Abstract
THE schistosomicidal activity of the mirasan series (I) and of cyclic analogues (II) and (III) in different host species has been reviewed1,2. Members of all three series displayed high activity in mice, but none of these compounds appeared to be active in primates except members of series (III), which displayed some activity in monkeys although they lacked convincing activity in man.
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References
Gönnert, R., Bull. Wld Hlth Org., 25, 702 (1961).
Standen, O. D., in Experimental Chemotherapy (edit. by Schnitzer, R. J., and Hawking, F.), 1, 773 (Academic Press, London, 1963).
Foster, R., Cheetham, B. L., and Mesmer, E. T., J. Trop. Med., Hyg., 71, 139 (1968).
Mauss, H., Kölling, H., and Gönnert, R., Med. u. Chemie, 5, 185 (1956).
Rosi, D., Lewis, T. R., Lorenz, R., Freele, H., Berberian, D. A., and Archer, S., J. Med. Chem., 10, 877 (1967).
Rosi, D., Peruzzotti, G., Dennis, E. W., Berberian, D. A., Freele, H., Tullar, B. F., and Archer, S., J. Med. Chem., 10, 867 (1967).
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RICHARDS, H., FOSTER, R. A New Series of 2-Aminomethyltetrahydroquinoline Derivatives displaying Schistosomicidal Activity in Rodents and Primates. Nature 222, 581–582 (1969). https://doi.org/10.1038/222581a0
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DOI: https://doi.org/10.1038/222581a0