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Enodthelin 1 Is Elevated in Plasma and Explants From Patients Having Uterine Leiomyomas

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Reproductive Sciences Aims and scope Submit manuscript

Abstract

Objective

To determine a role for endothelin (ET) in progression of uterine fibroids.

Design

An in vitro model of fibroid and myometrium cultivation.

Patients

A total of 32 women undergoing hysterectomies for uterine fibroids and 11 women undergoing hysterectomies for abnormal uterine bleeding (control population).

Results

Women with uterine fibroids were hypertensive and displayed significantly greater circulating ET-1 compared to control patients. Secretion of ET-1 was greater from the fibroids compared to myometrium explants. Endothelin 1 secretion was attenuated with blockade of the angiotensin II type 1 or endothelinA receptors. Hypoxia stimulated ET-1 secretion from both myometrium and fibroid explants. Preproendothelin messenger RNA expression increased with hypoxia from fibroid explants compared to normoxic controls.

Conclusions

These data support the hypothesis that uterine fibroids are associated with hypertension and increased ET-1, which is exacerbated with hypoxia. These data suggest a possible link between mechanisms of blood pressure regulation and development of uterine leiomyoma.

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Author information

Authors and Affiliations

  1. Departments of Pharmacology & Obstetrics & Gynecology, University of Mississippi Medical Center, 2500 N. State St., 39212, Jackson, MS, USA

    Kedra Wallace PhD, Krystal Chatman MS, Justin Porter, Venessia Johnson RN & Babbette LaMarca PhD

  2. Pharmacology, University of Mississippi Medical Center, Jackson, MS, USA

    Jeremy Scott, Janae Moseley BS & Babbette LaMarca PhD

Authors
  1. Kedra Wallace PhD
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  2. Krystal Chatman MS
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  3. Justin Porter
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  4. Jeremy Scott
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  5. Venessia Johnson RN
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  6. Janae Moseley BS
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  7. Babbette LaMarca PhD
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Corresponding author

Correspondence to Babbette LaMarca PhD.

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Wallace, K., Chatman, K., Porter, J. et al. Enodthelin 1 Is Elevated in Plasma and Explants From Patients Having Uterine Leiomyomas. Reprod. Sci. 21, 1196–1205 (2014). https://doi.org/10.1177/1933719114542018

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  • DOI: https://doi.org/10.1177/1933719114542018

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