Loss of integrin-mediated attachment to the extracellular matrix triggers apoptosis through the activation of caspases. A recent study shows that disruption of integrin function also induces mitochondrial release of Bit1, a caspase-independent effector of apoptosis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Meredith, J.E., Fazeli, B. & Schwartz, M.A. Mol. Biol. Cell 4, 953–961 (1993).
Frisch, S.M. & Screaton, R.A. Curr. Opin. Cell Biol. 13, 555–562 (2001).
Jan, Y. et al. Cell 116, 751–762 (2004).
De Pereda, J.M. et al. J. Biol. Chem. 279, 8111–8115 (2004).
Yochum, G.S. & Ayer, D.E. Mol. Cell. Biol. 22, 7868–7876 (2002).
Yao, J. et al. Mech. Dev. 93, 105–115 (2000).
Yu, X., Li, P., Roeder, R.G. & Wang, Z. Mol. Cell. Biol. 21, 4614–4625 (2001).
Brantjes, H., Roose, J., van De Wetering, M. & Clevers, H. Nucleic Acids Res. 29, 1410–1419 (2001).
Tetsuka, T. et al. J. Biol. Chem. 275, 4383–4390 (2000).
Qwarnstrom, E.E., Ostberg, C.O., Turk, G.L., Richardson, C.A. & Bomsztyk, K. J. Biol. Chem. 269, 30765–30768 (1994).
Meredith, J., Jr, Mu, Z., Saido, T. & Du, X. J. Biol. Chem. 273, 19525–19531 (1998).
Cande, C., Vahnsen, N., Garrido, C. & Kroemer, G. Cell Death Differ. 10.1038/sj.cdd.4401400 (2004).
Matter, M. & Ruoslahti, E. J. Biol. Chem. 276, 27757–27763 (2001).
Stupack, D.G., Puente, X.S., Boutsaboualoy, S., Storgard, C.M. & Cheresh, D.A. J. Cell Biol. 155, 459–470 (2001).
Pritzker, L.B., Scatena, M. & Giachelli, C.M. Mol. Biol. Cell 10.1091/mbc.E04-01-0059 (2004).
Shipp, M.A. et al. Nature Med. 8, 68–74 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stupack, D., Cheresh, D. A Bit-role for integrins in apoptosis. Nat Cell Biol 6, 388–389 (2004). https://doi.org/10.1038/ncb0504-388
Issue Date:
DOI: https://doi.org/10.1038/ncb0504-388