Neural Basis of Motivational and Cognitive Control, 2011
Despite the fact that early hypometabolism and neural degeneration in posterior cingulate cortex ... more Despite the fact that early hypometabolism and neural degeneration in posterior cingulate cortex (CGp) predict cognitive decline in Alzheimer's disease, and CGp hyperactivity predicts cognitive dysfunction in schizophrenia as well as first-degree relatives, the function of this brain area remains unclear. The disparate evidence for CGp involvement in a variety of cognitive and behavioral processes has belied any simple functional description. Here we develop a new model that proposes that CGp integrates the recent history of rewards, ...
The neural mechanisms supporting the ability to recognize and respond to fictive outcomes, outcom... more The neural mechanisms supporting the ability to recognize and respond to fictive outcomes, outcomes of actions that one has not taken, remain obscure. We hypothesized that neurons in the anterior cingulate cortex (ACC), which monitors the consequences of actions and mediates subsequent changes in behavior, would respond to fictive reward information. We recorded responses of single neurons during performance of a choice task that provided information about the reward values of options that were not chosen. We ...
Neural Basis of Motivational and Cognitive Control, 2011
Despite the fact that early hypometabolism and neural degeneration in posterior cingulate cortex ... more Despite the fact that early hypometabolism and neural degeneration in posterior cingulate cortex (CGp) predict cognitive decline in Alzheimer's disease, and CGp hyperactivity predicts cognitive dysfunction in schizophrenia as well as first-degree relatives, the function of this brain area remains unclear. The disparate evidence for CGp involvement in a variety of cognitive and behavioral processes has belied any simple functional description. Here we develop a new model that proposes that CGp integrates the recent history of rewards, ...
The neural mechanisms supporting the ability to recognize and respond to fictive outcomes, outcom... more The neural mechanisms supporting the ability to recognize and respond to fictive outcomes, outcomes of actions that one has not taken, remain obscure. We hypothesized that neurons in the anterior cingulate cortex (ACC), which monitors the consequences of actions and mediates subsequent changes in behavior, would respond to fictive reward information. We recorded responses of single neurons during performance of a choice task that provided information about the reward values of options that were not chosen. We ...
Uploads
Papers by J. Pearson