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Angiotensin II: a hormone that affects lipid metabolism in adipose tissue

International Journal of Obesity volume 31, pages 382–384 (2007)Cite this article

Abstract

Background:

Alterations in adipose tissue lipolysis may contribute to the pathophysiology of obesity and insulin resistance. We examined the effects of angiotensin II (Ang II) on abdominal subcutaneous adipose tissue lipolysis in humans.

Methods and results:

First, adipocytes obtained from nine normal weight and seven obese subjects were stimulated with Ang II (10−14–10−6 M). Glycerol concentration in the medium, used as an indicator of adipocyte lipolysis, was significantly reduced (∼20%) after Ang II stimulation in adipocytes from normal weight (P=0.04) and obese subjects (P<0.001). Based on these observations, adipocytes of seven additional obese subjects were stimulated with lower doses of Ang II (10−17–10−6 M) in the presence and absence of Ang II type 1 (AT1) receptor blockade. Lipolysis was dose dependently inhibited by ∼20 to 25% after Ang II stimulation (P=0.001). AT1 receptor blockade completely abolished the Ang II-induced effects (P=0.35).

Conclusion:

Ang II directly inhibits abdominal subcutaneous adipocyte lipolysis in normal weight and obese subjects via the AT1 receptor.

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Acknowledgements

We thank Kerstin Wåhlén, Eva Sjölin and Freek Bouwman for excellent technical assistance. Losartan was provided by Merck Sharp and Dohme (Haarlem, The Netherlands).

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Authors and Affiliations

  1. Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht, The Netherlands

    G H Goossens, E E Blaak, W H M Saris & M A van Baak

  2. Department of Medicine, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden

    P Arner

Authors
  1. G H Goossens
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  2. E E Blaak
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  3. P Arner
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  4. W H M Saris
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  5. M A van Baak
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Correspondence to G H Goossens.

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Goossens, G., Blaak, E., Arner, P. et al. Angiotensin II: a hormone that affects lipid metabolism in adipose tissue. Int J Obes 31, 382–384 (2007). https://doi.org/10.1038/sj.ijo.0803388

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  • DOI: https://doi.org/10.1038/sj.ijo.0803388

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