Abstract
Maternal effect genes produce mRNA or proteins that accumulate in the egg during oogenesis. We show here that Mater, a mouse oocyte protein dependent on the maternal genome, is essential for embryonic development beyond the two-cell stage. Females lacking the maternal effect gene Mater are sterile. Null males are fertile.
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Acknowledgements
We thank H. Westphal for discussions, and M. DePamphilis for discussions and critical reading of the manuscript.
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Tong, ZB., Gold, L., Pfeifer, K. et al. Mater, a maternal effect gene required for early embryonic development in mice. Nat Genet 26, 267–268 (2000). https://doi.org/10.1038/81547
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DOI: https://doi.org/10.1038/81547
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