Papers by Prokopios Magiatis
The results of the olive analysis concerning the levels of oleocanthal, oleacein, oleuropein agly... more The results of the olive analysis concerning the levels of oleocanthal, oleacein, oleuropein aglycon and ligstroside aglycon in 340 monovarietal samples from Greece and California are presented
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Journal of Essential Oil Bearing Plants, 2007
ABSTRACT The essential oils of the flowers of Narcissus tazetta subsp. tazetta and Narcissus sero... more ABSTRACT The essential oils of the flowers of Narcissus tazetta subsp. tazetta and Narcissus serotinus were analyzed by GC and GC/MS. Nineteen compounds were identified and the major components were trans-ocimene (61.12%) for Narcissus tazetta and benzyl acetate (19.36%) for Narcissus serotinus.
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Zeitschrift fĆ¼r Naturforschung. C, Journal of biosciences
The chemical composition of the essential oils of Achillea holosericea, Achillea taygetea, Achill... more The chemical composition of the essential oils of Achillea holosericea, Achillea taygetea, Achillea fraasii was determined by GC/MS analysis. Among the ninety-five assayed constituents, camphor, borneol and 1,8-cineol were found to be the major components. The in-vitro antimicrobial activity of these essential oils was evaluated against six bacteria indicating that the first is totally inactive, while the other two possess moderate to strong activities mainly against the Gram negative strains. The essential oil of A. fraasii was also active against the tested pathogenic fungi.
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Zeitschrift fĆ¼r Naturforschung C, 2000
Prokopios Magiatis, Eleni Melliou, Eugenia Tsitsa, Catherine Charvala, and Sofia Mitaku* Laborato... more Prokopios Magiatis, Eleni Melliou, Eugenia Tsitsa, Catherine Charvala, and Sofia Mitaku* Laboratory of Pharmacognosy, University of Athens, Panepistimiopolis, Zografou, GR-15771 Athens, Greece. Fax (301) 7274594. E-mail: mitakou@pharm.uoa.gr * Author for correspondence ...
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The effects of various plant growth regulators and culture conditions on the production of volati... more The effects of various plant growth regulators and culture conditions on the production of volatile secondary metabolites from callus cultures of Chamomile (Chamomilla recutita) inflorescence were investigated and the most efficient conditions were determined. The essential oil composition was assayed by GC-MS analysis and found to contain chamomillol, gossonorol, cubenol, alpha-cadinol, (-)-alpha-bisabolol, 1-azulenethanol acetate and (-)-alpha-bisabolol acetate.
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Planta Medica, 2007
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Journal of Medicinal Chemistry, 2002
A series of diversely substituted biarylolefins based on carbohydrate and dihydroxyethylene scaff... more A series of diversely substituted biarylolefins based on carbohydrate and dihydroxyethylene scaffolds were synthesized and evaluated for antiproliferative activity against a panel of human tumor cell lines. Among the thirty-five yet unknown biarylolefins prepared, six displayed potent antiproliferative activities with IC(50) values in the micromolar and submicromolar range. As a new type of antiproliferative agent, the most potent compound 26 showed an IC(50) value of 70 nM against SK-OV3 cell line (ovarian cancer). All the synthesized compounds exhibited a poor or modest tubulin polymerization inhibitory activity suggesting another mode of action for these compounds. Molecular docking simulations to the colchicine binding site of tubulin of representative compounds have been used to explain the lack of activity as inhibitors of tubulin polymerization.
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Molecules, 2007
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Planta Medica, 2014
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Papers by Prokopios Magiatis