Abstract
In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the formation of a complete gene. In addition, mutations are somatically introduced at a high rate into the amino-terminal region. Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism.
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Tonegawa, S. Somatic generation of antibody diversity. Nature 302, 575–581 (1983). https://doi.org/10.1038/302575a0
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DOI: https://doi.org/10.1038/302575a0