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Genetic variations in monocyte chemoattractant protein-1 and susceptibility to ovarian cancer

  • Research Article
  • Published:
Tumor Biology

Abstract

Monocyte chemoattractant protein-1 (MCP-1) is a chemokine which plays critical roles in regulating host immune responses. Researches have shown that MCP-1 may greatly participate in the development of different cancers. In the current study, we investigated the effect of MCP-1 on ovarian cancer by examining the association between MCP-1 genetic polymorphisms and the susceptibility to ovarian cancer. MCP-1 −2158A/G and MCP-1 −362C/G polymorphisms were examined in ovarian cancer patients and healthy controls by using polymerase chain reaction–restriction fragment length polymorphism analysis. Results showed that percentages of MCP-1 −2158GG genotype and G allele were significantly higher in ovarian cancer patients than in controls (odd ratio (OR) = 1.87; 95 % confidence interval (CI), 1.19–2.76; P = 0.012 and OR = 1.47; 95 % CI, 1.11–1.79; P = 0.003; data were adjusted for age and smoking status). The MCP-1 −362GG genotype also revealed increased number in patients. Stratification analyses presented that ovarian cancer cases with serous-papillary type had significantly increased percentage of −362GG genotype than those with other types (13.1 versus 5.0 %, P = 0.032; data were adjusted for age and smoking status). Also, we evaluated the relation between these two polymorphisms and serum level of MCP-1. We identified that the subjects with MCP-1 −2158AG and GG genotypes had clearly increased serum level of MCP-1 than those with AA genotype. These data suggest that MCP-1 may be involved in the pathogenesis of ovarian cancer.

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Authors and Affiliations

  1. Department of Gynaecology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830011, China

    Li Li

  2. Department of Radiation Oncology, The Third Affiliated Hospital of Guangzhou Medical University, No. 63, Duobao Road, Guangzhou, Guangdong, 510150, China

    Jinshan Zhang & Ge Wen

  3. Department of Gynaecology, The Maternal and Child Health Hospital, Shandong, 250000, China

    Xin Weng

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  1. Li Li
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  2. Jinshan Zhang
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  3. Xin Weng
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  4. Ge Wen
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Correspondence to Jinshan Zhang.

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Li, L., Zhang, J., Weng, X. et al. Genetic variations in monocyte chemoattractant protein-1 and susceptibility to ovarian cancer. Tumor Biol. 36, 233–238 (2015). https://doi.org/10.1007/s13277-014-2619-0

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  • DOI: https://doi.org/10.1007/s13277-014-2619-0

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