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Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

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Abstract

Protein oxidation has been demonstrated in preeclampsia, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). The present study comparatively evaluated ischemia modified albumin (IMA) and advanced oxidation protein products (AOPP) in different HDP and investigated their association with total antioxidant activity (AOA) and total thiols. There was a significant increase in AOPP and IMA, a significant decrease in AOA, total thiols and albumin in every HDP compared to controls. Among HDP groups, eclampsia patients showed more significant change in each of the parameter. IMA and AOPP were negatively associated with AOA in every HDP and with total thiols only in eclampsia. The present study supports the hypothesis of oxidative stress, as evidenced by increased protein oxidation, decreased antioxidant status and significant negative association between protein oxidation and AOA in every HDP. The imbalance of prooxidants and antioxidants was further augmented in eclampsia.

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Abbreviations

AOPP:

Advanced oxidation protein products

IMA:

Ischemia modified albumin

AOA:

Total antioxidant activity

ROS:

Reactive oxygen species

HDP:

Hypertensive disorders in pregnancy

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Acknowledgments

The authors acknowledge the cooperation given by Ms. Mamatha, Chief librarian, Yenepoya University and Ms. Shobha, Laboratory technician, Chirashree Maternity Hospital, Surathkal, Mangalore.

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Authors and Affiliations

  1. Department of Biochemistry, Yenepoya Medical College, Yenepoya University, Deralakatte, Mangalore, Karnataka, 575018, India

    Jyothi M. P. D’souza, Sindhu Harish & Vinitha Ramanath Pai

  2. Chirashree Maternity Hospital, Surathkal, Mangalore, Karnataka, India

    Chitra Shriyan

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  1. Jyothi M. P. D’souza
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  2. Sindhu Harish
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  3. Vinitha Ramanath Pai
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Correspondence to Sindhu Harish.

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D’souza, J.M.P., Harish, S., Pai, V.R. et al. Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy. Ind J Clin Biochem 32, 200–206 (2017). https://doi.org/10.1007/s12291-016-0584-7

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  • DOI: https://doi.org/10.1007/s12291-016-0584-7

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