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Daf-9

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Cytochrome P450 daf-9
Identifiers
OrganismCaenorhabditis elegans
Symboldaf-9
Alt. symbolsCYP22A1
Entrez180889
RefSeq (mRNA)NM_001029732.2
RefSeq (Prot)NP_001024903.1
UniProtH2KYS3
Other data
ChromosomeX: 6.2 - 6.2 Mb
Search for
StructuresSwiss-model
DomainsInterPro

The Daf-9 gene encodes a cytochrome p450 enzyme catalysis the generation of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans,[1] with the CYP Symbol CYP22A1 (Cytochrome P450, family 22, member A1). After generation, dafachronic acid will binding it's nuclear receptor Daf-12 and has been implicated by Cynthia Kenyon and colleagues related to the formation of Dauer larva.[2]

References

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  1. ^ Jia K, Albert PS, Riddle DL (2002). "DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity". Development. 129 (1): 221–31. doi:10.1242/dev.129.1.221. PMID 11782415.
  2. ^ Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993). "A C. elegans mutant that lives twice as long as wild type". Nature. 366 (6454): 461–464. Bibcode:1993Natur.366..461K. doi:10.1038/366461a0. PMID 8247153. S2CID 4332206.
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