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Hydroxyapatite/alginate/polyvinyl alcohol/agar composite double-network hydrogels as injectable drug delivery microspheres

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Abstract

An injectable and biodegradable drug delivery system to release antibiotics at a controllable rate to treat anti-bone infection was prepared. The system was based on nanocomposites of hydroxyapatite nanoparticles (HAP) and double-network hydrogels of sodium alginate (SA)/polyvinyl alcohol (PVA) prepared in the form of microspheres embedded in injectable agar gel. The double-network hydrogels of SA/PVA were prepared by sequential crosslinking of sodium alginate with calcium ions and then PVA by freeze-thawing method. The agar gel was used as a thermos-reversible gel to facilitate injection of microspheres. The characteristics of microspheres were analyzed by FTIR, XRD, SEM and water swelling. The drug release rate of the microspheres was measured at various compositions of the delivery system components. The results showed that increase in PVA content of hydrogels led to a tighter double-network which consequently reduced the drug release rate. Loading of the drug into HAP nanoparticles as drug nano-containers, prolonged the drug release time from 1 to 6 days when the content of HAP nanoparticles was within the range of 2.5 to 5%. The antibacterial activities of the drug-loaded composite hydrogels were evaluated against E. coli bacteria by disk diffusion tests showing anti-bacterial effectiveness of such drug delivery systems.

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References

  • Boral S, Bohidar H (2012) Effect of water structure on gelation of agar in glycerol solutions and phase diagram of agar organogels. J Phys Chem B 116:7113–7121

    Article  CAS  PubMed  Google Scholar 

  • Cho AR, Chun YG, Kim BK, Park DJ (2014) Preparation of alginate–CaCl2 microspheres as resveratrol carriers. J Mater Sci 49:4612–4619

    Article  CAS  Google Scholar 

  • Dash S, Murthy PN, Nath L, Chowdhury P (2010) Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm 67:217–223

    CAS  PubMed  Google Scholar 

  • Degirmenbasi N, Kalyon DM, Birinci E (2006) Biocomposites of nanohydroxyapatite with collagen and poly (vinyl alcohol). Colloids Surf, B 48:42–49

    Article  CAS  Google Scholar 

  • Deng Y, Wang H, Zhang L, Li Y, Wei S (2013) In situ synthesis and in vitro biocompatibility of needle-like nano-hydroxyapatite in agar–gelatin co-hydrogel. Mater Lett 104:8–12

    Article  CAS  Google Scholar 

  • Fenglan X, Yubao L, Xuejiang W, Jie W, Aiping Y (2004) Preparation and characterization of nano-hydroxyapatite/poly (vinyl alcohol) hydrogel biocomposite. J Mater Sci 39:5669–5672

    Article  Google Scholar 

  • Fundueanu G, Nastruzzi C, Carpov A, Desbrieres J, Rinaudo M (1999) Physico-chemical characterization of Ca-alginate microparticles produced with different methods. Biomaterials 20(15):1427–1435

    Article  CAS  PubMed  Google Scholar 

  • Holloway JL, Lowman AM, Palmese GR (2013) The role of crystallization and phase separation in the formation of physically cross-linked PVA hydrogels. Soft Matter 9:826–833

    Article  CAS  Google Scholar 

  • Hua S, Ma H, Li X, Yang H, Wang A (2010) pH-sensitive sodium alginate/poly (vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium. Int J Biol Macromol 46:517–523

    Article  CAS  PubMed  Google Scholar 

  • Kim G-M, Asran AS, Michler GH, Simon P, Kim J-S (2008) Electrospun PVA/HAp nanocomposite nanofibers: biomimetics of mineralized hard tissues at a lower level of complexity. Bioinspir Biomim 3:046003

    Article  PubMed  Google Scholar 

  • Li H, Jiang F, Ye S, Wu Y, Zhu K, Wang D (2016) Bioactive apatite incorporated alginate microspheres with sustained drug-delivery for bone regeneration application. Mater Sci Eng, C 62:779–786

    Article  Google Scholar 

  • Mansur HS, Sadahira CM, Souza AN, Mansur AA (2008) FTIR spectroscopy characterization of poly (vinyl alcohol) hydrogel with different hydrolysis degree and chemically crosslinked with glutaraldehyde. Mater Sci Eng, C 28:539–548

    Article  CAS  Google Scholar 

  • Martínez-Gómez F, Guerrero J, Matsuhiro B, Pavez J (2017) In vitro release of metformin hydrochloride from sodium alginate/polyvinyl alcohol hydrogels. Carbohyd Polym 155:182–191

    Article  Google Scholar 

  • Nayak AK, Hasnain MS, Nanda SS, Yi DK (2019) Hydroxyapatite-alginate based matrices for drug delivery. Curr Pharm Des 25:3406–3416

    Article  CAS  PubMed  Google Scholar 

  • Prasanna APS, Venkatasubbu GD (2018) Sustained release of amoxicillin from hydroxyapatite nanocomposite for bone infections. Prog Biomater 7:289–296

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Venkatasubbu GD, Ramasamy S, Avadhani G, Ramakrishnan V, Kumar J (2013) Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles. Powder Technol 235:437–442

    Article  CAS  Google Scholar 

  • Xu Q, Czernuszka JT (2008) Controlled release of amoxicillin from hydroxyapatite-coated poly (lactic-co-glycolic acid) microspheres. J Control Release 127:146–153

    Article  CAS  PubMed  Google Scholar 

  • Xu Y, Zhan C, Fan L, Wang L, Zheng H (2007) Preparation of dual crosslinked alginate–chitosan blend gel beads and in vitro controlled release in oral site-specific drug delivery system. Int J Pharm 336:329–337

    Article  CAS  PubMed  Google Scholar 

  • Yan J, Miao Y, Tan H, Zhou T, Ling Z, Chen Y, Xing X, Hu X (2016) Injectable alginate/hydroxyapatite gel scaffold combined with gelatin microspheres for drug delivery and bone tissue engineering. Mater Sci Eng, C 63:274–284

    Article  CAS  Google Scholar 

  • Zhang S, Han D, Ding Z, Wang X, Zhao D, Hu Y, Xiao X (2019) Fabrication and characterization of one interpenetrating network hydrogel based on sodium alginate and polyvinyl alcohol. J Wuhan Univ Technol-Mater Sci Ed 34:744–751

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran

    Parisa Ghazagh & Masoud Frounchi

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  1. Parisa Ghazagh
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  2. Masoud Frounchi
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Correspondence to Masoud Frounchi.

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Ghazagh, P., Frounchi, M. Hydroxyapatite/alginate/polyvinyl alcohol/agar composite double-network hydrogels as injectable drug delivery microspheres. Chem. Pap. 78, 2967–2976 (2024). https://doi.org/10.1007/s11696-023-03285-2

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