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Diagnosi istologica delle varianti aggressive del carcinoma papillare tiroideo

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L'Endocrinologo Aims and scope

Sommario

Il carcinoma papillare tiroideo (PTC) è la neoplasia più frequente della tiroide e ha un comportamento clinico indolente. Tuttavia, sono state identificate delle varianti del PTC che mostrano un comportamento biologicamente più aggressivo. Tali varianti comprendono la variante sclerosante diffusa (DSV), la variante a cellule alte (TCV), la variante a cellule colonnari (CCV), la variante solida (SV) e la variante hobnail (HV). Esse presentano un comportamento più aggressivo rispetto al classico PTC e una maggiore tendenza alla recidiva locale e alla metastatizzazione linfonodale e a distanza. Per migliorare la prognosi dei pazienti è di fondamentale importanza riuscire a diagnosticare precisamente tali varianti per pianificare un trattamento più aggressivo. Lo scopo di questa revisione è quello di presentare le principali caratteristiche cliniche, istologiche e molecolari delle varianti aggressive del carcinoma papillare tiroideo per fornire i parametri istologici utili a definire la strategia terapeutica più adatta per i pazienti affetti da queste forme.

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Authors and Affiliations

  1. Dipartimento di Patologia Umana, dell’Adulto e dell’Età Evolutiva “Gaetano Barresi”, Università di Messina, Messina, Italia

    Francesca Mazzeo, Antonio Ieni, Giovanni Tuccari & Guido Fadda

  2. Dipartimento di scienze biomediche, odontoiatriche e delle immagini morfologiche e funzionali, Università di Messina, Messina, Italia

    Cristina Pizzimenti

  3. Dipartimento ProMISE (promozione della salute, materno-infantile, di medicina interna e specialistica di eccellenza) – Sezione di Anatomia Patologica, Università degli Studi di Palermo, Palermo, Italia

    Desideria Coco & Gaetano Militi

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  1. Desideria Coco
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  4. Francesca Mazzeo
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  5. Antonio Ieni
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Corresponding author

Correspondence to Guido Fadda.

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Conflitto di interesse

Gli autori Desideria Coco, Cristina Pizzimenti, Gaetano Militi, Francesca Mazzeo, Antonio Ieni, Giovanni Tuccari e Guido Fadda dichiarano di non avere conflitti di interesse.

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Proposto da Rosaria M. Ruggeri.

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Coco, D., Pizzimenti, C., Militi, G. et al. Diagnosi istologica delle varianti aggressive del carcinoma papillare tiroideo. L'Endocrinologo 23, 7–13 (2022). https://doi.org/10.1007/s40619-021-01006-z

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  • DOI: https://doi.org/10.1007/s40619-021-01006-z

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