychiatry, it is argued, can this nexus be used to reduce human suffering.[citation needed]

Organic basis

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To further sketch psychiatry's history shows a departure from structural neuropathology, relying more upon ideology.[14] One example of this is Tourette syndrome, which Sándor Ferenczi, although never having seen a patient with Tourette syndrome, suggested was the symbolic expression of masturbation caused by sexual repression.[15] However, starting with the efficacy of neuroleptic drugs in attenuating symptoms[16] the syndrome has gained pathophysiological support[17] and is hypothesized to have a genetic basis too, based on its high inheritability.[18] This trend can be seen for many hitherto traditionally psychiatric disorders (see table) and is argued to support reuniting neurology and psychiatry because both are dealing with disorders of the same system.[citation needed]

Linking traditional psychiatric symptoms or disorders to brain structures and genetic abnormalities.
(This table is in not exhaustive but provides some psychodynamic and neurological bases to psychiatric symptoms.)
Psychiatric symptoms Psychodynamic explanation Neural correlates
Depression Overwhelming aggression turned inward, guilt[19] Limbic-cortical dysregulation, monoamine imbalance[20]
Mania Avoidance of pain of the reality principle[21] Prefrontal cortex and hippocampus, anterior cingulate, amygdala[22][23]
Schizophrenia Projection of inner fantasies outwards due to ego disintegration[24][25] NMDA receptor activation in the human prefrontal cortex[26]
Visual hallucination Projection, cold distant mother causing a weak ego[citation needed] Retinogeniculocalcarine tract, ascending brainstem modulatory structures[27]
Auditory hallucination Projection, cold distant mother causing a weak ego[citation needed] Frontotemporal functional connectivity[28]
Obsessive-compulsive disorder Shame regarding a pleasurable childhood experience[29] Frontal-subcortical circuitry, right caudate activity[30][31]
Eating disorder Attempted control of internal anxiety[citation needed] Atypical serotonin system, right frontal and temporal lobe dysfunction, changes to mesolimbic dopamine pathways[9] [32]

Improved patient care

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Further, it is argued[by whom?] that this nexus will allow a more refined nosology of mental illness to emerge thus helping to improve remediation and rehabilitation strategies beyond current ones that lump together ranges of symptoms. However, it cuts both ways: traditionally neurological disorders, like Parkinson's disease, are being recognized for their high incidence of traditionally psychiatric symptoms, like psychosis and depression.[33] These symptoms, which are largely ignored in neurology,[3] can be addressed by neuropsychiatry and lead to improved patient care. In sum, it is argued that patients from both traditional psychiatry and neurology departments will see their care improved following a reuniting of the specialties.

Better management model

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Psychiatrist Randolph B. Schiffer, pediatrician Daniel L. Hurst, neuropsychiatrtist Walter Lajara-Nanson, and psychiatrrist Russell C. Packard argue that there are good management and financial reasons for rapprochement.[34][clarification needed]

Theory and focus

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Clinical methods and research

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Treatment

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History

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US institutions

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"Behavioral Neurology & Neuropsychiatry" fellowships are accredited by the United Council for Neurologic Subspecialties (UCNS; www.ucns.org), in a manner analogous to the accreditation of psychiatry and neurology residencies in the United States by the American Board of Psychiatry and Neurology (ABPN).

The American Neuropsychiatric Association (ANPA) was established in 1988 and is the American medical subspecialty society for neuropsychiatrists. ANPA holds an annual meeting and offers other forums for education and professional networking amongst subspecialists in behavioral neurology and neuropsychiatry as well as clinicians, scientists, and educators in related fields. American Psychiatric Publishing, Inc. publishes the peer-reviewed Journal of Neuropsychiatry and Clinical Neurosciences, which is the official journal of ANPA.

International organizations

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The International Neuropsychiatric Association was established in 1996.[35] INA holds congresses biennially in countries around the world and partners with regional neuropsychiatric associations around the world to support regional neuropsychiatric conferences and to facilitate the development of neuropsychiatry in the countries/regions where those conferences are held. Prof. Robert Haim Belmaker[36] is the current president of the organization whereas Prof. Ennapadam S Krishnamoorthy[37] serves as President-Elect with Dr. Gilberto Brofman as Secretary-Treasurer.[38]

The British NeuroPsychiatry Association (BNPA) was founded in 1987[39] and is the leading academic and professional body for medical practitioners and professionals allied to medicine in the UK working at the interface of the clinical and cognitive neurosciences and psychiatry.

In 2011, a non-profit professional society named Neuropsychiatric Forum (NPF) was founded. NPF aims to support effective communication and interdisciplinary collaboration, develop education schemes and research projects, organize neuropsychiatric conferences and seminars.

Criticism

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Main article: Anti-psychiatry

Fernando Vidal and Francisco Ortega argue that neuropsychiatry strengthens the conception of mental suffering as a product of individual irresponsibility.[40] In his book Capitalist Realism, academic Mark Fisher in turn states that when depression is made to be a consequence of individual biochemial imbalance, social causation is ruled out.[41]

Historian Edward Shorter argues that the view that depression is a brain disorder to be corrected with medication is a product of the pharmaceutical advertising rather than a scientific understanding of depression.[42]

The efficacy of neuropsychiatric treatment has been questioned. This is particularly in regard to psychiatric drugs, of which the success of and mechanism of treatment is mixed and largely unknown respectively,[43] and the use of current neuroimaging technology for diagnostic and treatment purposes, which according to neuropsychiatrist Helen S. Mayberg is "without medical or scientific support,”[44] as results do not clarify causality.[45]

See also

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References

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  1. ^ Sachdev, Perminder S. (May 2005). "Whither Neuropsychiatry?". The Journal of Neuropsychiatry and Clinical Neurosciences. 17 (2): 140–141. doi:10.1176/jnp.17.2.140. ISSN 0895-0172. PMID 15939966.
  2. ^ Sachdev, Perminder S.; Mohan, Adith (2013). "Neuropsychiatry: Where Are We And Where Do We Go From Here?". Mens Sana Monographs. 11 (1): 4–15. doi:10.4103/0973-1229.109282 (inactive 1 November 2024). ISSN 0973-1229. PMC 3653233. PMID 23678234.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
  3. ^ a b c Yudofsky, S.C.; Hales, E.H. (2002). "Neuropsychiatry and the Future of Psychiatry and Neurology". American Journal of Psychiatry. 159 (8): 1261–1264. doi:10.1176/appi.ajp.159.8.1261. PMID 12153815.
  4. ^ a b c Martin, J.B. (2002). "The integration of neurology, psychiatry, and neuroscience in the 21st century". American Journal of Psychiatry. 159 (5): 695–704. doi:10.1176/appi.ajp.159.5.695. PMID 11986119.
  5. ^ Berrios, G.E.; Marková, I.S. (2002). "The concept of neuropsychiatry: a historical overview". Journal of Psychosomatic Research. 53 (2): 629–638. doi:10.1016/s0022-3999(02)00427-0. PMID 12169337.
  6. ^ Price, B.H.; Adams, R.D.; Coyle, J.T. (2000). "Neurology and psychiatry: Closing the great divide". Neurology. 54 (1): 8–14. doi:10.1212/wnl.54.1.8. PMID 10636118. S2CID 19841796.
  7. ^ a b c Kendler, K.S. (2005). "Toward a Philosophical Structure for Psychiatry". American Journal of Psychiatry. 162 (3): 433–440. doi:10.1176/appi.ajp.162.3.433. PMID 15741457.
  8. ^ Marr, David (2010). Vision: a computational investigation into the human representation and processing of visual information. Cambridge, Mass: MIT Press. ISBN 978-0-262-51462-0. OCLC 472791457.
  9. ^ a b Uher, R.; Treasure, J. (2005-06-01). "Brain lesions and eating disorders". Journal of Neurology, Neurosurgery & Psychiatry. 76 (6): 852–857. doi:10.1136/jnnp.2004.048819. ISSN 0022-3050. PMC 1739667. PMID 15897510.
  10. ^ Becker, Anne E. (December 2004). "Television, Disordered Eating, and Young Women in Fiji: Negotiating Body Image and Identity during Rapid Social Change". Culture, Medicine and Psychiatry. 28 (4): 533–559. doi:10.1007/s11013-004-1067-5. ISSN 0165-005X.
  11. ^ Tienari, Pekka; Wynne, Lyman C.; Sorri, Anneli; Lahti, Ilpo; Läksy, Kristian; Moring, Juha; Naarala, Mikko; Nieminen, Pentti; Wahlberg, Karl-Erik (March 2004). "Genotype–environment interaction in schizophrenia-spectrum disorder: Long-term follow-up study of Finnish adoptees". British Journal of Psychiatry. 184 (3): 216–222. doi:10.1192/bjp.184.3.216. ISSN 0007-1250.
  12. ^ Linden, D E J (2006-06-01). "How psychotherapy changes the brain – the contribution of functional neuroimaging". Molecular Psychiatry. 11 (6): 528–538. doi:10.1038/sj.mp.4001816. ISSN 1359-4184.
  13. ^ Koch, Christof; Laurent, Gilles (1999-04-02). "Complexity and the Nervous System". Science. 284 (5411): 96–98. doi:10.1126/science.284.5411.96. ISSN 0036-8075.
  14. ^ "Turning points in twentieth-century American psychiatry". American Journal of Psychiatry. 147 (10): 1267–1274. October 1990. doi:10.1176/ajp.147.10.1267. ISSN 0002-953X.
  15. ^ Ferenczi, Sándor (1921). "Psycho-Analytical Observations on Tic". The International Journal of Psychoanalysis. 2: 1–30 – via PEP.
  16. ^ Shapiro, Arthur K.; Shapiro, Elaine; Wayne, Henriette; Clarkin, John (June 1973). "Organic Factors in Gilles de la Tourette's Syndrome". British Journal of Psychiatry. 122 (571): 659–664. doi:10.1192/bjp.122.6.659. ISSN 0007-1250.
  17. ^ Singer, Harvey S. (1997-05-01). "Neurobiology of Tourette Syndrome". Neurologic Clinics. 15 (2): 357–379. doi:10.1016/S0733-8619(05)70318-2. ISSN 0733-8619.
  18. ^ Robertson, M. M. (2000-03-01). "Tourette syndrome, associated conditions and the complexities of treatment". Brain. 123 (3): 425–462. doi:10.1093/brain/123.3.425.
  19. ^ Ribeiro, Ângela; Ribeiro, João P.; von Doellinger, Orlando (2018). "Depression and psychodynamic psychotherapy". Revista Brasileira De Psiquiatria (Sao Paulo, Brazil: 1999). 40 (1): 105–109. doi:10.1590/1516-4446-2016-2107. ISSN 1809-452X. PMC 6899418. PMID 28614491.
  20. ^ "Limbic-cortical dysregulation: a proposed model of depression". The Journal of Neuropsychiatry and Clinical Neurosciences. 9 (3): 471–481. 1997-08-01. doi:10.1176/jnp.9.3.471. ISSN 0895-0172.
  21. ^ Widakowich, Christian (2015). "[THE MANIC DEPRESSIVE DISEASE: PSYCHODYNAMICS ASPECTS AND AFFECTIVE SYNTONY]". Vertex (Buenos Aires, Argentina). 26 (119): 28–33. ISSN 0327-6139. PMID 26323110.
  22. ^ Barrett, T. B.; Hauger, R. L.; Kennedy, J. L.; Sadovnick, A. D.; Remick, R. A.; Keck, P. E.; McElroy, S. L.; Alexander, M.; Shaw, S. H.; Kelsoe, J. R. (May 2003). "Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder". Molecular Psychiatry. 8 (5): 546–557. doi:10.1038/sj.mp.4001268. ISSN 1476-5578.
  23. ^ Vawter, Marquis P; Freed, William J; Kleinman, Joel E (September 2000). "Neuropathology of bipolar disorder". Biological Psychiatry. 48 (6): 486–504. doi:10.1016/S0006-3223(00)00978-1.
  24. ^ "Schizophrenia From the Psychodynamic Perspective". Psychiatric Times. 2023-02-17. Retrieved 2024-11-27.
  25. ^ Rupani, Karishma; Sousa, Avinash De (2017-06-03). "Psychodynamic Theories Of Schizophrenia – Revisited" (PDF). Indian Journal of Mental Health(IJMH). 4 (1): 06. doi:10.30877/IJMH.4.1.2017.6-15. ISSN 2394-6652.
  26. ^ Ross, Christopher A.; Margolis, Russell L.; Reading, Sarah A.J.; Pletnikov, Mikhail; Coyle, Joseph T. (October 2006). "Neurobiology of Schizophrenia". Neuron. 52 (1): 139–153. doi:10.1016/j.neuron.2006.09.015.
  27. ^ Mocellin, Ramon; Walterfang, Mark; Velakoulis, Dennis (September 2006). "Neuropsychiatry of Complex Visual Hallucinations". Australian & New Zealand Journal of Psychiatry. 40 (9): 742–751. doi:10.1080/j.1440-1614.2006.01878.x. ISSN 0004-8674.
  28. ^ Shergill, Sukhwinder S.; Brammer, Michael J.; Williams, Steven C. R.; Murray, Robin M.; McGuire, Philip K. (2000-11-01). "Mapping Auditory Hallucinations in Schizophrenia Using Functional Magnetic Resonance Imaging". Archives of General Psychiatry. 57 (11): 1033. doi:10.1001/archpsyc.57.11.1033. ISSN 0003-990X.
  29. ^ Barth, F. D. (1990). "Obsessional thinking as "paradoxical action"". Bulletin of the Menninger Clinic. 54 (4): 499–511. ISSN 0025-9284. PMID 2268756.
  30. ^ Saxena, S.; Brody, A. L.; Schwartz, J. M.; Baxter, L. R. (August 1998). "Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder". The British Journal of Psychiatry. 173 (S35): 26–37. doi:10.1192/S0007125000297870. ISSN 0007-1250.
  31. ^ Gamazo-Garrán, Pilar; Soutullo, Cesar A.; Ortuño, Felipe (September 2002). "Obsessive-Compulsive Disorder Secondary to Brain Dysgerminoma in an Adolescent Boy: A Positron Emission Tomography Case Report". Journal of Child and Adolescent Psychopharmacology. 12 (3): 259–263. doi:10.1089/104454602760386950. ISSN 1044-5463.
  32. ^ Kaye, W; Frank, G; Bailer, U; Henry, S; Meltzer, C; Price, J; Mathis, C; Wagner, A (2005-05-19). "Serotonin alterations in anorexia and bulimia nervosa: New insights from imaging studies". Physiology & Behavior. 85 (1): 73–81. doi:10.1016/j.physbeh.2005.04.013.
  33. ^ Lerner, A.; Whitehouse, P. (2002). "Neuropsychiatric aspects of dementias associated with motor dysfunction". {{cite journal}}: Cite journal requires |journal= (help)
  34. ^ Schiffer, Randolph B.; Bowen, Beverly; Hinderliter, Josie; Hurst, Daniel L.; Lajara-Nanson, Walter A.; Packard, Russell C. (August 2004). "Neuropsychiatry: A Management Model for Academic Medicine". The Journal of Neuropsychiatry and Clinical Neurosciences. 16 (3): 336–341. doi:10.1176/jnp.16.3.336. ISSN 0895-0172.
  35. ^ "International Neuropsychiatric Association". Official Website.
  36. ^ "אתר הבית של פרופ' חיים בלמקר". haimbelmaker.co.il. Retrieved 2017-01-25.
  37. ^ "Neurokrish - The Neuropsychiatry Center".
  38. ^ "International Neuropsychiatric Association". Committee Members.
  39. ^ "Bulletin Of The Royal College Of Psychiatrists" (PDF).
  40. ^ Vidal, Fernando; Ortega, Francisco (2017). Geroulanos, Stefanos; Meyers, Todd (eds.). Being Brains: Making the Cerebral Subject. Fordham University Press. doi:10.2307/j.ctt1xhr6bn.6. ISBN 978-0-8232-7607-3.
  41. ^ Fisher, Mark (2009). Capitalist realism: is there no alternative?. Zero books. Winchester, UK Washington, USA: Zero Books. ISBN 978-1-84694-317-1.
  42. ^ Shorter, Edward (1997). A history of psychiatry: from the era of the asylum to the age of Prozac. New York Weinheim: Wiley. ISBN 978-0-471-24531-5.
  43. ^ Penn, Elizabeth; Tracy, Derek K. (2012-10). "The drugs don't work? antidepressants and the current and future pharmacological management of depression". Therapeutic Advances in Psychopharmacology. 2 (5): 179–188. doi:10.1177/2045125312445469. ISSN 2045-1253. PMC 3736946. PMID 23983973. {{cite journal}}: Check date values in: |date= (help)
  44. ^ Akhigbe, A. O.; Akhigbe, K. O. (2015). "Neuroimaging in Psychiatry: A Review of the Background and Current Trends" (PDF). Nigerian Journal of Psychiatry. 13 (1).
  45. ^ Rose, Nikolas S.; Abi-Rached, Joelle M. (2013). Neuro: the new brain sciences and the management of the mind. Princeton, N.J: Princeton University Press. ISBN 978-0-691-14960-8.
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Journals

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International/national organizations

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