Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose
"> Figure 1
<p>Crystal structure of [Cu<sub>2</sub>(BDC)<sub>2</sub>(DABCO)] along the <span class="html-italic">b</span>-axis (hydrogen atoms are not given for the sake of clarity).</p> "> Figure 2
<p>SEM images of only MOF (<b>A</b>); CuNPs/NGO (carbonized at 600 °C (<b>B</b>); 700 °C (<b>C</b>); 800 °C (<b>D</b>); 900 °C (<b>E</b>); and TEM image (<b>F</b>) of CuNPs/NGO (900 °C)).</p> "> Figure 3
<p>XRD pattern of CuNPs/NGO (carbonized at 600 °C (<b>a</b>), 700 °C (<b>b</b>), 800 °C (<b>c</b>) and 900 °C (<b>d</b>)).</p> "> Figure 4
<p>(<b>A</b>) N<sub>2</sub> adsorption analysis of CuNPs/NGO (600 (a), 700 (b), 800 (c) and 900 °C (d)); (<b>B</b>) pore size distribution curves of CuNPs/NGO (600 (a), 700 (b), 800 (c) and 900 °C (d)).</p> "> Figure 5
<p>CVs obtained at CuNPs/NGO (600 (<b>A</b>), 700 (<b>B</b>), 800 (<b>C</b>) and 900 °C (<b>D</b>)) modified SPCEs in 0.1 NaOH with and without 3 mM glucose at the scan rate of 50 mV/s.</p> "> Figure 6
<p>CVs observed without (<b>a</b>) and with each addition (<b>b</b>–<b>k</b>) of 1 mM glucose at CuNPs/NGO/SPCE in 0.1 M NaOH at the scan rate of 50 mV/s.</p> "> Figure 7
<p>(<b>A</b>) amperometric response at CuNPs/NGO/SPCE upon successive additions of glucose (1, 10, 50, 100 and 200 μM (a–e)) of glucose in 0.1 M NaOH (scan rate = 50 mV s<sup>−1</sup>, applied potential = 0.4 V); (<b>B</b>) calibration plot of <span class="html-italic">I</span><sub>p</sub> vs. (<span class="html-italic">glucose</span>).</p> ">
Abstract
:1. Introduction
2. Experimental Section
2.1. Materials and Methods
2.2. Apparatus
2.3. Preparation of [Cu2(BDC)2(DABCO)]
2.4. Preparation of CuNPs/NGO
2.5. Electrode Fabrication
3. Results and Discussion
3.1. Formation of [Cu2(BDC)2(DABCO)]
3.2. Characterization of Prepared CuNPs/NGO Nanocomposite
3.3. Electrochemical Behavior of CuNPs/NGO Nanocomposites
3.4. Amperometric i–t Determination
3.5. Selectivity Studies
3.6. Repeatability, Reproducibility and Stability
3.7. Real Sample Analysis
4. Conclusions
Supplementary Materials
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Sample | Cu wt % | N wt % | C wt % | H wt % | O wt % |
---|---|---|---|---|---|
CuNPs/NGO(600) | 71.63 | 2.10 | 22.84 | 1.72 | 1.71 |
CuNPs/NGO(700) | 71.68 | 1.96 | 22.73 | 1.79 | 1.84 |
CuNPs/NGO(800) | 71.34 | 1.94 | 23.82 | 1.83 | 1.07 |
CuNPs/NGO(900) | 77.43 | 1.44 | 17.21 | 1.19 | 2.73 |
Sample | Surface Area/m2 g−1 | Total Pore Volume (cc/g) P/Po ~ 0.99 | Pore Size (nm) | |
---|---|---|---|---|
BET | Langmuir | |||
CuNPs/NGO(600) | 185 | 193 | 0.31 | 2, 5 |
CuNPs/NGO(700) | 144 | 151 | 0.34 | 2, 3–5 |
CuNPs/NGO(800) | 108 | 113 | 0.32 | 1–2, 5 |
CuNPs/NGO(900) | 86 | 90 | 0.25 | 1.2 |
Modified Electrode | a LR (μM) | b LOD (μM) | Sensitivity | Ref. |
---|---|---|---|---|
3D N-Co-CNT@NG) | 25–10,830 | 0.1 | 9.05 µA mM−1 cm−2 | [40] |
Cu@porous carbon | 1–6000 | 0.6 | 10,100 | [41] |
[Cu3(c btc)2] nanocube | 1–2250 | 1 | 549 µA mM−1 cm−2 | [42] |
Cu-d BDD | 1–50 | 10 | 2.3 µA mM−1 cm−2 | [43] |
N-doped Carbon-Cu nanohybrids | 5–2100 | 0.7 | 223.6 µA mM−1 cm−2 | [44] |
Graphene oxide and NiO nanofibers | 2–600 | 0.77 | 1100 | [45] |
Cu nanoporous | 10–500 | 40 | 220 µA mM−1 cm−2 | [46] |
Cu NPs/SWCNTs | 0.5–500 | 0.3 | 0.256 µA mM−1 cm−2 | [47] |
Cu/CuO/ZnO | 100–1000 | 18 | 408 µA mM−1 cm−2 | [48] |
AuCu/CNTs | 80–9260 | 4 | 22 µA mM−1 cm−2 | [49] |
CuNPs/NGO | 1–1803 | 0.44 | 2500 µA mM−1 cm−2 | This work |
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Sivasankar, K.; Rani, K.K.; Wang, S.-F.; Devasenathipathy, R.; Lin, C.-H. Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose. Nanomaterials 2018, 8, 429. https://doi.org/10.3390/nano8060429
Sivasankar K, Rani KK, Wang S-F, Devasenathipathy R, Lin C-H. Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose. Nanomaterials. 2018; 8(6):429. https://doi.org/10.3390/nano8060429
Chicago/Turabian StyleSivasankar, Kulandaivel, Karuppasamy Kohila Rani, Sea-Fue Wang, Rajkumar Devasenathipathy, and Chia-Her Lin. 2018. "Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose" Nanomaterials 8, no. 6: 429. https://doi.org/10.3390/nano8060429