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The effects of exercise on epigenetic modifications: focus on DNA methylation, histone modifications and non-coding RNAs

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Abstract

Physical activity on a regular basis has been shown to bolster the overall wellness of an individual; research is now revealing that these changes are accompanied by epigenetic modifications. Regular exercise has been proven to make intervention plans more successful and prolong adherence to them. When it comes to epigenetic changes, there are four primary components. This includes changes to the DNA, histones, expression of particular non-coding RNAs and DNA methylation. External triggers, such as physical activity, can lead to modifications in the epigenetic components, resulting in changes in the transcription process. This report pays attention to the current knowledge that pertains to the epigenetic alterations that occur after exercise, the genes affected and the resulting characteristics.

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Authors and Affiliations

  1. Xiamen Academy of Art and Design, Fuzhou University, Xiamen, 361024, Fujian, China

    Junxiong Zhang

  2. College of Physical Education, Taiyuan University of Technology, Taiyuan, 030024, Shanxi, China

    Zhongxin Tian & Chao Qin

  3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Reza Momeni

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  1. Junxiong Zhang
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  2. Zhongxin Tian
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  3. Chao Qin
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  4. Mohammad Reza Momeni
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Junxiong Zhang, Zhongxin Tian, and Chao Qin contributed to manuscript drafting and data collection. All the authors approved the final paper. Mohammad Reza Momeni oversaw the study.

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Correspondence to Junxiong Zhang, Zhongxin Tian or Mohammad Reza Momeni.

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Zhang, J., Tian, Z., Qin, C. et al. The effects of exercise on epigenetic modifications: focus on DNA methylation, histone modifications and non-coding RNAs. Human Cell 37, 887–903 (2024). https://doi.org/10.1007/s13577-024-01057-y

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