PPP5C

Serine/threonine-protein phosphatase 5 is an enzyme that in humans is encoded by the PPP5C gene.

PPP5C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A17, 1S95, 1WAO, 2BUG, 3H60, 3H61, 3H62, 3H63, 3H64, 3H66, 3H67, 3H68, 3H69, 4ZX2, 4ZVZ
Identifiers
Aliases	PPP5C, PP5, PPP5, PPT, protein phosphatase 5 catalytic subunit
External IDs	OMIM: 600658; MGI: 102666; HomoloGene: 4550; GeneCards: PPP5C; OMA:PPP5C - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 46,347,087 bp End 46,392,981 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A2|7 9.15 cM Start 16,738,565 bp End 16,761,849 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube ganglionic eminence anterior pituitary ventricular zone right hemisphere of cerebellum apex of heart stromal cell of endometrium right auricle right frontal lobe right adrenal gland Top expressed in neural layer of retina yolk sac superior frontal gyrus tail of embryo dentate gyrus of hippocampal formation granule cell cerebellar cortex muscle of thigh gastrula epiblast ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity heat shock protein binding microtubule binding ADP binding protein serine/threonine phosphatase activity signal transducer activity metal ion binding protein binding RNA binding identical protein binding G-protein alpha-subunit binding hydrolase activity ATP binding lipid binding Hsp90 protein binding Cellular component perikaryon membrane intracellular membrane-bounded organelle plasma membrane soma proximal dendrite neuron projection nucleus cell periphery nucleoplasm cytoplasm cytosol Biological process negative regulation of protein phosphorylation positive regulation of glucocorticoid receptor signaling pathway protein heterooligomerization protein dephosphorylation negative regulation of cell death cellular response to cadmium ion transcription, DNA-templated MAPK cascade cellular response to DNA damage stimulus response to morphine response to lead ion protein complex oligomerization positive regulation of I-kappaB kinase/NF-kappaB signaling cellular response to hydrogen peroxide negative regulation of neuron death DNA repair mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5536 19060 Ensembl ENSG00000011485 ENSMUSG00000003099 UniProt P53041 Q60676 RefSeq (mRNA) NM_006247 NM_001204284 NM_011155 RefSeq (protein) NP_001191213 NP_006238 NP_035285 Location (UCSC) Chr 19: 46.35 – 46.39 Mb Chr 7: 16.74 – 16.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PPP5C has been shown to interact with ASK1, CRY2 GNA12. and Rac1,

Further reading

• Chen MX, McPartlin AE, Brown L, Chen YH, Barker HM, Cohen PT (Sep 1994). "A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus". The EMBO Journal. 13 (18): 4278–90. doi:10.1002/j.1460-2075.1994.tb06748.x. PMC 395355. PMID 7925273.
• Skinner J, Sinclair C, Romeo C, Armstrong D, Charbonneau H, Rossie S (Sep 1997). "Purification of a fatty acid-stimulated protein-serine/threonine phosphatase from bovine brain and its identification as a homolog of protein phosphatase 5". The Journal of Biological Chemistry. 272 (36): 22464–71. doi:10.1074/jbc.272.36.22464. PMID 9278397.
• Shah BH, Catt KJ (Dec 2006). "Protein phosphatase 5 as a negative key regulator of Raf-1 activation". Trends in Endocrinology and Metabolism. 17 (10): 382–4. doi:10.1016/j.tem.2006.10.013. PMID 17084641. S2CID 45060016.
• Goedert M, Cohen ES, Jakes R, Cohen P (Nov 1992). "p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]". FEBS Letters. 312 (1): 95–9. doi:10.1016/0014-5793(92)81418-L. PMID 1330687. S2CID 34940651.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Xu X, Lagercrantz J, Zickert P, Bajalica-Lagercrantz S, Zetterberg A (Jan 1996). "Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene". Biochemical and Biophysical Research Communications. 218 (2): 514–7. doi:10.1006/bbrc.1996.0092. PMID 8561788.
• Silverstein AM, Galigniana MD, Chen MS, Owens-Grillo JK, Chinkers M, Pratt WB (Jun 1997). "Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin". The Journal of Biological Chemistry. 272 (26): 16224–30. doi:10.1074/jbc.272.26.16224. PMID 9195923.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhao S, Sancar A (Nov 1997). "Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity". Photochemistry and Photobiology. 66 (5): 727–31. doi:10.1111/j.1751-1097.1997.tb03214.x. PMID 9383998. S2CID 32804361.
• Ollendorff V, Donoghue DJ (Dec 1997). "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex". The Journal of Biological Chemistry. 272 (51): 32011–8. doi:10.1074/jbc.272.51.32011. PMID 9405394.
• Das AK, Cohen PW, Barford D (Mar 1998). "The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions". The EMBO Journal. 17 (5): 1192–9. doi:10.1093/emboj/17.5.1192. PMC 1170467. PMID 9482716.
• Russell LC, Whitt SR, Chen MS, Chinkers M (Jul 1999). "Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90". The Journal of Biological Chemistry. 274 (29): 20060–3. doi:10.1074/jbc.274.29.20060. PMID 10400612.
• Lubert EJ, Hong Y, Sarge KD (Oct 2001). "Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5". The Journal of Biological Chemistry. 276 (42): 38582–7. doi:10.1074/jbc.M106906200. PMID 11504734.
• Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov 2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". The EMBO Journal. 20 (21): 6028–36. doi:10.1093/emboj/20.21.6028. PMC 125685. PMID 11689443.
• Sanchez-Ortiz E, Hahm BK, Armstrong DL, Rossie S (Oct 2009). "Protein phosphatase 5 protects neurons against amyloid-beta toxicity". Journal of Neurochemistry. 111 (2): 391–402. doi:10.1111/j.1471-4159.2009.06337.x. PMC 3044491. PMID 19686245.
• Yamaguchi Y, Katoh H, Mori K, Negishi M (Aug 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367. S2CID 11485795.
• Gentile S, Darden T, Erxleben C, Romeo C, Russo A, Martin N, Rossie S, Armstrong DL (Mar 2006). "Rac GTPase signaling through the PP5 protein phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 103 (13): 5202–6. Bibcode:2006PNAS..103.5202G. doi:10.1073/pnas.0600080103. PMC 1458818. PMID 16549782.
• Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX (2003). "Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5". Neuroscience. 115 (3): 829–37. doi:10.1016/S0306-4522(02)00510-9. PMID 12435421. S2CID 26118803.
• Urban G, Golden T, Aragon IV, Cowsert L, Cooper SR, Dean NM, Honkanen RE (Mar 2003). "Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression". The Journal of Biological Chemistry. 278 (11): 9747–53. doi:10.1074/jbc.M210993200. PMID 12519780.
• Tomsig JL, Snyder SL, Creutz CE (Mar 2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". The Journal of Biological Chemistry. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.