ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene .[ 5] [ 6]
ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP -dependent signal transduction to the nucleus.[ 7] [ 8]
MRP4/ABCC4 expression is dysregulated in several cancers [ 9] [ 10] [ 11] [ 12]
Interactive pathway map
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Click on genes, proteins and metabolites below to link to respective articles. [ § 1]
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Fluorouracil (5-FU) Activity
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