VAV2

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.

VAV2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ
Identifiers
Aliases	VAV2, VAV-2, vav guanine nucleotide exchange factor 2
External IDs	OMIM: 600428; MGI: 102718; HomoloGene: 2530; GeneCards: VAV2; OMA:VAV2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.2 Start 133,761,894 bp End 133,992,604 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 A3|2 19.36 cM Start 27,152,116 bp End 27,317,045 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland ganglionic eminence ventricular zone body of pancreas right lobe of liver caput epididymis right adrenal cortex corpus epididymis left adrenal cortex jejunal mucosa Top expressed in habenula mesenteric lymph nodes lumbar spinal ganglion medullary collecting duct seminal vesicula cumulus cell seminiferous tubule conjunctival fornix ganglionic eminence molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding metal ion binding protein binding phosphotyrosine residue binding Cellular component cytoplasm cytosol plasma membrane Biological process regulation of cell size intracellular signal transduction Fc-gamma receptor signaling pathway involved in phagocytosis regulation of GTPase activity ephrin receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase activity platelet activation Fc-epsilon receptor signaling pathway vascular endothelial growth factor receptor signaling pathway cell projection assembly angiogenesis positive regulation of apoptotic process regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction cell migration signal transduction lamellipodium assembly small GTPase mediated signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7410 22325 Ensembl ENSG00000160293 ENSMUSG00000009621 UniProt P52735 Q60992 RefSeq (mRNA) NM_001134398 NM_003371 NM_009500 RefSeq (protein) NP_001127870 NP_003362 NP_033526 Location (UCSC) Chr 9: 133.76 – 133.99 Mb Chr 2: 27.15 – 27.32 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.

Interactions

VAV2 is a GEF for RAC1, specifically in fibroblasts VAV2 is necessary for integrin, but not growth factor–dependent activation of RAC leading to lamellipodia formation. Double DH domain mutations, L342R/L343SVav2 function as a dominant negative, blocking VAV2 GEF activity for RAC1 and a PH domain mutant is required for recruitment of VAV2 to the membrane in order to elicit GEF activity. VAV2 has also been shown to regulate collagen phagocytosis in a RAC1-dependent manner and interact with CD19 and Grb2.

Further reading

• Romero F, Fischer S (1997). "Structure and function of vav". Cell. Signal. 8 (8): 545–53. doi:10.1016/S0898-6568(96)00118-0. PMID 9115846.
• Smit L, van der Horst G, Borst J (1996). "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors". J. Biol. Chem. 271 (15): 8564–9. doi:10.1074/jbc.271.15.8564. PMID 8621483.
• Tamma SM, Chirmule N, Yagura H, et al. (1997). "CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells". Blood. 90 (4): 1588–93. doi:10.1182/blood.V90.4.1588. PMID 9269777.
• De Sepulveda P, Okkenhaug K, Rose JL, et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". EMBO J. 18 (4): 904–15. doi:10.1093/emboj/18.4.904. PMC 1171183. PMID 10022833.
• Pandey A, Podtelejnikov AV, Blagoev B, et al. (2000). "Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors". Proc. Natl. Acad. Sci. U.S.A. 97 (1): 179–84. Bibcode:2000PNAS...97..179P. doi:10.1073/pnas.97.1.179. PMC 26636. PMID 10618391.
• Moores SL, Selfors LM, Fredericks J, et al. (2000). "Vav family proteins couple to diverse cell surface receptors". Mol. Cell. Biol. 20 (17): 6364–73. doi:10.1128/MCB.20.17.6364-6373.2000. PMC 86111. PMID 10938113.
• Liu BP, Burridge K (2000). "Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins". Mol. Cell. Biol. 20 (19): 7160–9. doi:10.1128/MCB.20.19.7160-7169.2000. PMC 86269. PMID 10982832.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Doody GM, Billadeau DD, Clayton E, et al. (2001). "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes". EMBO J. 19 (22): 6173–84. doi:10.1093/emboj/19.22.6173. PMC 305817. PMID 11080163.
• Tartare-Deckert S, Monthouel MN, Charvet C, et al. (2001). "Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte". J. Biol. Chem. 276 (24): 20849–57. doi:10.1074/jbc.M010588200. PMID 11262396.
• Teckchandani AM, Feshchenko EA, Tsygankov AY (2001). "c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases". Oncogene. 20 (14): 1739–55. doi:10.1038/sj.onc.1204246. PMID 11313921. S2CID 28410819.
• Jevremovic D, Billadeau DD, Schoon RA, et al. (2001). "Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2". J. Immunol. 166 (12): 7219–28. doi:10.4049/jimmunol.166.12.7219. PMID 11390470.
• Marignani PA, Carpenter CL (2001). "Vav2 is required for cell spreading". J. Cell Biol. 154 (1): 177–86. doi:10.1083/jcb.200103134. PMC 2196856. PMID 11448999.
• Tamás P, Solti Z, Buday L (2001). "Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor". Cell. Signal. 13 (7): 475–81. doi:10.1016/S0898-6568(01)00172-3. PMID 11516622.
• Bourguignon LY, Zhu H, Zhou B, et al. (2002). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. 276 (52): 48679–92. doi:10.1074/jbc.M106759200. PMID 11606575.
• Booden MA, Campbell SL, Der CJ (2002). "Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation". Mol. Cell. Biol. 22 (8): 2487–97. doi:10.1128/MCB.22.8.2487-2497.2002. PMC 133724. PMID 11909943.
• Tamás P, Solti Z, Bauer P, et al. (2003). "Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac". J. Biol. Chem. 278 (7): 5163–71. doi:10.1074/jbc.M207555200. PMID 12454019.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

• Overview of all the structural information available in the PDB for UniProt: P52735 (Guanine nucleotide exchange factor VAV2) at the PDBe-KB.