GPM6A

GPM6A
Identifiers
Aliases	GPM6A, GPM6, M6A, glycoprotein M6A
External IDs	OMIM: 601275; MGI: 107671; HomoloGene: 3864; GeneCards: GPM6A; OMA:GPM6A - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	176,002,664 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	55,513,906 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; entorhinal cortex; ; superior frontal gyrus; ; orbitofrontal cortex; ; Region I of hippocampus proper; ; postcentral gyrus; ; primary visual cortex; ; middle temporal gyrus; ; paraflocculus of cerebellum;
	Top expressed in
	subiculum; ; piriform cortex; ; anterior amygdaloid area; ; Region I of hippocampus proper; ; lobe of cerebellum; ; primary motor cortex; ; cingulate gyrus; ; lateral septal nucleus; ; cerebellar vermis; ; prefrontal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium channel activity; protein binding;
Cellular component	integral component of membrane; extracellular vesicle; cell projection; membrane; filopodium; plasma membrane; dendritic spine; axonal growth cone; axon; soma; neuron projection; extracellular exosome; glutamatergic synapse; integral component of presynaptic active zone membrane;
Biological process	neuron projection morphogenesis; neuron migration; stem cell differentiation; nervous system development; calcium ion transmembrane transport; synapse assembly; positive regulation of filopodium assembly; neural retina development; response to bacterium; neuron projection development; regulation of synapse organization;
	Sources:Amigo / QuickGO
Orthologs
	2823
	234267
	ENSG00000150625
	ENSMUSG00000031517
	P51674
	P35802
NM_001261447; NM_001261448; NM_005277; NM_201591; NM_201592;
	NM_001388090; NM_001388091
	NM_001253754; NM_001253756; NM_153581
	NP_001248376; NP_001248377; NP_005268; NP_963885; NP_963886
	NP_001240683; NP_001240685; NP_705809
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal membrane glycoprotein M6-a is a protein that in humans is encoded by the GPM6A gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150625 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031517 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, et al. (May 1996). "Chromosomal mapping of the human M6 genes". Genomics. 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID 8661015.
^ Liang YJ, Wu DF, Stumm R, Höllt V, Koch T (July 2008). "Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway". Cell Research. 18 (7): 768–79. doi:10.1038/cr.2008.71. PMID 18574501.
^ "Entrez Gene: GPM6A glycoprotein M6A".

Boks MP, Hoogendoorn M, Jungerius BJ, Bakker SC, Sommer IE, Sinke RJ, et al. (September 2008). "Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 147B (6): 707–11. doi:10.1002/ajmg.b.30667. PMID 18163405. S2CID 30736289.
DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". Journal of Proteome Research. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, et al. (February 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". The Journal of Biological Chemistry. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
Mukobata S, Hibino T, Sugiyama A, Urano Y, Inatomi A, Kanai Y, et al. (October 2002). "M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation". Biochemical and Biophysical Research Communications. 297 (4): 722–8. doi:10.1016/S0006-291X(02)02284-2. PMID 12359212.
Shimizu F, Watanabe TK, Fujiwara T, Takahashi E, Nakamura Y, Maekawa H (1996). "Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34". Cytogenetics and Cell Genetics. 74 (1–2): 138–9. doi:10.1159/000134401. PMID 8893821.
Yan Y, Narayanan V, Lagenaur C (July 1996). "Expression of members of the proteolipid protein gene family in the developing murine central nervous system". The Journal of Comparative Neurology. 370 (4): 465–78. doi:10.1002/(SICI)1096-9861(19960708)370:4<465::AID-CNE4>3.0.CO;2-2. PMID 8807448. S2CID 27877672.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150625 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031517 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8661015-5] Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, et al. (May 1996). "Chromosomal mapping of the human M6 genes". Genomics. 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID 8661015.

[pmid18574501-6] Liang YJ, Wu DF, Stumm R, Höllt V, Koch T (July 2008). "Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway". Cell Research. 18 (7): 768–79. doi:10.1038/cr.2008.71. PMID 18574501.

[entrez-7] "Entrez Gene: GPM6A glycoprotein M6A".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t e Protein: nerve tissue protein
Synuclein	Alpha-synuclein Beta-synuclein Gamma-synuclein
Other	Agrin Chimerin Granin Chromogranin A B FMR1 Gap-43 protein GLUT3 Myelin Brain natriuretic peptide Nerve growth factor SCG5 Neurogranin Neuronal calcium sensor Neuropeptide Olfactory marker protein S100 protein Calgranulin Synapsin 1 2 3 Synaptophysin Tubulin GPM6A

References

Further reading