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The Role of Diet in Inflammatory Bowel Disease

  • Inflammatory Bowel Disease (S Hanauer, Section Editor)
  • Published:
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Abstract

Purpose of Review

Diet may play both a causal and therapeutic role for inflammatory bowel disease (IBD). Physicians caring for patients with IBD are often asked to make dietary recommendations. However, there are no well-established guidelines on the use of diet as a treatment of IBD. In this review, we describe the evidence supporting diet as a potential cause for IBD, patient-perceived symptoms based on diet, current research on various diets as a treatment for IBD, and areas of future research.

Recent Findings

New studies in murine models suggest that dietary emulsifiers may trigger the gut inflammatory cascade. New studies of restriction diets in patients have shown a relationship between dietary intake, symptoms, and bowel inflammation.

Summary

Until several ongoing clinical trials are completed, a reasonable approach to dietary recommendations for patients with IBD is to propose a well-balanced, healthy (low-fat, low-sugar) diet prepared from fresh ingredients, such as the Mediterranean diet, with exclusions of self-identified foods that worsen or trigger IBD-related symptoms.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Molodecky NA, Soon IS, Rabi DM, Ghali WA, Ferris M, Chernoff G, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46–54 e42. quiz e30

    Article  PubMed  Google Scholar 

  2. Loftus Jr EV. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology. 2004;126(6):1504–17.

    Article  PubMed  Google Scholar 

  3. Molodecky NA, Kaplan GG. Environmental risk factors for inflammatory bowel disease. Gastroenterol Hepatol (N Y). 2010;6(5):339–46.

    PubMed Central  Google Scholar 

  4. Wu GD, Bushmanc FD, Lewis JD. Diet, the human gut microbiota, and IBD. Anaerobe. 2013;24:117–20.

    Article  CAS  PubMed  Google Scholar 

  5. Lewis JD. The role of diet in inflammatory bowel disease. Gastroenterol Hepatol (N Y). 2016;12(1):51–3.

    PubMed Central  Google Scholar 

  6. Lee D, Albenberg L, Compher C, Baldassano R, Piccoli D, Lewis JD, et al. Diet in the pathogenesis and treatment of inflammatory bowel diseases. Gastroenterology. 2015;148(6):1087–106.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lewis JD, Abreu MT. Diet as a trigger or therapy for inflammatory bowel diseases. Gastroenterology. 2016.

  8. Lewis JD, Chen EZ, Baldassano RN, Otley AR, Griffiths AM, Lee D, et al. Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn’s disease. Cell Host Microbe. 2015;18(4):489–500.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. • Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015;519(7541):92–6. This study shows that emulsifiers, commonly found in processed food, are implicated in chronic inflammatory diseases, including inflammatory bowel disease.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Mazzon E, Muia C, Paola RD, Genovese T, Menegazzi M, De Sarro A, et al. Green tea polyphenol extract attenuates colon injury induced by experimental colitis. Free Radic Res. 2005;39(9):1017–25.

    Article  CAS  PubMed  Google Scholar 

  11. Youn J, Lee JS, Na HK, Kundu JK, Surh YJ. Resveratrol and piceatannol inhibit iNOS expression and NF-kappaB activation in dextran sulfate sodium-induced mouse colitis. Nutr Cancer. 2009;61(6):847–54.

    Article  CAS  PubMed  Google Scholar 

  12. Cohen AB, Lee D, Long MD, Kappelman MD, Martin CF, Sandler RS, et al. Dietary patterns and self-reported associations of diet with symptoms of inflammatory bowel disease. Dig Dis Sci. 2013;58(5):1322–8.

    Article  CAS  PubMed  Google Scholar 

  13. Zallot C, Quilliot D, Chevaux JB, Peyrin-Biroulet C, Gueant-Rodriguez RM, Freling E, et al. Dietary beliefs and behavior among inflammatory bowel disease patients. Inflamm Bowel Dis. 2013;19(1):66–72.

    Article  PubMed  Google Scholar 

  14. • Hou JK, Abraham B, El-Serag H. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Am J Gastroenterol. 2011;106(4):563–73. This systematic review provides a comprehensive overview of the literature on various food groups and their association with risk of Crohn’s disease or ulcerative colitis.

    Article  CAS  PubMed  Google Scholar 

  15. Amre DK, D'Souza S, Morgan K, Seidman G, Lambrette P, Grimard G, et al. Imbalances in dietary consumption of fatty acids, vegetables, and fruits are associated with risk for Crohn’s disease in children. Am J Gastroenterol. 2007;102(9):2016–25.

    Article  CAS  PubMed  Google Scholar 

  16. Sakamoto N, Kono S, Wakai K, Fukuda Y, Satomi M, Shimoyama T, et al. Dietary risk factors for inflammatory bowel disease: a multicenter case-control study in Japan. Inflamm Bowel Dis. 2005;11(2):154–63.

    Article  PubMed  Google Scholar 

  17. Jantchou P, Morois S, Clavel-Chapelon F, Boutron-Ruault MC, Carbonnel F. Animal protein intake and risk of inflammatory bowel disease: the E3N prospective study. Am J Gastroenterol. 2010;105(10):2195–201.

    Article  CAS  PubMed  Google Scholar 

  18. Hart AR, Luben R, Olsen A, Tjonneland A, Linseisen J, Nagel G, et al. Diet in the aetiology of ulcerative colitis: a European prospective cohort study. Digestion. 2008;77(1):57–64.

    Article  PubMed  Google Scholar 

  19. John S, Luben R, Shrestha SS, Welch A, Khaw KT, Hart AR. Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study. Eur J Gastroenterol Hepatol. 2010;22(5):602–6.

    Article  CAS  PubMed  Google Scholar 

  20. Reif S, Klein I, Lubin F, Farbstein M, Hallak A, Gilat T. Pre-illness dietary factors in inflammatory bowel disease. Gut. 1997;40(6):754–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Investigators IBDiES, Tjonneland A, Overvad K, Bergmann MM, Nagel G, Linseisen J, et al. Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort study. Gut. 2009;58(12):1606–11.

    Article  Google Scholar 

  22. Geerling BJ, Dagnelie PC, Badart-Smook A, Russel MG, Stockbrugger RW, Brummer RJ. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol. 2000;95(4):1008–13.

    Article  CAS  PubMed  Google Scholar 

  23. Tragnone A, Valpiani D, Miglio F, Elmi G, Bazzocchi G, Pipitone E, et al. Dietary habits as risk factors for inflammatory bowel disease. Eur J Gastroenterol Hepatol. 1995;7(1):47–51.

    CAS  PubMed  Google Scholar 

  24. Miller B, Fervers F, Rohbeck R, Strohmeyer G. Sugar consumption in patients with Crohn’s disease. Verh Dtsch Ges Inn Med. 1976;82(Pt 1):922–4.

    PubMed  Google Scholar 

  25. Kasper H, Sommer H. Dietary fiber and nutrient intake in Crohn’s disease. Am J Clin Nutr. 1979;32(9):1898–901.

    CAS  PubMed  Google Scholar 

  26. Jarnerot G, Jarnmark I, Nilsson K. Consumption of refined sugar by patients with Crohn’s disease, ulcerative colitis, or irritable bowel syndrome. Scand J Gastroenterol. 1983;18(8):999–1002.

    Article  CAS  PubMed  Google Scholar 

  27. Grover Z, Muir R, Lewindon P. Exclusive enteral nutrition induces early clinical, mucosal and transmural remission in paediatric Crohn’s disease. J Gastroenterol. 2014;49(4):638–45.

    Article  CAS  PubMed  Google Scholar 

  28. Zachos M, Tondeur M, Griffiths AM. Enteral nutritional therapy for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2007;1:CD000542.

    Google Scholar 

  29. Borrelli O, Cordischi L, Cirulli M, Paganelli M, Labalestra V, Uccini S, et al. Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn’s disease: a randomized controlled open-label trial. Clin Gastroenterol Hepatol. 2006;4(6):744–53.

    Article  PubMed  Google Scholar 

  30. Lee D, Baldassano RN, Otley AR, Albenberg L, Griffiths AM, Compher C, et al. Comparative effectiveness of nutritional and biological therapy in North American children with active Crohn’s disease. Inflamm Bowel Dis. 2015;21(8):1786–93.

    Article  PubMed  Google Scholar 

  31. Suskind DL, Wahbeh G, Cohen SA, Damman CJ, Klein J, Braly K, et al. Patients perceive clinical benefit with the specific carbohydrate diet for inflammatory bowel disease. Dig Dis Sci. 2016;61(11):3255–60.

    Article  CAS  PubMed  Google Scholar 

  32. Cohen SA, Gold BD, Oliva S, Lewis J, Stallworth A, Koch B, et al. Clinical and mucosal improvement with specific carbohydrate diet in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2014;59(4):516–21.

    Article  CAS  PubMed  Google Scholar 

  33. Olendzki BC, Silverstein TD, Persuitte GM, Ma Y, Baldwin KR, Cave D. An anti-inflammatory diet as treatment for inflammatory bowel disease: a case series report. Nutr J. 2014;13:5.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Sigall-Boneh R, Pfeffer-Gik T, Segal I, Zangen T, Boaz M, Levine A. Partial enteral nutrition with a Crohn’s disease exclusion diet is effective for induction of remission in children and young adults with Crohn’s disease. Inflamm Bowel Dis. 2014;20(8):1353–60.

    Article  PubMed  Google Scholar 

  35. Croagh C, Shepherd SJ, Berryman M, Muir JG, Gibson PR. Pilot study on the effect of reducing dietary FODMAP intake on bowel function in patients without a colon. Inflamm Bowel Dis. 2007;13(12):1522–8.

    Article  PubMed  Google Scholar 

  36. Prince AC, Myers CE, Joyce T, Irving P, Lomer M, Whelan K. Fermentable carbohydrate restriction (low FODMAP diet) in clinical practice improves functional gastrointestinal symptoms in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2016;22(5):1129–36.

    Article  PubMed  Google Scholar 

  37. Knight-Sepulveda K, Kais S, Santaolalla R, Abreu MT. Diet and inflammatory bowel disease. Gastroenterol Hepatol (N Y). 2015;11(8):511–20.

    Google Scholar 

  38. Gearry RB, Irving PM, Barrett JS, Nathan DM, Shepherd SJ, Gibson PR. Reduction of dietary poorly absorbed short-chain carbohydrates (FODMAPs) improves abdominal symptoms in patients with inflammatory bowel disease—a pilot study. J Crohns Colitis. 2009;3(1):8–14.

    Article  PubMed  Google Scholar 

  39. U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans 2010. https://www.cnpp.usda.gov/sites/default/files/dietary_guidelines_for_americans/PolicyDoc.pdf. Accessed 15 Jan 2017.

  40. Knoops KT, de Groot LC, Kromhout D, Perrin AE, Moreiras-Varela O, Menotti A, et al. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA. 2004;292(12):1433–9.

    Article  PubMed  Google Scholar 

  41. Bo S, Ponzo V, Goitre I, Fadda M, Pezzana A, Beccuti G, et al. Predictive role of the Mediterranean diet on mortality in individuals at low cardiovascular risk: a 12-year follow-up population-based cohort study. J Transl Med. 2016;14:91.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Marlow G, Ellett S, Ferguson IR, Zhu S, Karunasinghe N, Jesuthasan AC, et al. Transcriptomics to study the effect of a Mediterranean-inspired diet on inflammation in Crohn’s disease patients. Hum Genomics. 2013;7:24.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Hirai F, Ishihara H, Yada S, Esaki M, Ohwan T, Nozaki R, et al. Effectiveness of concomitant enteral nutrition therapy and infliximab for maintenance treatment of Crohn’s disease in adults. Dig Dis Sci. 2013;58(5):1329–34.

    Article  CAS  PubMed  Google Scholar 

  44. Sazuka S, Katsuno T, Nakagawa T, Saito M, Saito K, Matsumura T, et al. Concomitant use of enteral nutrition therapy is associated with sustained response to infliximab in patients with Crohn’s disease. Eur J Clin Nutr. 2012;66(11):1219–23.

    Article  CAS  PubMed  Google Scholar 

  45. Tanaka T, Takahama K, Kimura T, Mizuno T, Nagasaka M, Iwata K, et al. Effect of concurrent elemental diet on infliximab treatment for Crohn’s disease. J Gastroenterol Hepatol. 2006;21(7):1143–9.

    Article  CAS  PubMed  Google Scholar 

  46. Yamamoto T, Nakahigashi M, Umegae S, Matsumoto K. Prospective clinical trial: enteral nutrition during maintenance infliximab in Crohn’s disease. J Gastroenterol. 2010;45(1):24–9.

    Article  CAS  PubMed  Google Scholar 

  47. Nguyen DL, Palmer LB, Nguyen ET, McClave SA, Martindale RG, Bechtold ML. Specialized enteral nutrition therapy in Crohn’s disease patients on maintenance infliximab therapy: a meta-analysis. Therap Adv Gastroenterol. 2015;8(4):168–75.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Lewis JD, Albenberg L, Lee D, Kratz M, Gottlieb K, Reinisch W. The importance and challenges of dietary intervention trials for inflammatory bowel disease. Inflamm Bowel Dis. 2017.

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Correspondence to James D. Lewis.

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Conflict of Interest

Raina Shivashankar declares no conflict of interest.

James Lewis has received honorarium for consulting and research grant support from Nestle Health Science.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Disclosures

Dr. Lewis has received research funding from Nestle Health Science.

Additional information

This article is part of the Topical Collection on Inflammatory Bowel Disease

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Shivashankar, R., Lewis, J.D. The Role of Diet in Inflammatory Bowel Disease. Curr Gastroenterol Rep 19, 22 (2017). https://doi.org/10.1007/s11894-017-0563-z

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