Health-Related Quality of Life and Associated Comorbidities in Community-Dwelling Women with Breast Cancer
<p>Prevalence of having problems in each EQ-5D dimension among participants with and without breast cancer (n = 12,218).</p> "> Figure 2
<p>Multivariable-adjusted EQ-5D index score according to the presence of arthritis and depression among participants with breast cancer (n = 244). Values are presented as mean ± standard errors, adjusted for age, body mass index, physical activity, alcohol consumption, smoking status, household income, residence, current breast cancer status, current breast cancer treatment, years since cancer diagnosis, hypertension, diabetes, cardiovascular disease, and the presence of depression (for arthritis analysis) or arthritis (for depression analysis).</p> ">
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Health-Related Quality of Life
2.3. Comorbidity and Breast Cancer-Related Factors
2.4. Variables
2.5. Statistical Analysis
3. Results
3.1. Characteristics of Participants
3.2. Health-Related Quality of Life in Participants with and without Breast Cancer
3.3. Factors Associated with Health-Related Quality of Life in Participants with Breast Cancer
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | Participants without Breast Cancer (n = 11,974) | Participants with Breast Cancer (n = 244) | p Value |
---|---|---|---|
Weighted number (n) | 8,963,619 | 189,043 | |
Age (years) | 63.30 ± 0.12 | 62.13 ± 0.69 | 0.091 |
Body mass index (kg/m2) | 24.12 ± 0.04 | 24.05 ± 0.28 | 0.804 |
Arthritis | 0.125 | ||
No | 69.4 (0.5) | 74.4 (3.0) | |
Yes | 30.6 (0.5) | 25.6 (3.0) | |
Depression | 0.492 | ||
No | 92.2 (0.3) | 93.5 (1.7) | |
Yes | 7.8 (0.3) | 6.5 (1.7) | |
Hypertension | 0.012 | ||
No | 53.9 (0.6) | 62.9 (3.4) | |
Yes | 46.1 (0.6) | 37.1 (3.4) | |
Diabetes | 0.544 | ||
No | 88.9 (0.4) | 90.2 (2.1) | |
Yes | 11.1 (0.4) | 9.8 (2.1) | |
Cardiovascular disease | 0.086 | ||
No | 93.5 (0.3) | 96.1 (1.2) | |
Yes | 6.5 (0.3) | 3.9 (1.2) | |
Physical activity | 0.048 | ||
Sufficient | 63.3 (0.6) | 55.8 (3.9) | |
Insufficient | 36.7 (0.6) | 44.2 (3.9) | |
Current alcohol consumption | 0.001 | ||
No | 70.6 (0.5) | 81.9 (2.8) | |
Yes | 29.4 (0.5) | 18.1 (2.8) | |
Current smoking | 0.077 | ||
No | 96.6 (0.2) | 98.7 (0.7) | |
Yes | 3.4 (0.2) | 1.3 (0.7) | |
Household income | 0.365 | ||
Low | 28.5 (0.6) | 26.3 (3.4) | |
Lower-middle | 24.9 (0.5) | 25.5 (3.3) | |
Upper-middle | 22.7 (0.5) | 27.9 (3.6) | |
High | 23.9 (0.6) | 20.3 (3.0) | |
Residence | 0.254 | ||
Urban | 80.5 (1.1) | 84.2 (3.1) | |
Rural | 19.5 (1.1) | 15.8 (3.1) |
Variables | Mobility | Self-Care | Usual Activity | Pain/Discomfort | Anxiety/Depression |
---|---|---|---|---|---|
Arthritis | |||||
No | 14.9 (3.2) | 7.0 (2.5) | 8.1 (2.5) | 19.0 (3.4) | 13.1 (3.3) |
Yes | 44.1 (5.5) | 9.9 (3.6) | 19.8 (4.8) | 59.9 (5.9) | 26.6 (5.8) |
p value | <0.001 | 0.483 | 0.020 | <0.001 | 0.042 |
Depression | |||||
No | 21.1 (3.0) | 5.8 (1.9) | 9.7 (2.3) | 27.1 (3.4) | 15.3 (2.9) |
Yes | 41.3 (12.7) | 34.7 (13.6) | 31.3 (11.3) | 62.2 (13.0) | 34.1 (11.5) |
p value | 0.076 | <0.001 | 0.011 | 0.008 | 0.056 |
Hypertension | |||||
No | 18.6 (3.5) | 7.9 (2.6) | 9.6 (2.5) | 26.8 (4.2) | 16.5 (4.1) |
Yes | 28.8 (5.0) | 7.3 (3.1) | 13.6 (4.1) | 33.9 (5.0) | 16.5 (4.3) |
p value | 0.087 | 0.884 | 0.376 | 0.264 | 0.998 |
Diabetes | |||||
No | 21.4 (3.1) | 7.6 (2.3) | 11.6 (2.4) | 29.3 (3.5) | 16.9 (3.0) |
Yes | 31.4 (10.9) | 8.5 (4.1) | 6.4 (4.8) | 30.6 (9.0) | 12.9 (5.0) |
p value | 0.334 | 0.847 | 0.424 | 0.893 | 0.508 |
Cardiovascular disease | |||||
No | 21.0 (3.0) | 7.6 (2.1) | 11.3 (2.3) | 29.0 (3.4) | 16.9 (2.9) |
Yes | 57.9 (14.3) | 11.8 (8.3) | 7.1 (6.9) | 38.9 (15.1) | 7.1 (6.9) |
p value | 0.005 | 0.556 | 0.636 | 0.506 | 0.341 |
Currently presence of breast cancer | |||||
No | 21.3 (3.6) | 4.9 (2.0) | 8.8 (2.5) | 28.8 (4.2) | 16.3 (3.8) |
Yes | 24.0 (4.9) | 11.8 (3.9) | 14.4 (4.0) | 30.3 (5.2) | 16.9 (3.8) |
p value | 0.652 | 0.091 | 0.216 | 0.817 | 0.909 |
Currently on breast cancer treatment | |||||
No | 21.3 (3.2) | 5.1 (1.8) | 8.9 (2.3) | 27.1 (3.8) | 17.8 (3.6) |
Yes | 25.1 (6.0) | 14.3 (5.1) | 16.8 (5.2) | 35.4 (6.2) | 13.3 (3.4) |
p value | 0.565 | 0.033 | 0.109 | 0.242 | 0.348 |
Years since cancer diagnosis | |||||
<5 years | 21.3 (5.3) | 10.1 (4.1) | 12.4 (4.2) | 29.9 (5.6) | 20.6 (4.8) |
≥5 years | 23.0 (3.5) | 6.6 (2.2) | 10.5 (2.6) | 29.2 (4.1) | 14.6 (3.4) |
p value | 0.788 | 0.407 | 0.693 | 0.914 | 0.287 |
Mobility | Self-Care | Usual Activity | Pain/Discomfort | Anxiety/Depression | |
---|---|---|---|---|---|
Arthritis | 3.24 (1.39–7.53) | 1.22 (0.34–4.33) | 2.36 (0.92–6.08) | 7.30 (3.62–14.73) | 2.43 (0.85–6.98) |
Depression | 2.40 (0.85–6.82) | 7.02 (1.97–25.01) | 5.73 (1.52–21.59) | 5.58 (1.49–20.87) | 3.81 (1.14–12.72) |
Hypertension | 0.53 (0.23–1.25) | 0.72 (0.24–2.16) | 1.00 (0.38–2.66) | 1.02 (0.49–2.15) | 0.75 (0.27–2.05) |
Diabetes | 1.50 (0.51–4.43) | 0.85 (0.31–2.33) | 0.30 (0.06–1.47) | 1.00 (0.35–2.87) | 0.74 (0.30–1.83) |
Cardiovascular disease | 2.23 (0.66–7.48) | 2.73 (0.40–18.72) | 0.30 (0.02–3.62) | 0.98 (0.25–3.78) | 0.26 (0.04–1.78) |
Current presence of breast cancer | 0.84 (0.27–2.62) | 2.49 (0.43–14.54) | 0.82 (0.23–2.88) | 0.65 (0.19–2.28) | 0.99 (0.34–2.84) |
Currently on breast cancer treatment | 1.10 (0.33–3.61) | 1.80 (0.46–7.09) | 1.58 (0.45–5.50) | 1.61 (0.47–5.53) | 0.35 (0.12–1.02) |
Years since cancer diagnosis | 1.40 (0.56–3.51) | 0.83 (0.32–2.17) | 1.31 (0.51–3.38) | 1.08 (0.36–3.26) | 2.23 (0.90–5.56) |
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Jang, D.K.; Nam, H.S.; Kim, J.; Kim, Y.H. Health-Related Quality of Life and Associated Comorbidities in Community-Dwelling Women with Breast Cancer. J. Clin. Med. 2024, 13, 5321. https://doi.org/10.3390/jcm13175321
Jang DK, Nam HS, Kim J, Kim YH. Health-Related Quality of Life and Associated Comorbidities in Community-Dwelling Women with Breast Cancer. Journal of Clinical Medicine. 2024; 13(17):5321. https://doi.org/10.3390/jcm13175321
Chicago/Turabian StyleJang, Dong Kee, Hyung Seok Nam, Jieun Kim, and Yeo Hyung Kim. 2024. "Health-Related Quality of Life and Associated Comorbidities in Community-Dwelling Women with Breast Cancer" Journal of Clinical Medicine 13, no. 17: 5321. https://doi.org/10.3390/jcm13175321