Abstract
The distribution of caprine leucocyte antigens (CLA) in goats from four different breeds (n=546) affected by caprine arthritis-encephalitis virus (CAEV)-induced arthritis were determined and compared breed for breed with those of infected but clinically healthy controls (n=402). Differences in frequencies of some of the CLA specificities between the affected and control groups were found, but after correction of the ordinary P values for number of observed alleles, only the CLA Be7 specificity in the Saanen breed showed a significant deviation at the 0.05 probability level. Animals of the Saanen breed carrying this specificity are less prone to develop arthritis after CAE virus infection than goats lacking this specificity. Eleven groups (multiple-case families or halfsibling groups with at least two informative diseased offspring/group) were analyzed for manifestation of the disease and segregation of the parental haplotypes. The results of the maximum likelihood test of association (P<0.005) and the calculated high lod score value of 5.70 give evidence for linkage between the locus encoding the determined class I CLA alleles and a hypothetical locus (i) coding for genes responsible for arthritis resistance/susceptibility. The particular class I CLA allele associated with the disease susceptibility varied from family to family, however. These data provide the first evidence that CAE virus-induced arthritis in the goat is genetically influenced by the MHC system; they also suggest that susceptibility/resistance genes are not directly associated with the determined class I gene products but rather are in close genetic linkage.
Similar content being viewed by others
References
Adams, D. S., Crawford, T. B., and Klevjer-Anderson, P.: A pathogenetic study of the early connective tissue lesions of viral caprine arthritis encephalitis. Am J Pathol 99.: 257–278, 1980
Adams, D. S., Klevjer-Anderson, P., Carlson, J. L., McGuire, T. C., and Gorham, J. R.: Transmission and control of caprine arthritisencephalitis virus. Am J Vet Res 44: 1670–1675, 1983
Adams, D. S., Oliver, R. E., Ameghino, E., DeMartini, J. C., Verwoerd D. W., Houwers, D. J., Waghela, S., Gorham, J. R., Hyllseth, B., Dawson, M., Trigo, F. J., and McGuire, T. C.: Global survey of serological evidence of caprine arthritis-encephalitis virus infection. Vet Rec 115: 493–495, 1984
Böyum, A.: Separation of leucocytes from blood and bone marrow. Scand J Clin Lab Invest 21: Suppl. 197: 31–50, 1968
Clements, J. E., Narayan, O., and Cork, L. C.: Biochemical characterization of the virus causing leukoencephalitis and arthritis in goats. J Gen Virol 50: 423–427, 1979
Collins, W. M., Briles, W. E., Zsigray, R. M., Dunlop, W. R., Corbett, A. C., Clark, K. K., Marks, J. L., and McGrail, T. P.: The B locus (MHC) in the chicken: association with the fate of RSV-induced tumors. Immunogenetics 5: 333–343, 1977
Cork, L. C., Hadlow, W. J., Crawford, T. B., Gorham, J. R., and Piper, R. C.: Infectious leukoencephalomyelitis of young goats. J Infect Dis 129: 134–141, 1974
Crawford, T. B., Adams, D. S., Cheevers, W. P., and Cork, L. C.: Chronic arthritis in goats caused by a retrovirus. Science 207: 997–999, 1980
Crawford, T. B. and Adams, D. S.: Caprine arthritis-encephalitis: clinical features and presence of antibody in selected goat populations. JAVMA 178: 713–719, 1981
Gonda, M. A., Brown, M. J., Carter, S. G., Kost, T. A., Bess, J. W., Arthur L. O., and Van Der Maaten, M. J.: Characterization and molecular cloning of a bovine lentivirus related to human immunodeficiency virus. Nature 330: 388–391, 1987
Klevjer-Anderson, P. and McGuire, T. C.: Antibody response of rabbits and goats to caprine arthritis-encephalitis virus. Infect Immun 38: 455–461, 1982
Krieg, T. and Ruff, G.: CAE=Caprine-Arthritis-Encephalitis. Der Kleinviehzüchter 3: 93–98, 1988
Lewin H. A. and Bernoco, D.: Evidence for BoLA-linked resistance and susceptibility to subclinical progression of bovine leukaemia virus infection. Anim Genet 17: 197–207, 1986
Lonai, P. and Haran-Ghera N.: Resistance genes to murine leukemia in the I immune response region of the H-2 complex. J Exp Med 146: 1164–1168, 1977
Longenecker, B. M., Pazderka, F., Gavora, J. S., Spencer, J. L., and Ruth, R. F.: Lymphoma induced by herpesvirus: resistance associated with a major histocompatibility gene. Immunogenetics 3: 401–407, 1976
McGuire, T. C.: The immune response to viral antigens as a determinant of arthritis in caprine arthritis-encephalitis virus infection. Yet Immunol Immunopathol 17: 465–470, 1987
McGuire, T. C., Adams, D. S., Johnson, G. C., Klevejer-Anderson, P., Barbee, D. D., and Gorham, J. R.: Acute arthritis in caprine arthritis-encephalitis virus challenge exposure of vaccinated or persistently infected goats. Am J Vet Res 47: 537–540, 1986
Millot, P., Chatelain, J., and Cathala, F.: Le complexe majeur d'histocompatibilité OLA du mouton. Fréquence des facteurs chez des ovins atteints ou non de Tremblante (Scrapie). Comptes-rendus des Seances de l'Académie des Sciences 294: 87–89, 1982
Morton, N. E.: Sequential tests for the detection of linkage. Am J Hum Genet 7: 277–318, 1955
Morton, N. E.: Outline of Genetic Epidemiology, p. 95, S. Karger, Basel, New York, 1982
Narayan, O., Wolinsky, J. S., Clements, J. E., Strandberg, J. D., Griffin, D. E., and Cork, L. C.: Slow virus replication: the role of macrophages in the persistence and expression of visna virus in sheep and goats. J Gen Virol 59: 345–356, 1982
Narayan, O., Kennedy-Stoskopf, S., Sheffer, D., Griffin, D. E., and Clements, J. E.: Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes/macrophages. Infect Immun 41: 67–73, 1983
Nesse, L. L. and Larsen, H. J.: Lymphocyte antigens in Norwegian goats: serological and genetic studies. Anim Genet 18: 261–268, 1987
Nesse, L. L. and Ruff, G.: A comparison of lymphocyte antigen specificities in Norwegian and Swiss goats. Anim Genet, in press, 1988
Ruff, G.: Investigations on the Caprine Leucocyte Antigen (CLA) System. Thesis no. 8468, ETH Zurich, 1987
Scorzasmeraldi, R., Lazzarin, F. G., Eisera, N. D., Moroni, M., and Zanussi, C.: HLA-associated susceptibility to aquired immunodeficiency syndrome (AIDS) in Italien patients with human immunodeficiency virus infection. Lancet 2: 1187–1189, 1986
Svejgaard, A., Platz, P., and Ryder, L. P.: HLA and disease 1982. A Survey. Immunol Rev 70: 193–218, 1983
Van Dam, R., van Werkhofen, C. B., van der Donk, J. A., and Goudswaard, J.: Histocompatibility in ruminants. The production and evaluation of alloantibodies for CLA-typing in goats. J Immunogenet 3: 237–244, 1976
Zwahlen, R., Aeschbacher, M., Balcer, T., Stucki, M., WyderWalther, M., Weiss, M., and Steck, F.: Lentivirusinfektionen bei Ziegen mit Carpitis und interstitieller Mastitis. Schweiz Arch Tierheilkd 125: 281–299, 1983
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ruff, G., Lazary, S. Evidence for linkage between the caprine leucocyte antigen (CLA) system and susceptibility to CAE virus-induced arthritis in goats. Immunogenetics 28, 303–309 (1988). https://doi.org/10.1007/BF00364227
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00364227