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Mathematical Modeling of Cell Polarity Establishment of Budding Yeast

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Abstract

The budding yeast Saccharomyces cerevisiae is a powerful model system for studying the cell polarity establishment. The cell polarization process is regulated by signaling molecules, which are initially distributed in the cytoplasm and then recruited to a proper location on the cell membrane in response to spatial cues or spontaneously. Polarization of these signaling molecules involves complex regulation, so the mathematical models become a useful tool to investigate the mechanism behind the process. In this review, we discuss how mathematical modeling has shed light on different regulations in the cell polarization. We also propose future applications for the mathematical modeling of cell polarization and morphogenesis.

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Acknowledgements

WC benefited greatly from many stimulating discussions on cell polarization modeling with his mentor Dr. Ching-Shan Chou. The authors dedicate this paper to the memory of Dr. Chou, who had a great contribution to cell polarization modeling.

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Authors and Affiliations

  1. Department of Mathematics, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China

    Yue Liu, Jun Xie & Wing-Cheong Lo

  2. Department of Molecular Genetics, The Ohio State University, Columbus, OH, USA

    Hay-Oak Park

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  1. Yue Liu
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Correspondence to Wing-Cheong Lo.

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Liu, Y., Xie, J., Park, HO. et al. Mathematical Modeling of Cell Polarity Establishment of Budding Yeast. Commun. Appl. Math. Comput. 6, 218–235 (2024). https://doi.org/10.1007/s42967-022-00240-y

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