Bat influenza is a type of influenza A viruses found in bats.[1] Bats were not considered to host Influenza A viruses until 2012-2013, when two phylogenetically distinct lineages, designated Influenza A virus subtype H17N10 and H18N11, were identified in Central and South American bats.[citation needed]
Discovery
editThe species of bats currently known to carry bat influenza are common in Central and South America.[1] The first bat flu virus, IAV H17N10, was first discovered in 2009 in little yellow-shouldered bats (Sturnira lilium) in Guatemala.[1] In 2012 a novel influenza virus (H18N11) was discovered in bats in South America. This strain was found to be divergent from the better-understood Influenza A viruses most commonly found in fowls and humans.[2] The complete sequence of IAV H17N10 was extracted from Sturnira lilium in 2012. In 2013, the sequence of IAV H18N11 was extracted from flat-faced fruit-eating bats (Artibeus planirostris) from Peru.[3][4][5] In contrast to human and avian influenza A viruses that use sialic acid receptors, the bat flu strains H17N10 and H18N11 infect cells by using major histocompatibility complex class II molecules on the host cell surface.[6]
Other species
editInfluenza A viruses circulate among a wide variety of species, being able to cross species barriers and establish new virus lineages in birds and mammals.[5] However, bat influenza viruses of the H18N11 subtype have been found to be poorly adapted to non-bat species.[7]
Infection in humans
editAs of 2019, no cases of influenza in humans have been definitively linked to bats.[8] Research suggests that human cells do not support growth of bat flu viruses in the test tube, implying that these viruses would need to undergo significant changes to adapt and easily infect humans. However, a transmission potential has been found, but the mechanism of transmission from bats to humans differs from that from other species.[8] It has been argued that bat flu viruses could become capable of infecting humans by exchanging genetic information with human flu viruses through reassortment.[1]
References
edit- ^ a b c d "Bat Influenza (Flu)". cdc.gov. Retrieved 30 June 2020.
- ^ "Turns Out, Bat Influenza Can Give You the Flu". globalbiodefense.com. 17 June 2019. Retrieved 27 June 2020.
- ^ "Characterization of bat influenza viruses". uniklinik-freiburg.de. Retrieved 30 June 2020.
- ^ "New flu virus found in bats". Nature. 503 (7475): 169. 2013. doi:10.1038/503169e. Retrieved 30 June 2020.
- ^ a b Ciminski K, Pfaff F, Beer M, Schwemmle M (2020). "Bats reveal the true power of influenza A virus adaptability". PLOS Pathogens. 16 (4): e1008384. doi:10.1371/journal.ppat.1008384. PMC 7161946. PMID 32298389.
- ^ Karakus U, Thamamongood T, Ciminski K, Ran W, Günther S, Pohl M, Eletto DA, Beer M, Schwemmle M, Stertz S (2019). "MHC class II proteins mediate cross-species entry of bat influenza viruses". Nature. 567 (7746): 109–112. Bibcode:2019Natur.567..109K. doi:10.1038/s41586-019-0955-3. PMID 30787439. S2CID 67769877.
- ^ Ciminski K, Ran W, Gorka M, Lee J, Schinköthe J, Eckley M, Murrieta MA, Aboellail TA, Campbell CL, Ebel GD, Ma J, Pohlmann A, Franzke K, Ulrich R, Hoffmann D, Garcia-Sastre A, Ma W, Schountz T, Beer M, Schwemmle M (2019). "Bat influenza viruses transmit among bats but are poorly adapted to non-bat species". Nature Microbiology. 4 (12): 2298–2309. doi:10.1038/s41564-019-0556-9. PMC 7758811. PMID 31527796. S2CID 202580293.
- ^ a b "Study Identifies Transmission Mechanism of Bat Influenza". contagionlive.com. 21 March 2019. Retrieved 27 June 2020.