Daily Fungal Cell-Free DNA Testing to Assess Clinical Status during Candida krusei Fungemia
<p>Timeline of the patient’s myelodysplastic syndrome, leukemia history, and index fungemia. The timeline arrow in light blue represents the history before admission during which the index fungemia occurred. The timeline arrow in darker blue represents the admission during which the index fungemia occurred. <span class="html-italic">C. krusei: Candida krusei</span>; GMR: giant magnetoresistance; Haplo-HCT: haploidentical allogeneic hematopoietic cell transplant; MDS: myelodysplastic syndrome; VRE: vancomycin-resistant <span class="html-italic">Enterococcus faecium</span>.</p> "> Figure 2
<p>Photographs of skin lesions from this index case patient: panel (<b>A</b>): skin lesions located on the right arm and in the right antecubital area; panel (<b>B</b>): skin lesion located on the right side of the neck.</p> ">
Abstract
:1. Introduction
2. Materials and Methods
3. Case Patient
4. Results
5. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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White Blood Count | Blood Culture | Skin Biopsy Culture | Maximum Fever | GMR Signal | |
---|---|---|---|---|---|
Day+0 | 0.4 × 109 cells/L | Positive for C. krusei at four time points | 102 °F/38.9 °C | 617 | |
Day+1 | 0.3 × 109 cells/L | Negative | 101.1 °F/38.4 °C | 409 | |
Day+2 | 0.5 × 109 cells/L | Positive for C. krusei | 102.5 °F/39.2 °C | 1606 | |
Day+3 | 0.3 × 109 cells/L | Negative | Positive for C. krusei | 102 °F/38.9 °C | 1878 |
Day+4 | 0.4 × 109 cells/L | Negative | 102.6 °F/39.2 °C | 1855 | |
Day+5 | 0.4 × 109 cells/L | Negative | 102.4 °F/39.1 °C | 2112 | |
Day+6 | 0.7 × 109 cells/L | Negative | 99.1 °F/37.3 °C | 2264 | |
Day+7 | 1.0 × 109 cells/L | 99.3 °F/37.4 °C | 2264 | ||
Day+8 | 1.3 × 109 cells/L | 99 °F/37.2 °C | 1958 |
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Young, J.-A.H.; Liu, X.; Porter, E.; Sweet, H.; Wang, W.; Evans, A.F.; Zhang, C.; Obeid, K.M. Daily Fungal Cell-Free DNA Testing to Assess Clinical Status during Candida krusei Fungemia. J. Fungi 2024, 10, 449. https://doi.org/10.3390/jof10070449
Young J-AH, Liu X, Porter E, Sweet H, Wang W, Evans AF, Zhang C, Obeid KM. Daily Fungal Cell-Free DNA Testing to Assess Clinical Status during Candida krusei Fungemia. Journal of Fungi. 2024; 10(7):449. https://doi.org/10.3390/jof10070449
Chicago/Turabian StyleYoung, Jo-Anne H., Xiaoying Liu, Emma Porter, Hannah Sweet, Wei Wang, Anton F. Evans, Chi Zhang, and Karam M. Obeid. 2024. "Daily Fungal Cell-Free DNA Testing to Assess Clinical Status during Candida krusei Fungemia" Journal of Fungi 10, no. 7: 449. https://doi.org/10.3390/jof10070449