Abstract
It is now well established that regulatory T (TR) cells can inhibit harmful immunopathological responses directed against self or foreign antigens. However, many key aspects of TR cell biology remain unresolved, especially with regard to their antigen specificities and the cellular and molecular pathways involved in their development and mechanisms of action. We will review here recent findings in these areas, outline a model for how TR cells may inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of TR cell function.
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Acknowledgements
We thank O. Annacker, S. Read, D. Mason, L. Stephens and A. Gallimore for numerous helpful discussions and critical review of the manuscript. K. M. and F. P. are supported by the Wellcome Trust.
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Maloy, K., Powrie, F. Regulatory T cells in the control of immune pathology. Nat Immunol 2, 816–822 (2001). https://doi.org/10.1038/ni0901-816
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DOI: https://doi.org/10.1038/ni0901-816
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