RALY

RNA-binding protein Raly is a protein that in humans is encoded by the RALY gene.

RALY
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WF1
Identifiers
Aliases	RALY, HNRPCL2, P542, RALY heterogeneous nuclear ribonucleoprotein
External IDs	OMIM: 614663; MGI: 97850; HomoloGene: 7216; GeneCards: RALY; OMA:RALY - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.22 Start 33,993,646 bp End 34,108,308 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 H1|2 76.83 cM Start 154,633,016 bp End 154,709,181 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence granulocyte ventricular zone right lobe of thyroid gland mucosa of transverse colon left lobe of thyroid gland left testis right testis ascending aorta popliteal artery Top expressed in neural layer of retina ventricular zone yolk sac granulocyte lip embryo epiblast tail of embryo embryo thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding transcription coregulator activity RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex nucleus Biological process mRNA splicing, via spliceosome mRNA processing RNA splicing regulation of transcription, DNA-templated transcription, DNA-templated regulation of nucleic acid-templated transcription cholesterol homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22913 19383 Ensembl ENSG00000125970 ENSMUSG00000027593 UniProt Q9UKM9 Q64012 RefSeq (mRNA) NM_007367 NM_016732 NM_001139511 NM_001139512 NM_001139513 NM_023130 RefSeq (protein) NP_031393 NP_057951 NP_001132983 NP_001132984 NP_001132985 NP_075619 Location (UCSC) Chr 20: 33.99 – 34.11 Mb Chr 2: 154.63 – 154.71 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

In infectious mononucleosis, anti-EBNA-1 antibodies are produced which cross-react with multiple normal human proteins. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F (2006). "Phosphoproteomic analysis of the human pituitary". Pituitary. 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684. S2CID 10789246.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Rhodes GH, Valbracht JR, Nguyen MD, Vaughan JH (1997). "The p542 gene encodes an autoantigen that cross-reacts with EBNA-1 of the Epstein Barr virus and which may be a heterogeneous nuclear ribonucleoprotein". J. Autoimmun. 10 (5): 447–54. doi:10.1006/jaut.1997.9996. PMID 9376072.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Vaughan JH, Valbracht JR, Nguyen MD, et al. (1995). "Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1". J. Clin. Invest. 95 (3): 1306–15. doi:10.1172/JCI117781. PMC 441470. PMID 7533788.