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Acknowledgements
We appreciate the support of an anonymous donor to the research of J.M.S., without whom this research would not have been possible. We thank the participants and many ophthalmologists throughout the country who contributed to this study, and D. Mirel and the US National Center for Research Resources (NCRR) Broad Institute Center for Genotyping and Analysis for help with design and execution of the genotyping. This research was supported in part by grants K08AR055688-01A1 (S. Raychaudhuri), RO1-EY11309 (J.M.S.), K12-EY16335 (L.S.), U01 MH085520-01 (S. Ripke) and R01-HG004517 (M.L.) from the US National Institutes of Health (NIH); NIH National Eye Institute intramural program; Massachusetts Lions Eye Research Fund, Inc.; a Challenge Grant from Research to Prevent Blindness to the New England Eye Center, Department of Ophthalmology, Tufts University School of Medicine; a Career Development Award from Research to Prevent Blindness (L.S.); a Harvard Catalyst Faculty Fellowship (L.S.); and the Macular Degeneration Research Fund of the Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine. We thank the Myocardial Infarction Genetics Consortium (MIGen) study for the use of their genotype data as control data in our study. The MIGen study was funded by grants from the NIH–National Heart, Lung and Blood Institute (R01HL087676) and the NIH-NCRR.
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S. Raychaudhuri, J.M.S. and M.J.D. conceived this study, conducted statistical analyses, wrote the initial manuscript and interpreted all results. J.M.S., L.S. and R.R. organized the clinical cohort. S. Raychaudhuri, B.M.N. and J.F. conducted initial processing of the SNP data. S. Ripke, M.L., G.A. and AS imputed missing genotype data.
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The authors declare no competing financial interests.
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Supplementary Methods, Supplementary Figure 1, Supplementary Tables 1–2 (PDF 451 kb)
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Raychaudhuri, S., Ripke, S., Li, M. et al. Associations of CFHR1–CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent. Nat Genet 42, 553–555 (2010). https://doi.org/10.1038/ng0710-553
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DOI: https://doi.org/10.1038/ng0710-553
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