Abstract
The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases. While a growing number of well-conducted, prospective, randomized, controlled, clinical trials are emerging and investigations of underlying mechanisms of action are being undertaken, questions remain with respect to the specific immune and physiological effects of probiotics in health and disease. This Review considers recent advances in clinical trials of probiotics for intestinal disorders in both adult and pediatric populations. An overview of recent in vitro and in vivo research related to potential mechanisms of action of various probiotic formulations is also considered.
Key Points
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Probiotics are increasingly being used for various digestive diseases, including IBS, IBD, necrotizing enterocolitis, acute infectious diarrhea and antibiotic-associated diarrhea
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Not all probiotic strains are appropriate for all ailments
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Depending on the strain, probiotics have different underlying mechanisms of action to provide a beneficial effect
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In addition to live organisms, probiotic-derived products, such as surface-layer proteins and bacteriocins may provide beneficial effects
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Probiotics are contraindicated in certain patient populations, including those with severe immune deficiencies
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Acknowledgements
Work in the authors' laboratories is supported by grants from the National Institutes of Health (WAW: R01 HD012437, R01 DK070260, P01 DK033506 and P30 DK040561), the Canadian Institutes of Health Research (PMS), and a Fay Shapiro-Cutler grant-in-aid from the Crohn's and Colitis Foundation of Canada (MGG & PMS). MGG is the recipient of a CIHR/CCFC/Canadian Association of Gastroenterology fellowship. PMS is the recipient of a Canada Research Chair in Gastrointestinal Disease.
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M. G. Gareau researched data for the article and wrote the article. All three authors contributed equally to discussions of the content of the article and to review/editing of the manuscript before submission.
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M. G. Gareau declares no competing interests. P. M. Sherman has received grant/research support from the Institut Rosell Lallemand and is a Consultant for Mead Johnson, Abbott, and Nestle. W. A. Walker is a Consultant for Dannon and Mead Johnson.
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Gareau, M., Sherman, P. & Walker, W. Probiotics and the gut microbiota in intestinal health and disease. Nat Rev Gastroenterol Hepatol 7, 503–514 (2010). https://doi.org/10.1038/nrgastro.2010.117
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DOI: https://doi.org/10.1038/nrgastro.2010.117
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